論文

査読有り
2015年9月

Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz

JOURNAL OF GENERAL VIROLOGY
  • Yusuke Nakano
  • ,
  • Kenta Matsuda
  • ,
  • Rokusuke Yoshikawa
  • ,
  • Eri Yamada
  • ,
  • Naoko Misawa
  • ,
  • Vanessa M. Hirsch
  • ,
  • Yoshio Koyanagi
  • ,
  • Kei Sato

96
開始ページ
2867
終了ページ
2877
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1099/vir.0.000207
出版者・発行元
SOC GENERAL MICROBIOLOGY

It has been estimated that human immunodeficiency virus type 1 originated from the zoonotic transmission of simian immunodeficiency virus (SIV) of chimpanzees, SIVcpz, and that SIVcpz emerged by the recombination of two lineages of SIVs in Old World monkeys (SIVgsn/mon/mus in guenons and SIVrcm in red-capped mangabeys) and SIVcpz Nef is most closely related to SIVrcnn Nef. These observations suggest that SIVrcm Nef had an advantage over SIVgsn/nnon/mus during the evolution of SIVcpz in chimpanzees, although this advantage remains uncertain. Nef is a multifunctional protein which downregulates CD4 and coreceptor proteins from the surface of infected cells, presumably to limit superinfection. To assess the possibility that SIVrcm Net was selected by its superior ability to downregulate viral entry receptors in chimpanzees, we compared its ability to down-modulate viral receptor proteins from humans, chimpanzees and red-capped mangabeys with Net proteins from eight other different strains of SIVs. Surprisingly, the ability of SIVrcm Net to downregulate CCR5, CCR2B and CXCR6 was comparable to or lower than SIVgsn/mon/mus Net, indicating that ability to down-modulate chennokine receptors was not the selective pressure. However, SIVrcm Nef significantly downregulates chimpanzee CD4 over SIVgsn/mon/mus Nets. Our findings suggest the possibility that the selection of SIVrcm Nef by ancestral SIVcpz is due to its superior capacity to down-modulate chimpanzees CD4 rather than coreceptor proteins.

リンク情報
DOI
https://doi.org/10.1099/vir.0.000207
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000363915400040&DestApp=WOS_CPL
ID情報
  • DOI : 10.1099/vir.0.000207
  • ISSN : 0022-1317
  • eISSN : 1465-2099
  • Web of Science ID : WOS:000363915400040

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