松﨑泰教 (Yasunori Matsuzaki) - マイポータル

基本情報

所属: 群馬大学大学院医学系研究科脳神経再生医学分野助教 (研究科講師)

J-GLOBAL ID: 201701013763729619
researchmap会員ID: 7000020296

外部リンク: http://synapse.dept.med.gunma-u.ac.jp/

【学歴】
2008年3月近畿大学生物理工学部遺伝子工学科卒業
2010年3月信州大学大学院医学系研究科医科学専攻修了
2014年3月群馬大学大学院医学系研究科医科学専攻修了
【職歴】
2014年4月群馬大学大学院医学系研究科脳神経再生医学分野研究員
2015年4月群馬大学大学院医学系研究科脳神経再生医学分野産学官連携研究員
2015年7月群馬大学大学院医学系研究科脳神経再生医学分野助教
2018年4月群馬大学大学院医学系研究科脳神経再生医学分野助教兼研究科講師

研究キーワード

研究分野

論文

A blood-brain barrier-penetrating AAV2 mutant created by a brain microvasculature endothelial cell-targeted AAV2 variant.

Hayato Kawabata, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai

Molecular therapy. Methods & clinical development 29 81-92 2023年6月8日
Protein kinase Cγ in cerebellar Purkinje cells regulates Ca2+-activated large-conductance K+ channels and motor coordination

Masashi Watanave, Nobutaka Takahashi, Nobutake Hosoi, Ayumu Konno, Hikaru Yamamoto, Hiroyuki Yasui, Mika Kawachi, Takuro Horii, Yasunori Matsuzaki, Izuho Hatada, Hirokazu Hirai

Proceedings of the National Academy of Sciences 119(7) e2113336119-e2113336119 2022年2月15日査読有り
Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB

Putri T. Radhiyanti, Ayumu Konno, Yasunori Matsuzaki, Hirokazu Hirai

Neuroscience Letters 756 135956-135956 2021年6月査読有り
Global Knockdown of Retinoid-related Orphan Receptor α in Mature Purkinje Cells Reveals Aberrant Cerebellar Phenotypes of Spinocerebellar Ataxia.

Hiroyuki Yasui, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai

Neuroscience 462 328-336 2020年4月8日査読有り
Neurotropic Properties of AAV-PHP.B Are Shared among Diverse Inbred Strains of Mice.

Matsuzaki Y,Tanaka M,Hakoda S,Masuda T,Miyata R,Konno A,Hirai H

Molecular therapy : the journal of the American Society of Gene Therapy 2019年2月査読有り
Pharmacological enhancement of retinoid-related orphan receptor α function mitigates spinocerebellar ataxia type 3 pathology.

Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H

Neurobiology of disease 121 263-273 2019年1月査読有り
Effects of Neutralizing Antibody Production on AAV-PHP.B-Mediated Transduction of the Mouse Central Nervous System.

Shinohara Y,Konno A,Nitta K,Matsuzaki Y,Yasui H,Suwa J,Hiromura K,Hirai H

Molecular neurobiology 2018年10月査読有り
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain

Yasunori Matsuzaki, Ayumu Konno, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada, Hirokazu Hirai

Neuroscience Letters 665 182-188 2018年2月5日査読有り
Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning.

Masashi Watanave, Yasunori Matsuzaki, Yasuyo Nakajima, Atsushi Ozawa, Masanobu Yamada, Hirokazu Hirai

Frontiers in cellular neuroscience 12 490-490 2018年査読有り
Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells

Nobutaka Takahashi, Anton N. Shuvaev, Ayumu Konno, Yasunori Matsuzaki, Masashi Watanave, Hirokazu Hirai

JOURNAL OF NEUROCHEMISTRY 143(6) 660-670 2017年12月査読有り
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates

Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 6 159-170 2017年9月査読有り
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors

Yasunori Matsuzaki, Ayumu Konno, Ryo Mukai, Fumiaki Honda, Masafumi Hirato, Yuhei Yoshimoto, Hirokazu Hirai

MOLECULAR NEUROBIOLOGY 54(3) 1745-1758 2017年4月査読有り
Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice

Fathul Huda, Yiping Fan, Mamiko Suzuki, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry K. Y. Chan, Hirokazu Hirai

PLOS ONE 11(11) e0164202 2016年11月査読有り
Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

Yoichiro Shinohara, Ayumu Konno, Nobutaka Takahashi, Yasunori Matsuzaki, Shoji Kishi, Hirokazu Hirai

PLOS ONE 11(8) e0162023 2016年8月査読有り
Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous RORα.

Iizuka A, Matsuzaki Y, Konno A, Hirai H

Brain structure & function 221(6) 2879-2889 2016年7月査読有り
Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice

Shinya Kusakari, Fumihito Saitow, Yukio Ago, Koji Shibasaki, Miho Sato-Hashimoto, Yasunori Matsuzaki, Takenori Kotani, Yoji Murata, Hirokazu Hirai, Toshio Matsuda, Hidenori Suzuki, Takashi Matozaki, Hiroshi Ohnishi

MOLECULAR AND CELLULAR BIOLOGY 35(9) 1557-1572 2015年5月査読有り
Generation of a neurodegenerative disease mouse model using lentiviral vectors carrying an enhanced synapsin I promoter

Yasunori Matsuzaki, Miho Oue, Hirokazu Hirai

JOURNAL OF NEUROSCIENCE METHODS 223 133-143 2014年2月査読有り
Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

Fathul Huda, Ayumu Konno, Yasunori Matsuzaki, Hanna Goenawan, Koichi Miyake, Takashi Shimada, Hirokazu Hirai

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 1 14032 2014年査読有り
Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

Tomohiko Irie, Yasunori Matsuzaki, Yuko Sekino, Hirokazu Hirai

JOURNAL OF PHYSIOLOGY-LONDON 592(1) 229-247 2014年1月査読有り
The Murine Stem Cell Virus Promoter Drives Correlated Transgene Expression in the Leukocytes and Cerebellar Purkinje Cells of Transgenic Mice

Miho Oue, Hiroshi Handa, Yasunori Matsuzaki, Kazutomo Suzue, Hirokazu Murakami, Hirokazu Hirai

PLOS ONE 7(11) e51015 2012年11月査読有り

もっとみる

MISC

Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain

Yasunori Matsuzaki, Ayumu Konno, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada, Hirokazu Hirai

Neuroscience Letters 665 182-188 2018年2月5日
Intravenous administration of the adeno-associated virus-PHP.B capsid fails to upregulate transduction efficiency in the marmoset brain

Yasunori Matsuzaki, Ayumu Konno, Ryuta Mochizuki, Yoichiro Shinohara, Keisuke Nitta, Yukihiro Okada, Hirokazu Hirai

Neuroscience Letters 665 182-188 2018年2月5日
リピート病における神経変性の分子機構解明を目指してアデノ随伴ウイルスによる遺伝子導入を介したリピート病モデル動物の作出と治療法の開発

今野歩, 渡邊将, 星野千秋, 篠原洋一郎, 松崎泰教, 平井宏和

生命科学系学会合同年次大会 2017年度 [3PW23-3] 2017年12月
Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells

Nobutaka Takahashi, Anton N. Shuvaev, Ayumu Konno, Yasunori Matsuzaki, Masashi Watanave, Hirokazu Hirai

JOURNAL OF NEUROCHEMISTRY 143(6) 660-670 2017年12月
Regulatory connection between the expression level of classical protein kinase C and pruning of climbing fibers from cerebellar Purkinje cells

Nobutaka Takahashi, Anton N. Shuvaev, Ayumu Konno, Yasunori Matsuzaki, Masashi Watanave, Hirokazu Hirai

JOURNAL OF NEUROCHEMISTRY 143(6) 660-670 2017年12月
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates

Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai

Molecular Therapy - Methods and Clinical Development 6 159-170 2017年9月15日
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates

Keisuke Nitta, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 6 159-170 2017年9月
Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors

Yasunori Matsuzaki, Ayumu Konno, Ryo Mukai, Fumiaki Honda, Masafumi Hirato, Yuhei Yoshimoto, Hirokazu Hirai

MOLECULAR NEUROBIOLOGY 54(3) 1745-1758 2017年4月
Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice

Fathul Huda, Yiping Fan, Mamiko Suzuki, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry K. Y. Chan, Hirokazu Hirai

PLOS ONE 11(11) e0164202 2016年11月
Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice

Fathul Huda, Yiping Fan, Mamiko Suzuki, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry K. Y. Chan, Hirokazu Hirai

PLOS ONE 11(11) e0164202 2016年11月
Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

Yoichiro Shinohara, Ayumu Konno, Nobutaka Takahashi, Yasunori Matsuzaki, Shoji Kishi, Hirokazu Hirai

PLOS ONE 11(8) e0162023 2016年8月
Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains

Yoichiro Shinohara, Ayumu Konno, Nobutaka Takahashi, Yasunori Matsuzaki, Shoji Kishi, Hirokazu Hirai

PLOS ONE 11(8) e0162023 2016年8月
Plasticity of the developmentally arrested staggerer cerebellum in response to exogenous ROR alpha

Akira Iizuka, Yasunori Matsuzaki, Ayumu Konno, Hirokazu Hirai

BRAIN STRUCTURE & FUNCTION 221(6) 2879-2889 2016年7月
Fusion of Mesenchymal Stem Cells Exclusively with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice

Fathul Huda, Yiping Fan, Ayumu Konno, Yasunori Matsuzaki, Nobutaka Takahashi, Jerry Chan, Hirokazu Hirai

MOLECULAR THERAPY 23 S237-S237 2015年5月
Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice

Shinya Kusakari, Fumihito Saitow, Yukio Ago, Koji Shibasaki, Miho Sato-Hashimoto, Yasunori Matsuzaki, Takenori Kotani, Yoji Murata, Hirokazu Hirai, Toshio Matsuda, Hidenori Suzuki, Takashi Matozaki, Hiroshi Ohnishi

MOLECULAR AND CELLULAR BIOLOGY 35(9) 1557-1572 2015年5月
Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice

Shinya Kusakari, Fumihito Saitow, Yukio Ago, Koji Shibasaki, Miho Sato-Hashimoto, Yasunori Matsuzaki, Takenori Kotani, Yoji Murata, Hirokazu Hirai, Toshio Matsuda, Hidenori Suzuki, Takashi Matozaki, Hiroshi Ohnishi

MOLECULAR AND CELLULAR BIOLOGY 35(9) 1557-1572 2015年5月
One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice

H. Saida, Y. Matsuzaki, K. Takayama, A. Iizuka, A. Konno, S. Yanagi, H. Hirai

GENE THERAPY 21(9) 820-827 2014年9月
One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice

H. Saida, Y. Matsuzaki, K. Takayama, A. Iizuka, A. Konno, S. Yanagi, H. Hirai

GENE THERAPY 21(9) 820-827 2014年9月
Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

Fathul Huda, Ayumu Konno, Yasunori Matsuzaki, Hanna Goenawan, Koichi Miyake, Takashi Shimada, Hirokazu Hirai

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT 1 UNSP 14032 2014年
Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells

Tomohiko Irie, Yasunori Matsuzaki, Yuko Sekino, Hirokazu Hirai

JOURNAL OF PHYSIOLOGY-LONDON 592(1) 229-247 2014年1月

もっとみる

講演・口頭発表等

AAV9ベクターを用いたマーモセット中枢神経系への効率的な遺伝子導入法

松﨑泰教

第5回日本マーモセット研究会大会 2016年1月17日

主要な所属学協会

共同研究・競争的資金等の研究課題

超効率血管脳移行AAVベクターによるマーモセットでのin vivoノックアウト

日本学術振興会若手研究(B) 2017年4月 - 2019年3月

松﨑泰教
脊髄小脳変性症モデルとなるコモンマーモセットの作出および薬物治療の評価

日本学術振興会研究活動スタート支援 2014年8月 - 2015年3月

松﨑泰教
脊髄小脳変性症モデルマーモセットの運動失調評価システムの構築

自然科学研究機構新分野創成センターブレインサイエンス研究分野プロジェクト 2014年7月 - 2015年3月

松﨑泰教

松﨑泰教