Tomoyuki Yoshida - My portal

Profile Information

Affiliation: University of Toyama

J-GLOBAL ID: 201101076283158317
researchmap Member ID: B000005197

External link: http://kaken.nii.ac.jp/ja/r/90372367

マウスを用いて中枢シナプス形成の分子機構、更にこの分子機構の破綻に起因する神経発達障害の発病機構について研究しています。

Research Interests

Research Areas

Research History

2013 - Present

Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama
2011 - 2014

さきがけ研究員 (兼任), 科学技術振興機構
2009 - 2012

講師, 東京大学大学院・医学系研究科
2004 - 2009

Graduate School of Medicine, The University of Tokyo

Papers

Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation

Sakurako Goto-Ito, Atsushi Yamagata, Yusuke Sato, Takeshi Uemura, Tomoko Shiroshima, Asami Maeda, Ayako Imai, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai

Nature Communications, 9(1) 269, Dec 1, 2018 Peer-reviewed
Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.

Atsushi Yamagata, Sakurako Goto-Ito, Yusuke Sato, Tomoko Shiroshima, Asami Maeda, Masahiko Watanabe, Takashi Saitoh, Katsumi Maenaka, Tohru Terada, Tomoyuki Yoshida …

Nature communications, 9(1) 3964-3964, Sep 27, 2018 Peer-reviewed
Impairment in extinction of cued fear memory in syntenin-1 knockout mice

Gourango Talukdar, Ran Inoue, Tomoyuki Yoshida, Hisashi Mori

Neurobiology of Learning and Memory, 149 58-67, Mar 1, 2018 Peer-reviewed
Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase

Satoyuki Takahara, Kiyomi Nakagawa, Tsugumi Uchiyama, Tomoyuki Yoshida, Kazunori Matsumoto, Yasuo Kawasumi, Mineyuki Mizuguchi, Takayuki Obita, Yurie Watanabe, Daichi Hayakawa …

Bioorganic and Medicinal Chemistry Letters, 28(3) 441-445, Feb 1, 2018 Peer-reviewed
In situ screening for postsynaptic cell adhesion molecules during synapse formation

Takeshi Uemura, Tomoko Shiroshima, Asami Maeda, Misato Yasumura, Takashi Shimada, Yuko Fukata, Masaki Fukata, Tomoyuki Yoshida

JOURNAL OF BIOCHEMISTRY, 162(4) 295-302, Oct, 2017 Peer-reviewed
A novel serine racemase inhibitor suppresses neuronal over-activation in vivo.

Hisashi Mori, Ryogo Wada, Satoyuki Takahara, Yoshikazu Horino, Hironori Izumi, Tetsuya Ishimoto, Tomoyuki Yoshida, Mineyuki Mizuguchi, Takayuki Obita, Hiroaki Gouda …

Bioorganic & medicinal chemistry, 25(14) 3736-3745, Jul 15, 2017 Peer-reviewed
Neuritin Mediates Activity-Dependent Axonal Branch Formation in Part via FGF Signaling

Tadayuki Shimada, Tomoyuki Yoshida, Kanato Yamagata

JOURNAL OF NEUROSCIENCE, 36(16) 4534-4548, Apr, 2016 Peer-reviewed
Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion

Atsushi Yamagata, Yusuke Sato, Sakurako Goto-Ito, Takeshi Uemura, Asami Maeda, Tomoko Shiroshima, Tomoyuki Yoshida, Shuya Fukai

SCIENTIFIC REPORTS, 5 9686, May, 2015 Peer-reviewed
Phenotypic analysis of IL1RAPL1 knockout mice.

Yasumura M, Yoshida T, Mishina M

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 145(4) 187-192, Apr, 2015 Peer-reviewed
Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation

Atsushi Yamagata, Tomoyuki Yoshida, Yusuke Sato, Sakurako Goto-Ito, Takeshi Uemura, Asami Maeda, Tomoko Shiroshima, Shiho Iwasawa-Okamoto, Hisashi Mori, Masayoshi Mishina …

NATURE COMMUNICATIONS, 6 6926, Apr, 2015 Peer-reviewed
Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?

Ayumi Tanaka-Hayashi, Shuuhei Hayashi, Ran Inoue, Tomokazu Ito, Kohtarou Konno, Tomoyuki Yoshida, Masahiko Watanabe, Tohru Yoshimura, Hisashi Mori

AMINO ACIDS, 47(1) 79-86, Jan, 2015 Peer-reviewed
IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

Misato Yasumura, Tomoyuki Yoshida, Maya Yamazaki, Manabu Abe, Rie Natsume, Kouta Kanno, Takeshi Uemura, Keizo Takao, Kenji Sakimura, Takefumi Kikusui …

SCIENTIFIC REPORTS, 4 6613, Oct, 2014 Peer-reviewed
A590T mutation in KCNQ1 C-terminal helix D decreases I-Ks channel trafficking and function but not Yotiao interaction

Koshi Kinoshita, Takuto Komatsu, Kohki Nishide, Yukiko Hata, Nozomi Hisajima, Hiroyuki Takahashi, Katsuya Kimoto, Kei Aonuma, Eikichi Tsushima, Toshihide Tabata …

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 72 273-280, Jul, 2014 Peer-reviewed
IL1RAPL1 Associated with Mental Retardation and Autism Regulates the Formation and Stabilization of Glutamatergic Synapses of Cortical Neurons through RhoA Signaling Pathway

Takashi Hayashi, Tomoyuki Yoshida, Moonjin Ra, Ryo Taguchi, Masayoshi Mishina

PLOS ONE, 8(6) e66254, Jun, 2013 Peer-reviewed
Molecular mechanism of parallel fiber-Purkinje cell synapse formation

Masayoshi Mishina, Takeshi Uemura, Misato Yasumura, Tomoyuki Yoshida

FRONTIERS IN NEURAL CIRCUITS, 6 90, Nov, 2012 Peer-reviewed
Glutamate receptor delta 1 induces preferentially inhibitory presynaptic differentiation of cortical neurons by interacting with neurexins through cerebellin precursor protein subtypes

Misato Yasumura, Tomoyuki Yoshida, Sung-Jin Lee, Takeshi Uemura, Jae-Yeol Joo, Masayoshi Mishina

JOURNAL OF NEUROCHEMISTRY, 121(5) 705-716, Jun, 2012 Peer-reviewed
GluR delta 2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation

Sung-Jin Lee, Takeshi Uemura, Tomoyuki Yoshida, Masayoshi Mishina

JOURNAL OF NEUROSCIENCE, 32(13) 4688-4701, Mar, 2012 Peer-reviewed
Interleukin-1 Receptor Accessory Protein Organizes Neuronal Synaptogenesis as a Cell Adhesion Molecule

Tomoyuki Yoshida, Tomoko Shiroshima, Sung-Jin Lee, Misato Yasumura, Takeshi Uemura, Xigui Chen, Yoichiro Iwakura, Masayoshi Mishina

JOURNAL OF NEUROSCIENCE, 32(8) 2588-2600, Feb, 2012 Peer-reviewed
Protein tyrosine phosphatase sigma regulates the synapse number of zebrafish olfactory sensory neurons

Xigui Chen, Tomoyuki Yoshida, Hiroshi Sagara, Yoshinori Mikami, Masayoshi Mishina

JOURNAL OF NEUROCHEMISTRY, 119(3) 532-543, Nov, 2011 Peer-reviewed
IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase delta

Tomoyuki Yoshida, Misato Yasumura, Takeshi Uemura, Sung-Jin Lee, Moonjin Ra, Ryo Taguchi, Yoichiro Iwakura, Masayoshi Mishina

JOURNAL OF NEUROSCIENCE, 31(38) 13485-13499, Sep, 2011 Peer-reviewed

Books and Other Publications

分子脳科学

吉田知之 (Role: Joint author, 22章神経回路網とシナプスの形成)

化学同人, 2015
実験医学増刊構造生命科学で何がわかるのか, 何ができるのか.

深井周也, 植村健, 吉田知之

羊土社, 2014