論文

査読有り 国際誌
2020年2月

Cytokine Profiles in Human Parechovirus Type 3-induced Sepsis-like Syndrome.

The Pediatric infectious disease journal
  • Masaki Shimizu
  • ,
  • Hiroyuki Shimizu
  • ,
  • Asumi Jinkawa
  • ,
  • Mari Yamamiya
  • ,
  • Eri Shinozaki
  • ,
  • Tadafumi Yokoyama
  • ,
  • Kazuhide Ohta
  • ,
  • Naoto Sakumura
  • ,
  • Maiko Takakuwa
  • ,
  • Shuhei Fujita
  • ,
  • Shintaro Fusagawa
  • ,
  • Yasuo Nakagishi
  • ,
  • Eri Nariai
  • ,
  • Akihiro Yachie

39
2
開始ページ
137
終了ページ
139
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/INF.0000000000002534

We aimed to assess the kinetics of the release of proinflammatory cytokines and to clarify clinical usefulness as an indicator of the disease activity in human parechovirus type 3 virus (HPeV3)-induced sepsis-like syndrome. We measured serum levels of neopterin, interleukin (IL)-6 and the soluble forms of tumor necrosis factor (TNF) receptor types I (sTNF-RI) and II (sTNF-RII). Serum samples were obtained from 12 patients with HPeV3-induced sepsis-like syndrome and 28 healthy children. Disease course after onset was divided into 3 phases: early (day 1-2), peak (day 3-6) and recovery (day 9-16) phases. Serum IL-6 levels rapidly and markedly elevated in early phase and gradually decreased to those in healthy children in recovery phase. Furthermore, serum neopterin, sTNFR-I and sTNFR-II levels increased rapidly and markedly in onset phase and remained elevated in peak phase. These levels gradually decreased in recovery phase. Serum IL-18 levels increased from onset phase to peak phase and decreased in recovery phase. These results indicate that proinflammatory cytokines, in particular, interferon gamma, TNF-α and IL-18 are closely related to the development of HPeV3-induced sepsis-like syndrome. Serum levels of these cytokines might be a useful indicator of the disease activity.

リンク情報
DOI
https://doi.org/10.1097/INF.0000000000002534
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31929431

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