2003年11月
Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA
JOURNAL OF BIOCHEMISTRY
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- 巻
- 134
- 号
- 5
- 開始ページ
- 637
- 終了ページ
- 639
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/jh/mvg200
- 出版者・発行元
- JAPANESE BIOCHEMICAL SOC
The nucleocapsid protein of HIV-1 consists of two basic amino acid regions and two zinc fingers. We investigated the requirement of these domains for the structural conversion of a 39mer RNA covering the dimerization initiation site by using three peptides; wild-type NCp7, a mutant in which the two zinc fingers are mutated, and another mutant in which the two zinc fingers are deleted. The two mutants exhibited similar conversion activities to each other, which were lower than that of the wildtype, indicating that the two basic regions exhibit some activity for RNA chaperone, as we suggested before, and the zinc fingers enhance the efficiency of this activity.
- リンク情報
- ID情報
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- DOI : 10.1093/jh/mvg200
- ISSN : 0021-924X
- CiNii Articles ID : 10012058794
- Web of Science ID : WOS:000187492900003