Yasushi Kawaguchi - My portal

Profile Information

Affiliation: 教授, 医科学研究所, 東京大学

J-GLOBAL ID: 201901018766047450
researchmap Member ID: B000359567

Research Areas

Life sciences / Virology /

Major Papers

239

Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

Akihisa Kato, Shungo Adachi, Shuichi Kawano, Kousuke Takeshima, Mizuki Watanabe, Shinobu Kitazume, Ryota Sato, Hideo Kusano, Naoto Koyanagi, Yuhei Maruzuru …

Nature communications, 11(1) 4894-4894, Sep 29, 2020 Peer-reviewed
Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

Ryota Sato, Akihisa Kato, Takahiko Chimura, Shin Ichiroh Saitoh, Takuma Shibata, Yusuke Murakami, Ryutaro Fukui, Kaiwen Liu, Yun Zhang, Jun Arii …

Nature Immunology, 19(10) 1071-1082, Oct 1, 2018 Peer-reviewedCorresponding author
ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity.

Jun Arii, Mizuki Watanabe, Fumio Maeda, Noriko Tokai-Nishizumi, Takahiro Chihara, Masayuki Miura, Yuhei Maruzuru, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi

Nature communications, 9(1) 3379-3379, Aug 23, 2018 Peer-reviewed
Herpes Simplex Virus 1 VP22 Inhibits AIM2-Dependent Inflammasome Activation to Enable Efficient Viral Replication

Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe …

Cell Host and Microbe, 23(2) 254-265.e7, Feb 14, 2018 Peer-reviewed
Herpes simplex virus-1 evasion of CD8⁺ T cell accumulation contributes to viral encephalitis

Naoto Koyanagi, Takahiko Imai, Keiko Shindo, Ayuko Sato, Wataru Fujii, Takeshi Ichinohe, Naoki Takemura, Shigeru Kakuta, Satoshi Uematsu, Hiroshi Kiyono …

Journal of Clinical Investigation, 127(10) 3784-3795, Oct 2, 2017 Peer-reviewed
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1

Jun Arii, Hideo Goto, Tadahiro Suenaga, Masaaki Oyama, Hiroko Kozuka-Hata, Takahiko Imai, Atsuko Minowa, Hiroomi Akashi, Hisashi Arase, Yoshihiro Kawaoka …

Nature, 467(7317) 859-862, Oct 14, 2010 Peer-reviewed
Simultaneous tracking of capsid, tegument, and envelope protein localization in living cells infected with triply fluorescent herpes simplex virus 1

Ken Sugimoto, Masashi Uema, Hiroshi Sagara, Michiko Tanaka, Tetsutaro Sata, Yasuhiro Hashimoto, Yasushi Kawaguchi

Journal of Virology, 82(11) 5198-5211, Jun, 2008 Peer-reviewed
PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

Takeshi Satoh, Jun Arii, Tadahiro Suenaga, Jing Wang, Amane Kogure, Junji Uehori, Noriko Arase, Ikuo Shiratori, Shinya Tanaka, Yasushi Kawaguchi …

Cell, 132(6) 935-944, Mar 21, 2008 Peer-reviewed
Conserved protein kinases encoded by herpesviruses and cellular protein kinase cdc2 target the same phosphorylation site in eukaryotic elongation factor 1δ

Yasushi Kawaguchi, Kentaro Kato, Michiko Tanaka, Mikiko Kanamori, Yukihiro Nishiyama, Yuji Yamanashi

Journal of Virology, 77(4) 2359-2368, Feb, 2003 Peer-reviewed
Construction of an excisable bacterial artificial chromosome containing a full-length infectious clone of herpes simplex virus type 1: Viruses reconstituted from the clone exhibit wild-type properties in vitro and in vivo

Michiko Tanaka, Hiroyuki Kagawa, Yuji Yamanashi, Tetsutaro Sata, Yasushi Kawaguchi

Journal of Virology, 77(2) 1382-1391, Jan, 2003 Peer-reviewed
Herpes simplex virus 1 α regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1

Yasushi Kawaguchi, Michiko Tanaka, Akihiko Yokoymama, Go Matsuda, Kentaro Kato, Hiroyuki Kagawa, Kanji Hirai, Bernard Roizman

Proceedings of the National Academy of Sciences of the United States of America, 98(4) 1877-1882, Feb 13, 2001 Peer-reviewed
A single amino acid substitution in the cyclin D binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate

C. Van Sant, Y. Kawaguchi, B. Roizman

Proceedings of the National Academy of Sciences of the United States of America, 96(14) 8184-8189, Jul 6, 1999 Peer-reviewed
Eukaryotic elongation factor 1δ is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1

Yasushi Kawaguchi, Charles Van Sant, Bernard Roizman

Journal of Virology, 72(3) 1731-1736, Mar, 1998 Peer-reviewed
Interaction of herpes simplex virus 1 α regulatory protein ICP0 with elongation factor 1δ: ICP0 affects translational machinery

Yasushi Kawaguchi, Renato Bruni, Bernard Roizman

Journal of Virology, 71(2) 1019-1024, Feb, 1997 Peer-reviewed
Herpes simplex virus 1 α regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3

Yasushi Kawaguchi, Charles Van Sant, Bernard Roizman

Journal of Virology, 71(10) 7328-7336, 1997 Peer-reviewed

Awards

Major Research History

2011 - Present

教授, 医科学研究所感染・免疫部門ウイルス病態制御分野, 東京大学
2005 - 2011

准教授 (分野長), 医科学研究所感染症国際研究センターウイルス学分野, 東京大学
2002 - 2005

助教授, 医学部, 名古屋大学
1997 - 2002

助手、講師 (1999~)、助教授 (2000~), 難治疾患研究所, 東京医科歯科大学
1995 - 1997

博士研究員, シカゴ大学

Education

Misc.

単純ヘルペスウイルス1型がコードするUs3リン酸化酵素の基質特異性に関する制御機構

加藤哲久, 木村南美, 小柳直人, 丸鶴雄平, 有井潤, 五十嵐学, 川口寧

日本ウイルス学会学術集会プログラム・予稿集(Web), 67th, 2019
Combating herpesvirus encephalitis by potentiating a TLR3-mTORC2 axis

SATO Ryota, KATO Akihisa, CHIMURA Takahiko, SAITOH Shin-Ichiroh, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, LIU Kaiwen, ZHANG Yun, MANABE Toshiya …

日本免疫学会総会・学術集会記録(CD-ROM), 47, 2018
The cutting edge of the mechanism in herpesvirus replication and pathogenesis

260(6) 504-508, Feb 11, 2017
Fatty acid synthesis pathway is required for TLR3 response through mTORC2 activity

SATO Ryota, SAITOH Shin-ichiroh, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, KATO Akihisa, ARII Jun, KAWAGUCHI Yasushi, MIYAKE Kensuke

日本免疫学会総会・学術集会記録, 45(Proceedings), 2016
TLR3応答におけるmTORの機能解析

SATO Ryota, SAITOH Shin’ichiro, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, KATO Akihisa, ARII Jun, KAWAGUCHI Yasushi, MIYAKE Kensuke

日本分子生物学会年会プログラム・要旨集(Web), 39th, 2016
The role of mTOR in TLR3 responses to Herpes Simplex Virus infection

SATO Ryota, SAITOH Shin-ichiroh, SHIBATA Takuma, FUKUI Ryutaro, MURAKAMI Yusuke, KATO Akihisa, ARII Jun, KAWAGUCHI Yasushi, MIYAKE Kensuke

日本免疫学会総会・学術集会記録, 44(Proceedings), 2015
Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli (vol 53, pg 393, 2014)

Katsutoshi Imamura, Naoto Imamachi, Gen Akizuki, Michiko Kumakura, Atsushi Kawaguchi, Kyosuke Nagata, Akihisa Kato, Yasushi Kawaguchi, Hiroki Sato, Misako Yoneda …

MOLECULAR CELL, 54(6) 1055-1055, Jun, 2014
HSV-2増殖に関わるPMLアイソフォーム発現制御

野島孝之, 野島孝之, 井手上(大城)社子, 仲野谷宗図, 川村豪伸, 森本智美, 川口寧, 片岡直行, 萩原正敏, 萩原正敏

生化学, 2009
ウイルスタンパク質のPML選択的スプライシング制御

野島孝之, 野島孝之, 井手上社子, 仲野谷宗図, 川村豪伸, 森本智美, 川口寧, 片岡直行, 萩原正敏, 萩原正敏

日本RNA学会年会要旨集, 11th, 2009
Crucial Role of O-Glycosylation on Glycoprotein B in Herpes Simplex Virus I Infection

Jing Wang, Takeshi Satoh, Jun Arii, Yasushi Kawaguchi, Patricia G. Spear, Hisashi Arase

GLYCOBIOLOGY, 18(11) 1000-1000, Nov, 2008
Regulation of immune response by HSV-1 via inhibitory PILR

Hisashi Arase, Yasushi Kawaguchi, Lewis L. Lanier, Takeshi Satoh

JOURNAL OF IMMUNOLOGY, 178, Apr, 2007
Pancreatic islet .BETA. cell injury by macrophage in a encephalomyocarditis virus infected mouse.

平沢健介, 前田健, 川口寧, 板垣慎一, 土井邦雄

日本獣医学会学術集会講演要旨集, 121st, 1996
チミジンキナーゼ遺伝子を欠損させた組み換え猫ヘルペスウイルス1型株の弱毒化

横山直明, 前田健, 遠矢幸伸, 川口寧, 辛ヨン実, 石黒信良, 佐川輝男, 磯貝礼二, 藤川勇治

日本獣医学会学術集会講演要旨集, 119th, 1995
糖蛋白gDはアルファヘルペスウイルスの宿主域規定因子の1つか?

前田健, 川口寧, 小野満, 横山直明, 藤田賢太郎, 見上彪

日本獣医学会学術集会講演要旨集, 120th, 1995
ネコヘルペスウイルス1型のヘパリン感受性

前田健, 平沢健介, 川口寧, 小野満, 横山直明, 遠矢幸伸, 見上彪

日本獣医学会学術集会講演要旨集, 119th, 1995
猫カリシウイルスに対する免疫原を発現する組換え猫ヘルペスウイルス1型

横山直明, 前田健, 遠矢幸伸, 川口寧, 猪島康雄, 藤田賢太郎, 見上彪

日本獣医学会学術集会講演要旨集, 120th, 1995
ネコヘルペスウイルス1型ICP4遺伝子の発現機構の解析

川口寧, 前田健, 小野満, 横山直明, 遠矢幸伸, 見上彪

日本獣医学会学術集会講演要旨集, 119th, 1995
ネコ免疫不全ウイルスネコFas cDNAのクローニング

坪田健次郎, 川口寧, PECORARO M, 小野満, 前田健, 見上彪

日本獣医学会学術集会講演要旨集, 118th, 1994
ネコカリシウイルスF4株の非構造蛋白遺伝子の塩基配列の決定

押鴨涼子, 遠矢幸伸, 朝長啓造, 川口寧, 前田健, 甲斐知恵子, 見上彪

日本獣医学会学術集会講演要旨集, 118th, 1994
狂犬病・カリシ・ハンタウイルス,PrP ネコカリシウイルスの中和エピトープマッピング

遠矢幸伸, 横山直明, 前田健, 川口寧, 辛れん実, 甲斐知恵子, 見上彪

日本獣医学会学術集会講演要旨集, 118th, 1994

Research Projects

Integrated molecular basis for herpesvirus replication and pathogenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, Aug, 2020 - Mar, 2025
ウイルスによる細胞内生命金属ハイジャック機構の解析

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2022 - Mar, 2024

川口寧
ウイルスキナーゼから紐解くリン酸化の新たな基質特異性制御システム

科学研究費助成事業, 挑戦的研究(萌芽), 日本学術振興会, Jul, 2021 - Mar, 2023

川口寧
「ネオウイルス学」の国際活動支援

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Jun, 2016 - Mar, 2023

河岡義裕, 朝長啓造, 澤洋文, 高橋英樹, 川口寧, 渡辺登喜子, 松浦善治, 鈴木信弘, 長崎慶三
ネオウイルス学：生命の源流から超個体、そしてエコ・スフィアーへ

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2021 - Mar, 2022

河岡義裕, 朝長啓造, 澤洋文, 松浦善治, 川口寧, 渡辺登喜子, 鈴木信弘, 高橋英樹, 長崎慶三
Comprehensive analysis of post-translational modification of herpesvirus based on big data analysis using supercomputer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022

KAWAGUCHI Yasushi
ヘルペスウイルスの増殖・病態発現に関する統合的分子基盤

科学研究費助成事業, 基盤研究(A), 日本学術振興会, Apr, 2020 - Mar, 2021

川口寧
Urgent research on COVID-19 utilizing infectious disease research stations in Asia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Special Purposes, Japan Society for the Promotion of Science, Feb, 2020 - Mar, 2021

MORITA Kouichi
Biological Significance of Latent Viral Infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2021

KAWAGUCHI Yasushi
Neo-virology: the raison d'etre of viruses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Jun, 2016 - Mar, 2021

Kawoaka Yoshihiro
Integrated in vivo analyses of neglected viral factors of herpes simplex virus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

Kawaguchi Yasushi
Comprehensive identification of host factors which contribute to replication of herpes virus using genome editing

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Kawaguchi Yasushi
Identification of receptor for cell-to-cell infection of HSV

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Arii Jun, KAWAGUCHI Yasushi, KATO Akihisa, KOYANAGI Naoto
Studies on entry and nuclear egress of Herpes Simplex Virus

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (A), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Arii Jun, KAWAGUCHI Yasushi, KATO Akihisa, KOYANAGI Naoto
Further analysis of phosphorylationin events in herpes simplex virus infection

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Akihisa Kato
Unifying functional analyses of multiple herpes simplex virus proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2018

Kawaguchi Yasushi
ウイルス感染における蛋白質の品質管理制御とそれに基づく広域阻害剤の薬効評価

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

川口寧
単純ヘルペスウイルスの小胞媒介性輸送の解析

科学研究費助成事業, 新学術領域研究(研究領域提案型), 日本学術振興会, Apr, 2015 - Mar, 2017

川口寧
Construction of novel platforms for herpes simplex virus attenuated vaccines

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kawaguchi Yasushi
単純ヘルペスウイルス因子の多面的機能解析

科学研究費助成事業, 基盤研究(B), 日本学術振興会, 2011 - 2011

川口寧