Yoshihiro Hayashi

Profile Information

Affiliation: Professor, Laboratory of Cancer Pathobiology and Therapeutics, Ritsumeikan University

Degree: 博士（医学）(滋賀医科大学)

ORCID ID: https://orcid.org/0000-0002-1490-9923
J-GLOBAL ID: 201801016003857672
researchmap Member ID: B000344691

External link: https://lab-cpbt2023.ph.ritsumei.ac.jp/

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Professor, Laboratory of Cancer Pathobiology and Therapeutics, Ritsumeikan University
Apr, 2020 - Mar, 2023

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2017 - Mar, 2020

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Sep, 2013 - Mar, 2017

Cincinnati Children's Hospital Medical Center
Apr, 2013 - Aug, 2013

医長, 血液内科, 済生会滋賀県病院
Apr, 2010 - Mar, 2013

Faculty of Medicine, Kyoto University
Apr, 2009 - Mar, 2010

専攻医, 血液内科, 彦根市立病院
Apr, 2007 - Mar, 2009

Shiga University of Medical Science
Apr, 2005 - Mar, 2007

University Hospital, Shiga University of Medical Science

Awards

Oct, 2018

Research Award, Japan Leukaemia Research Fund

Yoshihiro Hayashi
May, 2017

Tito Bastianello Young Investigator Award, International Symposium on Myelodysplastic Syndromes

Yoshihiro Hayashi
Dec, 2016

Abstract Achievement Award, American Society of Hematology

Yoshihiro Hayashi
Dec, 2015

Abstract Achievement Award, American Society of Hematology

Yoshihiro Hayashi
Dec, 2014

Abstract Achievement Award, American Society of Hematology

Yoshihiro Hayashi
Aug, 2014

Christa Muller-Sieburg Award, International Society for Experimental Hematology

Yoshihiro Hayashi
Mar, 2013

President’s Award of Shiga University of Medical Science, Shiga University of Medical Science

Yoshihiro Hayashi
Dec, 2012

Abstract Achievement Award, American Society of Hematology

Yoshihiro Hayashi

Papers

Mitochondrial dynamics as a pathobiological mediator of clonal myeloid disorders.

Yoshihiro Hayashi, Hironori Harada

Cancer science, Apr 7, 2023
The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis.

Naoki Ikeda, Hiroaki Kubota, Risa Suzuki, Mitsuki Morita, Ayana Yoshimura, Yuya Osada, Keigo Kishida, Daiki Kitamura, Ayaka Iwata, Satoshi Yotsumoto …

Cell reports, 42(3) 112165-112165, Feb 28, 2023 Peer-reviewed
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.

Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato …

Nature communications, 14(1) 23-23, Jan 12, 2023
Myeloid neoplasms and clonal hematopoiesis from the RUNX1 perspective

Yoshihiro Hayashi, Yuka Harada, Hironori Harada

Leukemia, 36(5) 1203-1214, Mar 30, 2022
ミトコンドリア異常による骨髄異形成症候群の発症機序

林嘉宏, 原田浩徳

血液内科, 84(3) 375-380, Mar, 2022
Targeting DNMT1 by demethylating agent OR-2100 increases tyrosine kinase inhibitors-sensitivity and depletes leukemic stem cells in chronic myeloid leukemia.

Kazuharu Kamachi, Hiroshi Ureshino, Tatsuro Watanabe, Nao Yoshida, Yuta Yamamoto, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Yoshihiro Hayashi, Hideyo Hirai, Satoshi Yamashita …

Cancer letters, 526 273-283, Feb 1, 2022
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes

Yasushige Aoyagi, Yoshihiro Hayashi, Yuka Harada, Kwangmin Choi, Natsumi Matsunuma, Daichi Sadato, Yuki Maemoto, Akihiro Ito, Shigeru Yanagi, Daniel T Starczynowski …

Cancer Discovery, Aug 30, 2021
Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.

Hiroshi Ureshino, Yuki Kurahashi, Tatsuro Watanabe, Satoshi Yamashita, Kazuharu Kamachi, Yuta Yamamoto, Yuki Fukuda-Kurahashi, Nao Yoshida-Sakai, Naoko Hattori, Yoshihiro Hayashi …

Molecular cancer therapeutics, 20(8) 1412-1421, Aug, 2021
Frontline Science: Conversion of neutrophils into atypical Ly6G+ SiglecF+ immune cells with neurosupportive potential in olfactory neuroepithelium.

Kei Ogawa, Kenichi Asano, Satoshi Yotsumoto, Tsuyoshi Yamane, Makoto Arita, Yoshihiro Hayashi, Hironori Harada, Chieko Makino-Okamura, Hidehiro Fukuyama, Kenji Kondo …

Journal of leukocyte biology, 109(3) 481-496, Mar, 2021
【造血器腫瘍学(第2版)-基礎と臨床の最新研究動向-】骨髄系腫瘍の臨床骨髄異形成症候群骨髄異形成症候群の病態形成における自然免疫系制御異常の役割

林嘉宏, 原田浩徳

日本臨床, 78(増刊3 造血器腫瘍学) 378-383, Aug, 2020
C/EBPβ isoforms sequentially regulate regenerating mouse hematopoietic stem/progenitor cells.

Atsushi Sato, Naoka Kamio, Asumi Yokota, Yoshihiro Hayashi, Akihiro Tamura, Yasuo Miura, Taira Maekawa, Hideyo Hirai

Blood advances, 4(14) 3343-3356, Jul 28, 2020
Rare Neurologic Disease-Associated Mutations of AIMP1 are Related with Inhibitory Neuronal Differentiation Which is Reversed by Ibuprofen.

Yu Takeuchi, Marina Tanaka, Nanako Okura, Yasuyuki Fukui, Ko Noguchi, Yoshihiro Hayashi, Tomohiro Torii, Hiroaki Ooizumi, Katsuya Ohbuchi, Kazushige Mizoguchi …

Medicines (Basel, Switzerland), 7(5), May 6, 2020 Peer-reviewed
Gene Rearrangements of MLL and RUNX1 Sporadically Occur in Normal CD34+ Cells Under Cytokine Stimulation

Yuka Harada, Naoki Shingai, Ye Ding, Daichi Sadato, Yoshihiro Hayashi, Masaki Yamaguchi, Yoshiki Okuyama, Tatsu Shimoyama, Kazuteru Ohashi, Hironori Harada

Cancer Science, Mar 25, 2020 Peer-reviewed
SETD2 mutations confer chemoresistance in acute myeloid leukemia partly through altered cell cycle checkpoints.

Yoshihiro Hayashi

Leukemia, Apr 9, 2019 Peer-reviewed
NUP98-HBO1–fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis

Hayashi Y, Harada Y, Kagiyama Y, Nishikawa S, Ding Y, Imagawa J, Shingai N, Kato N, Kitaura J, Hokaiwado S …

Blood Advances, 3(7) 1047-1060, Apr, 2019 Peer-reviewed
Hypoxia/pseudohypoxia-mediated activation of hypoxia-inducible factor-1α in cancer.

Hayashi Y, Yokota A, Harada H, Huang G

Cancer science, 110(5) 1510-1517, Mar, 2019 Peer-reviewed
C/EBPβ is a critical mediator of IFN-α-induced exhaustion of chronic myeloid leukemia stem cells.

Yokota A, Hirai H, Sato R, Adachi H, Sato F, Hayashi Y, Sato A, Kamio N, Miura Y, Nakano M …

Blood advances, 3(3) 476-488, Feb, 2019 Peer-reviewed
Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes

Yoshihiro Hayashi

Cancer discovery, 8(11) 1438-1457, Nov, 2018 Peer-reviewed
Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation

Yoshihiro Hayashi

Haematologica, 103(7) 1110-1123, Jul, 2018 Peer-reviewed
SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia

Yoshihiro Hayashi

Leukemia, 32(4) 890-899, Apr, 2018 Peer-reviewed

Misc.

Role of HIF1A in the development of myelodysplastic syndromes

HAYASHI Yoshihiro

Rinsho Ketsueki, 60(7) 818-823, 2019
Aberrant Histone Acetylation by HBO1-fusion Generates Clinically Relevant CMML Pathogenesis

Yoshihiro Hayashi, Yuka Harada, Yuki Kagiyama, Naoki Shingai, Norio Komatsu, Hirotaka Matsui, Issay Kitabayashi, Atsushi Iwama, Toshio Kitamura, Hironori Harada

CANCER SCIENCE, 109 743-743, Dec, 2018
NUP98-HBO1によるヒストンアセチル化制御異常は慢性骨髄単球性白血病を引き起こす(NUP98-HBO1 induces clinically relevant CMML pathogenesis through aberrant histone acetylation)

林嘉宏, 原田結花, 鍵山侑希, 丁曄, 今川潤, 新谷直樹, 加藤菜穂子, 北浦次郎, 小松則夫, 松井啓隆 …

臨床血液, 59(9) 1518-1518, Sep, 2018
ヒストンアセチル化制御破綻による慢性骨髄単球性白血病の新規発症機序(Aberrant Histone Acetylation by HBO1-fusion Generates Clinically Relevant CMML Pathogenesis)

林嘉宏, 原田結花, 鍵山侑希, 新谷直樹, 小松則夫, 松井啓隆, 北林一生, 岩間厚志, 北村俊雄, 原田浩徳

日本癌学会総会記事, 77回 1099-1099, Sep, 2018
IFN-α Upregulates the Expression of C/EBPβ and Induces Myeloid Differentiation and Exhaustion of CD34+ CML Stem Cells

Yokota A, Hirai H, Sato A, Kamio N, Hayashi Y, Miura Y, Kimura S, Maekawa T

American Society of Hematology, 59th Annual Meeting and Exposition, Dec, 2017
RNAスプライシング異常が骨髄異形成を起こす機序

林嘉宏, 原田浩徳

月刊血液内科, 75(5) 661‐667-667, Nov 28, 2017
HIF1A is A Critical Mediator for Primary and Secondary Hemophagocytic Lymphohistiocytosis

Gang Huang, Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Jiachen Bu, Jieyu Wang, Yue Zhang, Yile Zhou, Yuting Tang, Lingyun Wu …

PEDIATRIC BLOOD & CANCER, 64 S14-S14, Nov, 2017
IFNα upregulates C/EBPβ in CD34+ CML stem cells and induces their exhaustion.

Yokota A, Hirai H, Sato A, Kamio N, Shoji T, Kashiwagi T, Torikoshi Y, Miura Y, Hayashi Y, Kimura S …

Oct, 2017
Exhaustion of CD34+ CML-CP stem cells is induced by IFNα through upregulation of C/EBPβ

Yokota A, Hirai H, Sato A, Hayashi Y, Miura Y, Kimura S, Maekawa T

第76回日本癌学会学術総会, Sep, 2017
6 HIF1A SIGNALING IS A CENTRAL PATHOBIOLOGIC MEDIATOR OF MDS

Y. Hayashi, Y. Zhang, X. Yan, G. Sashida, K. Chetal, A. Olsson, H. Harada, L. Y. Shih, W. Tse, J. Bridges …

LEUKEMIA RESEARCH, 55 S6-S6, Apr, 2017
SETD2, a H3K36 Lysine Methyltransferase, Is Essential for Adult Normal Hematopoiesis and Leukemia Stem Cells

Yile Zhou, Yunzhu Dong, Jiachen Bu, Xiaomei Yan, Yoshihiro Hayashi, Qianfei Wang, Jie Jin, Gang Huang

BLOOD, 128(22), Dec, 2016
Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, Yoshihiro Hayashi, Mark Wunderlich, Nancy A. Speck, James C. Mulloy, Gang Huang, Yi Zheng

BLOOD, 128(22), Dec, 2016
EPO Signaling Triggers Erythrocytosis By Expanding Erythrocytes and Also Subsets of Macrophages

Yoshihiro Hayashi, Jieyu Wang, Zefeng Xu, Xiaomei Yan, Yue Zhang, Theodosia A. Kalfa, Zhijian Xiao, Gang Huang

BLOOD, 128(22), Dec, 2016
Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis

Jiachen Bu, Aili Chen, Yunzhu Dong, Fuhong He, Xiaomei Yan, Yile Zhou, Di Zhan, Yoshihiro Hayashi, Qianfei Wang, Gang Huang

BLOOD, 128(22), Dec, 2016
Activation of HIF Signaling in Mononuclear Phagocyte System Causes Hemophagocytic Lymphohistiocytosis in C57/BL6 Mice

Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Michael Jordan, Gang Huang

BLOOD, 128(22), Dec, 2016
Blood Specific Activation of HIF-1 alpha/HIF-1 beta Causes HLH Immunopathology in C57BL/6 Mice

Gang Huang, Rui Huang, Yoshihiro Hayashi, Xiaomei Yan, Michael B. Jordan, Alexandra H. Filipovich

PEDIATRIC BLOOD & CANCER, 63 S43-S44, Nov, 2016
C/EBPβ transcription factor promotes exhaustion of CML stem cells in response to interferon-α

Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Miura Y, Nakano M …

The 75th Annual Meeting of Japanese Cancer Association, Oct, 2016
C/EBPβ transcription factor mediates exhaustion of CML stem cells induced by IFNα

Yokota A, Hirai H, Sato A, Tamura A, Shoji T, Kashiwagi T, Fujishiro A, Iwasa M, Miura Y, Hayashi Y …

The 78th Annual Meeting of the Japanese Society of Hematology, Oct, 2016
The C/EBPβ Transcription Factor Mediates the Effect of IFNα on CML Stem Cells Through Promoting Their Differentiation and Exhaustion

Yokota A, Hirai H, Hayashi Y, Sato R, Adachi H, Sato F, Sato A, Tamura A, Iwasa M, Fujishiro A …

The 5th JCA-AACR Special Joint Conference, Jul, 2016
Two Novel Knock-in and Knock-out of Setd2 Alleles Cooperate with MII-Af9 Knock-in Allele to Accelerate Leukemia Development

Yunzhu Dong, Yoshihiro Hayashi, Xiaomei Yan, Feng Xue, Wei Chen, Gang Huang

BLOOD, 126(23), Dec, 2015

Professional Memberships

Research Projects

Targeting immune cells derived from tumor clones in the pathogenesis of hematological malignancy-related systemic organ failure

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
ミトコンドリア動態異常を標的とする骨髄異形成症候群の新規治療法開発

次世代がん医療加速化研究事業研究領域A, 日本医療研究開発機構（AMED）, Apr, 2022 - Mar, 2024
Dysregulated mitochondrial dynamics as an underlying mechanism of MDS bone marrow failure

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2022

Hayashi Yoshihiro
Targeting inflammatory polarization of macrophages and cell surface calreticulin in hemophagocytic lymphohistiocytosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Hayashi Yoshihiro

Profile Information

Research Interests

Research Areas

Research History

Awards

Papers

Misc.

Professional Memberships

Research Projects

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