Prediction of river flow is very important for water resource management. Hydrologic models are one of the important tools to predict river discharge. The Ayeyarwady River is the longest and largest river in Myanmar with covering 60 % of the country’s territory. Most of people depend on this river for various reasons such as irrigation, transportation, hydroelectric power generation and others. So, to forecast the flow of Ayeyarwady River and its sub basins is very important and this is the purpose of this paper.