UMEMOTO TERUMASA

Profile Information

Affiliation: International Research Center for Medical Sciences, Kumamoto University

Degree: 博士（理学）

J-GLOBAL ID: 201601014140844424
researchmap Member ID: 7000016884

Research Areas

Papers

MITOL deficiency triggers hematopoietic stem cell apoptosis via ER stress response

Wenjuan Ma, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Ahad Khalilnezhad, Miho Kataoka, Yuichiro Arima, Yosuke Tanaka, Shigeru Yanagi, Terumasa Umemoto, Toshio Suda

The EMBO Journal, 43(3) 339-361, Jan 18, 2024 Peer-reviewedCorresponding author
Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice.

Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi Miharada, Yosuke Tanaka, Toshio Suda

Experimental hematology, Oct 26, 2023
Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion

Xichen Hu, Tadahito Yasuda, Noriko Yasuda-Yosihara, Atsuko Yonemura, Terumasa Umemoto, Yutaka Nakachi, Kohei Yamashita, Takashi Semba, Kota Arima, Tomoyuki Uchihara …

JHEP Reports, 100892-100892, Aug, 2023
Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.

Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy J Y Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi …

Cancer research, 83(5) 753-770, Dec 21, 2022
Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells

Yuji Takihara, Takumi Higaki, Tomomasa Yokomizo, Terumasa Umemoto, Kazunori Ariyoshi, Michihiro Hashimoto, Maiko Sezaki, Hitoshi Takizawa, Toshihiro Inoue, Toshio Suda …

Communications Biology, 5(1), Dec, 2022 Peer-reviewed
Tsukushi proteoglycan maintains RNA splicing and developmental signaling network in GFAP-expressing subventricular zone neural stem/progenitor cells

Arif Istiaq, Terumasa Umemoto, Naofumi Ito, Toshio Suda, Kenji Shimamura, Kunimasa Ohta

Frontiers in Cell and Developmental Biology, 10, Nov 21, 2022
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.

Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida …

The EMBO journal, 41(8) e109463, Mar 1, 2022 Peer-reviewedLead authorCorresponding author
Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.

Lingfeng Fu, Atsuko Yonemura, Noriko Yasuda-Yoshihara, Terumasa Umemoto, Jun Zhang, Tadahito Yasuda, Tomoyuki Uchihara, Takahiko Akiyama, Fumimasa Kitamura, Kohei Yamashita …

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 25(3) 542-557, Feb 15, 2022 Peer-reviewed
Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.

Yosuke Tanaka, Reina Takeda, Tsuyoshi Fukushima, Keiko Mikami, Shun Tsuchiya, Moe Tamura, Keito Adachi, Terumasa Umemoto, Shuhei Asada, Naoki Watanabe …

Nature communications, 13(1) 271-271, Jan 12, 2022 Peer-reviewed
Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates.

Michihiro Hashimoto, Terumasa Umemoto, Ayako Nakamura-Ishizu, Takayoshi Matsumura, Tomomasa Yokomizo, Maiko Sezaki, Hitoshi Takizawa, Toshio Suda

Blood advances, 5(6) 1594-1604, Mar 23, 2021 Peer-reviewedLead author
Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.

Yuichiro Arima, Yoshiko Nakagawa, Toru Takeo, Toshifumi Ishida, Toshihiro Yamada, Shinjiro Hino, Mitsuyoshi Nakao, Sanshiro Hanada, Terumasa Umemoto, Toshio Suda …

Nature metabolism, 3(2) 196-210, Feb, 2021 Peer-reviewed
A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity

Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang …

Cell Reports, 30(6) 1823-1834, Feb 11, 2020 Peer-reviewed
Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation.

Maiko Sezaki, Yoshikazu Hayashi, Yuxin Wang, Alban Johansson, Terumasa Umemoto, Hitoshi Takizawa

Frontiers in immunology, 11 585367-585367, 2020 Peer-reviewed
Discrimination of Dormant and Active Hematopoietic Stem Cells by G0 Marker Reveals Dormancy Regulation by Cytoplasmic Calcium

Tsuyoshi Fukushima, Yosuke Tanaka, Fiona K. Hamey, Chih-Hsiang Chang, Toshihiko Oki, Shuhei Asada, Yasutaka Hayashi, Takeshi Fujino, Taishi Yonezawa, Reina Takeda …

Cell Reports, 29(12) 4144-4158.e7, Dec, 2019 Peer-reviewed
High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.

Yuji Takihara, Ayako Nakamura-Ishizu, Darren Qiancheng Tan, Masahiro Fukuda, Takayoshi Matsumura, Mitsuhiro Endoh, Yuichiro Arima, Desmond Wai Loon Chin, Terumasa Umemoto, Michihiro Hashimoto …

Blood advances, 3(15) 2323-2327, Aug 13, 2019 Peer-reviewed
Hlf marks the developmental pathway for hematopoietic stem cells but not for erythro-myeloid progenitors

Tomomasa Yokomizo, Naoki Watanabe, Terumasa Umemoto, Junichi Matsuo, Ryota Harai, Yoshihiko Kihara, Eri Nakamura, Norihiro Tada, Tomohiko Sato, Tomoiku Takaku …

Journal of Experimental Medicine, 216(7) 1599-1614, Jul 1, 2019 Peer-reviewed
Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation

Ayako Nakamura-Ishizu, Takayoshi Matsumura, Patrick S. Stumpf, Terumasa Umemoto, Hitoshi Takizawa, Yuji Takihara, Aled O'Neil, A'Qilah Banu Bte Abdul Majeed, Ben D. MacArthur, Toshio Suda

Cell Reports, 25(7) 1772-1785.e6, Nov, 2018 Peer-reviewed
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation.

Masaya Baba, Mitsuhiro Endoh, Wenjuan Ma, Hirofumi Toyama, Akiyoshi Hirayama, Keizo Nishikawa, Keiyo Takubo, Hiroyuki Hano, Hisashi Hasumi, Terumasa Umemoto …

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 33(10) 1785-1798, Oct, 2018 Peer-reviewed
Ca²⁺-mitochondria axis drives cell division in hematopoietic stem cells.

Umemoto T, Hashimoto M, Matsumura T, Nakamura-Ishizu A, Suda T

The Journal of experimental medicine, 215(8) 2097-2113, Aug, 2018 Peer-reviewedLead authorCorresponding author
Ribosome Incorporation into Somatic Cells Promotes Lineage Transdifferentiation towards Multipotency

Naofumi Ito, Kaoru Katoh, Hiroko Kushige, Yutaka Saito, Terumasa Umemoto, Yu Matsuzaki, Hiroshi Kiyonari, Daiki Kobayashi, Minami Soga, Takumi Era …

SCIENTIFIC REPORTS, 8(1) 1634-1634, Jan, 2018 Peer-reviewed

Misc.

マウス胎生期における造血幹細胞の成熟はEvi-1/Hlf軸によって制御される(Evi-1/Hlf axis regulates HSC maturation in the mouse embryo)

横溝智雅, 渡邊直紀, 梅本晃正, 高久智生, 須田年生, 黒川峰夫, 小松則夫, 大里元美

臨床血液, 59(9) 1571-1571, Sep, 2018
RAPID AND DIRECT MEGAKARYOCYTE-LINEAGE DIFFERENTIATION FROM HSCS HALLMARK HEMATOPOIETIC SYSTEM RESPONSE TO STRESS

Ayako Nakamura-Ishizu, Takayoshi Matsumura, Terumasa Umemoto, A'Qilah Abdul Majeed, Toshio Suda

EXPERIMENTAL HEMATOLOGY, 44(9) S91-S91, Sep, 2016
Functional analysis of the transcription factors specifically expressed in hematopoietic stem cells

S. Kozakai, T. Umemoto, M. Yamato, M. Umezu, T. Okano

MOLECULAR BIOLOGY OF THE CELL, 25, Dec, 2014
EGFL7は骨髄中の微小環境における造血幹/前駆細胞の運命をβ3インテグリンを介して制御する(EGFL7 regulates hematopoietic stem/progenitor cell fate in the bone marrow niche through β3 integrin)

Salama Yousef, Nishida Chiemi, Gritli Ismael, Umemoto Terumasa, Nakauchi Hiromitsu, Hattori Koichi, Heissig Beate

臨床血液, 55(9) 1352-1352, Sep, 2014
Lgr5 mediated integrin signaling promotes the proliferation of dental epithelial progenitor cells

T. Yoshida, T. Iwata, T. Umemoto, Y. Shiratsuchi, N. Kawashima, T. Sugiyama, M. Yamato, T. Okano

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6 11-11, Sep, 2012
Nov/CCN3 Enhances Long-Term Repopulating Activity of Mouse Hematopoietic Stem Cells Via Intergin beta 3 Signaling Collaborating with Thrombopoietin

Jun Ishihara, Terumasa Umemoto, Masayuki Yamato, Yoshiko Shiratsuchi, Brian G. Petrich, Hiromitsu Nakauchi, Koji Eto, Toshio Kitamura, Teruo Okano

BLOOD, 118(21) 393-394, Nov, 2011
CD61 Integrin beta 3 Ligation Contributes to the Thrombopoietin-Mediated Niche Function of Mouse Hematopoietic Stem Cells

Terumasa Umemoto, Masayuki Yamato, Yoshiko Shiratsuchi, Kenji Tsukada, Mika Utsumi, Yohei Morita, Masato Terasawa, Takehiko Shibata, Kohji Nishida, Yoshiro Kobayashi …

BLOOD, 114(22) 160-160, Nov, 2009
Human limbal epithelium contains side population cells defined by expression of the ATP-binding cassette transporter ABCG2

K Watanabe, K Nishida, M Yamato, T Umemoto, T Sumide, K Yamamoto, T Okano, Y Tano

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 45 U124-U124, Apr, 2004

Research Projects

「硬さ」を計測し操作する造血幹細胞の増殖・分化制御系

科学研究費助成事業, 挑戦的研究(開拓), 日本学術振興会, Jun, 2023 - Mar, 2026

山田真澄, 三原田賢一, 梅本晃正
生体イメージングと網羅的解析によるミトコンドリア面からみた緑内障とその治療法探索

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

瀧原祐史, 井上俊洋, 梅本晃正, 有馬勇一郎, 水野秀信
クロマチン動態の差異に起因する造血幹細胞のサイトカイン応答パラドックス

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2023 - Mar, 2026

梅本晃正, 田中洋介
造血幹細胞のサイトカイン応答を規定するクロマチン動態変化の制御

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

梅本晃正
Self-renewal capacity of hematopoietic stem cells and mitochondrial metabolism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2023
Angiogenic machinery via concerted biomechanical control by blood flow pericyte

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Nishiyama Koichi
Energy metabolism-dependent selection of self-renewal and differnetiation in HSCs

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Umemoto Terumasa
The maintenance of hematopoietic stem cells through tuning TPO response

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2021

Umemoto Terumasa
IFNgamma-mediated regulation of hematopoeitc stem cells in stress hematopoiesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2019

Umemoto Terumasa
Homeostasis of hematopoietic stem cells and its breakdown

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2014 - Mar, 2019

SUDA Toshio
AlphaVbeta3 integrin bidirectionally regulates hematopoietic stem cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Umemoto Terumasa

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Research Areas

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Misc.

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