2012年
Identifying viral parameters from in vitro cell cultures
FRONTIERS IN MICROBIOLOGY
- ,
- ,
- ,
- ,
- ,
- 巻
- 3
- 号
- SEP
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3389/fmicb.2012.00319
- 出版者・発行元
- FRONTIERS RESEARCH FOUNDATION
Current in vitro cell culture studies of viral replication deliver detailed time courses of several virological variables, like the amount of virions and the number of target cells, measured over several days of the experiment. Each of these time points solely provides a snap shot of the virus infection kinetics and is brought about by the complex interplay of target cell infection, and viral production and cell death. It remains a challenge to interpret these data quantitatively and to reveal the kinetics of these underlying processes to understand how the viral infection depends on these kinetic properties. In order to decompose the kinetics of virus infection, we introduce a method to "quantitatively" describe the virus infection in in vitro cell cultures, and discuss the potential of the mathematical based analyses for experimental virology.
- リンク情報
- ID情報
-
- DOI : 10.3389/fmicb.2012.00319
- ISSN : 1664-302X
- Web of Science ID : WOS:000208863600324