2004年6月
Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-alpha
JOURNAL OF NEUROIMMUNOLOGY
- 巻
- 151
- 号
- 1-2
- 開始ページ
- 189
- 終了ページ
- 194
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuroim.2004.02.007
- 出版者・発行元
- ELSEVIER SCIENCE BV
We studied the immunological and virological effects of interferon-a (IFN-alpha) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-gamma+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type I (Th1)-related responses tended to be higher and reduce more evidently following therapy in three patients who clinically improved. Also, all the three patients had one or more HTLV-I copies in five blood mononuclear cells. These results suggest that IFN-alpha suppresses Th1 responses in HAM/TSP and that the patients with higher Th1 immunity and proviral loads may be responders of the therapy. Larger-scale studies are needed to confirm the findings. (C) 2004 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuroim.2004.02.007
- ISSN : 0165-5728
- Web of Science ID : WOS:000221895000020