2015年9月
Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz
JOURNAL OF GENERAL VIROLOGY
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- 巻
- 96
- 号
- 開始ページ
- 2867
- 終了ページ
- 2877
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1099/vir.0.000207
- 出版者・発行元
- SOC GENERAL MICROBIOLOGY
It has been estimated that human immunodeficiency virus type 1 originated from the zoonotic transmission of simian immunodeficiency virus (SIV) of chimpanzees, SIVcpz, and that SIVcpz emerged by the recombination of two lineages of SIVs in Old World monkeys (SIVgsn/mon/mus in guenons and SIVrcm in red-capped mangabeys) and SIVcpz Nef is most closely related to SIVrcnn Nef. These observations suggest that SIVrcm Nef had an advantage over SIVgsn/nnon/mus during the evolution of SIVcpz in chimpanzees, although this advantage remains uncertain. Nef is a multifunctional protein which downregulates CD4 and coreceptor proteins from the surface of infected cells, presumably to limit superinfection. To assess the possibility that SIVrcm Net was selected by its superior ability to downregulate viral entry receptors in chimpanzees, we compared its ability to down-modulate viral receptor proteins from humans, chimpanzees and red-capped mangabeys with Net proteins from eight other different strains of SIVs. Surprisingly, the ability of SIVrcm Net to downregulate CCR5, CCR2B and CXCR6 was comparable to or lower than SIVgsn/mon/mus Net, indicating that ability to down-modulate chennokine receptors was not the selective pressure. However, SIVrcm Nef significantly downregulates chimpanzee CD4 over SIVgsn/mon/mus Nets. Our findings suggest the possibility that the selection of SIVrcm Nef by ancestral SIVcpz is due to its superior capacity to down-modulate chimpanzees CD4 rather than coreceptor proteins.
- リンク情報
- ID情報
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- DOI : 10.1099/vir.0.000207
- ISSN : 0022-1317
- eISSN : 1465-2099
- Web of Science ID : WOS:000363915400040