2020年4月15日
Tesmin, Metallothionein-Like 5, is Required for Spermatogenesis in Mice†.
Biology of reproduction
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- 巻
- 102
- 号
- 4
- 開始ページ
- 975
- 終了ページ
- 983
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/biolre/ioaa002
In mammals, more than 2000 genes are specifically or abundantly expressed in testis, but gene knockout studies revealed several are not individually essential for male fertility. Tesmin (Metallothionein-like 5; Mtl5) was originally reported as a testis-specific transcript that encodes a member of the cysteine-rich motif containing metallothionein family. Later studies showed that Tesmin has two splicing variants and both are specifically expressed in male and female germ cells. Herein, we clarified that the long (Tesmin-L) and short (Tesmin-S) transcript forms start expressing from spermatogonia and the spermatocyte stage, respectively, in testis. Furthermore, while Tesmin-deficient female mice are fertile, male mice are infertile due to arrested spermatogenesis at the pachytene stage. We were able to rescue the infertility with a Tesmin-L transgene, where we concluded that TESMIN-L is critical for meiotic completion in spermatogenesis and indispensable for male fertility.
- リンク情報
- ID情報
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- DOI : 10.1093/biolre/ioaa002
- PubMed ID : 31916570
- PubMed Central 記事ID : PMC7124961