Ishima Yu

Last updated: Nov 7, 2018 at 10:56

Name	Ishima Yu
E-mail	ishima.yuutokushima-u.ac.jp
Affiliation	The University of Tokushima

Research Areas

Pharmacy / Medical pharmacy /

Published Papers

Plain Text

Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions.

Minayoshi Y, Maeda H, Yanagisawa H, Hamasaki K, Mizuta Y, Nishida K, Kinoshita R, Enoki Y, Imafuku T, Chuang VTG, Koga T, Fujiwara Y, Takeya M, Sonoda K, Wakayama T, Taguchi K, Ishima Y, Ishida T, Iwakiri Y, Tanaka M, Sasaki Y, Watanabe H, Otagiri M, Maruyama T

Drug delivery 25(1) 1067-1077 Nov 2018 [Refereed]

A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics.

Shimizu T, Abu Lila AS, Awata M, Kubo Y, Mima Y, Hashimoto Y, Ando H, Okuhira K, Ishima Y, Ishida T

Pharmaceutical research 35(11) 223 Oct 2018 [Refereed]

Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways.

Emam SE, Ando H, Lila ASA, Shimizu T, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Sagawa I, Ishida T

Scientific reports 8(1) 14493 Sep 2018 [Refereed]

A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes.

Shimizu T, Abu Lila AS, Fujita R, Awata M, Kawanishi M, Hashimoto Y, Okuhira K, Ishima Y, Ishida T

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 127 142-149 Jun 2018 [Refereed]

Modeling of the Weight Status and Risk of Nonalcoholic Fatty Liver Disease in Elderly Individuals: The Potential Impact of the Disulfide Bond-Forming Oxidoreductase A-Like Protein (DsbA-L) Polymorphism on the Weight Status.

Oniki K, Watanabe T, Kudo M, Izuka T, Ono T, Matsuda K, Sakamoto Y, Nagaoka K, Imafuku T, Ishima Y, Watanabe H, Maruyama T, Otake K, Ogata Y, Saruwatari J

CPT: pharmacometrics & systems pharmacology 7(6) 384-393 Jun 2018 [Refereed]

Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery.

Ichimizu S, Watanabe H, Maeda H, Hamasaki K, Nakamura Y, Chuang VTG, Kinoshita R, Nishida K, Tanaka R, Enoki Y, Ishima Y, Kuniyasu A, Kobashigawa Y, Morioka H, Futaki S, Otagiri M, Maruyama T

Journal of controlled release : official journal of the Controlled Release Society 277 23-34 May 2018 [Refereed]

A novel S-sulfhydrated human serum albumin preparation suppresses melanin synthesis.

Ikeda M, Ishima Y, Kinoshita R, Chuang VTG, Tasaka N, Matsuo N, Watanabe H, Shimizu T, Ishida T, Otagiri M, Maruyama T

Redox biology 14 354-360 Apr 2018 [Refereed]

Dual Therapeutic Effects of an Albumin-Based Nitric Oxide Donor on 2 Experimental Models of Chronic Kidney Disease.

Oshiro S, Ishima Y, Maeda H, Honda N, Bi J, Kinoshita R, Ikeda M, Iwao Y, Imafuku T, Nishida K, Miyamura S, Watanabe H, Otagiri M, Maruyama T

Journal of pharmaceutical sciences 107(3) 848-855 Mar 2018 [Refereed]

Intratumoral Visualization of Oxaliplatin within a Liposomal Formulation Using X-ray Fluorescence Spectrometry.

Ando H, Abu Lila AS, Tanaka M, Doi Y, Terada Y, Yagi N, Shimizu T, Okuhira K, Ishima Y, Ishida T

Molecular pharmaceutics 15(2) 403-409 Feb 2018 [Refereed]

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity.

Tanaka KI, Shimoda M, Chuang VTG, Nishida K, Kawahara M, Ishida T, Otagiri M, Maruyama T, Ishima Y

International journal of pharmaceutics 535(1-2) 140-147 Jan 2018 [Refereed]

Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens.

Ando H, Abu Lila AS, Kawanishi M, Shimizu T, Okuhira K, Ishima Y, Ishida T

Journal of controlled release : official journal of the Controlled Release Society 270 114-119 Jan 2018 [Refereed]

A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.

Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T

Biological & pharmaceutical bulletin 41(5) 733-742 2018 [Refereed]

Doxorubicin Expands in Vivo Secretion of Circulating Exosome in Mice.

Emam SE, Ando H, Abu Lila AS, Kobayashi S, Shimizu T, Okuhira K, Ishima Y, Ishida T

Biological & pharmaceutical bulletin 41(7) 1078-1083 2018 [Refereed]

Parathyroid hormone contributes to the down-regulation of cytochrome P450 3A through the cAMP/PI3K/PKC/PKA/NF-κB signaling pathway in secondary hyperparathyroidism.

Watanabe H, Sugimoto R, Ikegami K, Enoki Y, Imafuku T, Fujimura R, Bi J, Nishida K, Sakaguchi Y, Murata M, Maeda H, Hirata K, Jingami S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T

Biochemical pharmacology 145 192-201 Dec 2017 [Refereed]

Potential therapeutic interventions for chronic kidney disease-associated sarcopenia via indoxyl sulfate-induced mitochondrial dysfunction.

Enoki Y, Watanabe H, Arake R, Fujimura R, Ishiodori K, Imafuku T, Nishida K, Sugimoto R, Nagao S, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T

Journal of cachexia, sarcopenia and muscle 8(5) 735-747 Oct 2017 [Refereed]

Apoptosis induction of poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition.

Ikeda M, Ishima Y, Chuang VTG, Ikeda T, Kinoshita R, Watanabe H, Ishida T, Otagiri M, Maruyama T

Nitric oxide : biology and chemistry 69 28-34 Sep 2017 [Refereed]

Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model.

Shimizu T, Abu Lila AS, Nishio M, Doi Y, Ando H, Ukawa M, Ishima Y, Ishida T

Cancer science 108(9) 1864-1869 Sep 2017 [Refereed]

Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer.

Kinoshita R, Ishima Y, Chuang VTG, Nakamura H, Fang J, Watanabe H, Shimizu T, Okuhira K, Ishida T, Maeda H, Otagiri M, Maruyama T

Biomaterials 140 162-169 Sep 2017 [Refereed]

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

Ikeda M, Ishima Y, Shibata A, Chuang VTG, Sawa T, Ihara H, Watanabe H, Xian M, Ouchi Y, Shimizu T, Ando H, Ukawa M, Ishida T, Akaike T, Otagiri M, Maruyama T

Analytica chimica acta 969 18-25 May 2017 [Refereed]

Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism.

Sugimoto R, Watanabe H, Ikegami K, Enoki Y, Imafuku T, Sakaguchi Y, Murata M, Nishida K, Miyamura S, Ishima Y, Tanaka M, Matsushita K, Komaba H, Fukagawa M, Otagiri M, Maruyama T

Kidney international 91(3) 658-670 Mar 2017 [Refereed]

Albumin-Based Nitric Oxide Traffic System for the Treatment of Intractable Cancers.

Ishima Y

Biological & pharmaceutical bulletin 40(2) 128-134 2017 [Refereed]

Recombinant Human Serum Albumin Containing 3 Copies of Domain I, Has Significant in Vitro Antioxidative Capacity Compared to the Wild-Type.

Matsushita S, Nishi K, Iwao Y, Ishima Y, Watanabe H, Taguchi K, Yamasaki K, Maruyama T, Otagiri M

Biological & pharmaceutical bulletin 40(10) 1813-1817 2017 [Refereed]

Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease.

Shibata A, Ishima Y, Ikeda M, Sato H, Imafuku T, Chuang VTG, Ouchi Y, Abe T, Watanabe H, Ishida T, Otagiri M, Maruyama T

Biochemical and biophysical research communications 479(3) 578-583 Oct 2016 [Refereed]

Indoxyl sulfate potentiates skeletal muscle atrophy by inducing the oxidative stress-mediated expression of myostatin and atrogin-1.

Enoki Y, Watanabe H, Arake R, Sugimoto R, Imafuku T, Tominaga Y, Ishima Y, Kotani S, Nakajima M, Tanaka M, Matsushita K, Fukagawa M, Otagiri M, Maruyama T

Scientific reports 6 32084 Aug 2016 [Refereed]

Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia.

Kragh-Hansen U, Minchiotti L, Coletta A, Bienk K, Galliano M, Schiøtt B, Iwao Y, Ishima Y, Otagiri M

Biochimica et biophysica acta 1860(4) 648-660 Apr 2016 [Refereed]

Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations.

Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T

Journal of pharmaceutical sciences 105(3) 1043-1049 Mar 2016 [Refereed]

[Human Serum Albumin as Carrier in Drug Delivery Systems].

Ishima Y, Maruyama T

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 136(1) 39-47 2016 [Refereed]

Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study.

Tanaka M, Miyamura S, Imafuku T, Tominaga Y, Maeda H, Anraku M, Yamasaki K, Kadowaki D, Ishima Y, Watanabe H, Okuda T, Itoh K, Matsushita K, Fukagawa M, Otagiri M, Maruyama T

Biological & pharmaceutical bulletin 39(6) 1000-1006 2016 [Refereed]

S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes.

Kinoshita R, Ishima Y, Ikeda M, Kragh-Hansen U, Fang J, Nakamura H, Chuang VT, Tanaka R, Maeda H, Kodama A, Watanabe H, Maeda H, Otagiri M, Maruyama T

Journal of controlled release : official journal of the Controlled Release Society 217 1-9 Nov 2015 [Refereed]

Kupffer cell inactivation by carbon monoxide bound to red blood cells preserves hepatic cytochrome P450 via anti-oxidant and anti-inflammatory effects exerted through the HMGB1/TLR-4 pathway during resuscitation from hemorrhagic shock.

Ogaki S, Taguchi K, Maeda H, Watanabe H, Ishima Y, Otagiri M, Maruyama T

Biochemical pharmacology 97(3) 310-319 Oct 2015 [Refereed]

Nitration of indoxyl sulfate facilitates its cytotoxicity in human renal proximal tubular cells via expression of heme oxygenase-1.

Ishima Y, Narisoko T, Kragh-Hansen U, Kotani S, Nakajima M, Otagiri M, Maruyama T

Biochemical and biophysical research communications 465(3) 481-487 Sep 2015 [Refereed]

Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury.

Nishida K, Watanabe H, Ogaki S, Kodama A, Tanaka R, Imafuku T, Ishima Y, Chuang VT, Toyoda M, Kondoh M, Wu Q, Fukagawa M, Otagiri M, Maruyama T

Scientific reports 5 14471 Sep 2015 [Refereed]

Polythiol-containing, recombinant mannosylated-albumin is a superior CD68+/CD206+ Kupffer cell-targeted nanoantioxidant for treatment of two acute hepatitis models.

Maeda H, Hirata K, Watanabe H, Ishima Y, Chuang VT, Taguchi K, Inatsu A, Kinoshita M, Tanaka M, Sasaki Y, Otagiri M, Maruyama T

The Journal of pharmacology and experimental therapeutics 352(2) 244-257 Feb 2015 [Refereed]

Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy through the generation of nitric oxide.

Ishima Y, Inoue A, Fang J, Kinoshita R, Ikeda M, Watanabe H, Maeda H, Otagiri M, Maruyama T

Cancer science 106(2) 194-200 Feb 2015 [Refereed]

p-Cresyl sulfate, a uremic toxin, causes vascular endothelial and smooth muscle cell damages by inducing oxidative stress.

Watanabe H, Miyamoto Y, Enoki Y, Ishima Y, Kadowaki D, Kotani S, Nakajima M, Tanaka M, Matsushita K, Mori Y, Kakuta T, Fukagawa M, Otagiri M, Maruyama T

Pharmacology research & perspectives 3(1) e00092 Feb 2015 [Refereed]

Pleiotropic Effects of Levofloxacin, Fluoroquinolone Antibiotics, against Influenza Virus-Induced Lung Injury.

Enoki Y, Ishima Y, Tanaka R, Sato K, Kimachi K, Shirai T, Watanabe H, Chuang VT, Fujiwara Y, Takeya M, Otagiri M, Maruyama T

PloS one 10(6) e0130248 2015 [Refereed]

Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia.

Miyazaki Y, Taguchi K, Sou K, Watanabe H, Ishima Y, Miyakawa T, Mitsuya H, Fukagawa M, Otagiri M, Maruyama T

Molecular pharmaceutics 11(11) 4238-4248 Nov 2014 [Refereed]

Human organic anion transporters function as a high-capacity transporter for p-cresyl sulfate, a uremic toxin.

Watanabe H, Sakaguchi Y, Sugimoto R, Kaneko K, Iwata H, Kotani S, Nakajima M, Ishima Y, Otagiri M, Maruyama T

Clinical and experimental nephrology 18(5) 814-820 Oct 2014 [Refereed]

Possible false-negative results on therapeutic drug monitoring of phenytoin using a particle enhanced turbidimetric inhibition immunoassay in a patient with a high level of IgM.

Hirata K, Saruwatari J, Enoki Y, Iwata K, Urata Y, Aizawa K, Ueda K, Shirouzono T, Imamura M, Moriuchi H, Ishima Y, Kadowaki D, Watanabe H, Hirata S, Maruyama T, Fukunaga E

Therapeutic drug monitoring 36(5) 553-555 Oct 2014 [Refereed]

N-acetyl-l-methionine is a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan.

Kouno Y, Anraku M, Yamasaki K, Okayama Y, Iohara D, Ishima Y, Maruyama T, Kragh-Hansen U, Hirayama F, Otagiri M

Biochimica et biophysica acta 1840(9) 2806-2812 Sep 2014 [Refereed]

Tuning of poly-S-nitrosated human serum albumin as superior antitumor nanomedicine.

Ishima Y, Fang J, Kragh-Hansen U, Yin H, Liao L, Katayama N, Watanabe H, Kai T, Suenaga A, Maeda H, Otagiri M, Maruyama T

Journal of pharmaceutical sciences 103(7) 2184-2188 Jul 2014 [Refereed]

Carbon monoxide-bound red blood cell resuscitation ameliorates hepatic injury induced by massive hemorrhage and red blood cell resuscitation via hepatic cytochrome P450 protection in hemorrhagic shock rats.

Ogaki S, Taguchi K, Watanabe H, Ishima Y, Otagiri M, Maruyama T

Journal of pharmaceutical sciences 103(7) 2199-2206 Jul 2014 [Refereed]

Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis.

Tanaka R, Ishima Y, Maeda H, Kodama A, Nagao S, Watanabe H, Chuang VT, Otagiri M, Maruyama T

Molecular pharmaceutics 11(4) 1228-1238 Apr 2014 [Refereed]

Albumin fusion renders thioredoxin an effective anti-oxidative and anti-inflammatory agent for preventing cisplatin-induced nephrotoxicity.

Kodama A, Watanabe H, Tanaka R, Kondo M, Chuang VT, Wu Q, Endo M, Ishima Y, Fukagawa M, Otagiri M, Maruyama T

Biochimica et biophysica acta 1840(3) 1152-1162 Mar 2014 [Refereed]

Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases.

Nagumo K, Tanaka M, Chuang VT, Setoyama H, Watanabe H, Yamada N, Kubota K, Tanaka M, Matsushita K, Yoshida A, Jinnouchi H, Anraku M, Kadowaki D, Ishima Y, Sasaki Y, Otagiri M, Maruyama T

PloS one 9(1) e85216 2014 [Refereed]

Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin.

Sato H, Chuang VT, Yamasaki K, Yamaotsu N, Watanabe H, Nagumo K, Anraku M, Kadowaki D, Ishima Y, Hirono S, Otagiri M, Maruyama T

PloS one 9(2) e87919 2014 [Refereed]

Therapeutic impact of human serum albumin-thioredoxin fusion protein on influenza virus-induced lung injury mice.

Tanaka R, Ishima Y, Enoki Y, Kimachi K, Shirai T, Watanabe H, Chuang VT, Maruyama T, Otagiri M

Frontiers in immunology 5 561 2014 [Refereed]

Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.

Tanaka R, Watanabe H, Kodama A, Chuang VT, Ishima Y, Hamasaki K, Tanaka K, Mizushima T, Otagiri M, Maruyama T

The Journal of pharmacology and experimental therapeutics 345(2) 271-283 May 2013 [Refereed]

p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase.

Watanabe H, Miyamoto Y, Honda D, Tanaka H, Wu Q, Endo M, Noguchi T, Kadowaki D, Ishima Y, Kotani S, Nakajima M, Kataoka K, Kim-Mitsuyama S, Tanaka M, Fukagawa M, Otagiri M, Maruyama T

Kidney international 83(4) 582-592 Apr 2013 [Refereed]

Albumin domain II mutant with high bilirubin binding affinity has a great potential as serum bilirubin excretion enhancer for hyperbilirubinemia treatment.

Minomo A, Ishima Y, Chuang VT, Suwa Y, Kragh-Hansen U, Narisoko T, Morioka H, Maruyama T, Otagiri M

Biochimica et biophysica acta 1830(4) 2917-2923 Apr 2013 [Refereed]

UW solution improved with high anti-apoptotic activity by S-nitrosated human serum albumin.

Ishima Y, Shinagawa T, Yoneshige S, Kragh-Hansen U, Ohya Y, Inomata Y, Kai T, Otagiri M, Maruyama T

Nitric oxide : biology and chemistry 30 36-42 Apr 2013 [Refereed]

A human serum albumin-thioredoxin fusion protein prevents experimental contrast-induced nephropathy.

Kodama A, Watanabe H, Tanaka R, Tanaka H, Chuang VT, Miyamoto Y, Wu Q, Endo M, Hamasaki K, Ishima Y, Fukagawa M, Otagiri M, Maruyama T

Kidney international 83(3) 446-454 Mar 2013 [Refereed]

S-nitrosated α-1-acid glycoprotein kills drug-resistant bacteria and aids survival in sepsis.

Watanabe K, Ishima Y, Akaike T, Sawa T, Kuroda T, Ogawa W, Watanabe H, Suenaga A, Kai T, Otagiri M, Maruyama T

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 27(1) 391-398 Jan 2013 [Refereed]

Poly-s-nitrosated albumin as a safe and effective multifunctional antitumor agent: characterization, biochemistry and possible future therapeutic applications.

Ishima Y, Kragh-Hansen U, Maruyama T, Otagiri M

BioMed research international 2013 353892 2013 [Refereed]

A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate.

Miyamoto Y, Iwao Y, Mera K, Watanabe H, Kadowaki D, Ishima Y, Chuang VT, Sato K, Otagiri M, Maruyama T

Biochemical pharmacology 84(9) 1207-1214 Nov 2012 [Refereed]

Elucidation of the therapeutic enhancer mechanism of poly-S-nitrosated human serum albumin against multidrug-resistant tumor in animal models.

Ishima Y, Hara M, Kragh-Hansen U, Inoue A, Suenaga A, Kai T, Watanabe H, Otagiri M, Maruyama T

Journal of controlled release : official journal of the Controlled Release Society 164(1) 1-7 Nov 2012 [Refereed]

S-guanylation of human serum albumin is a unique posttranslational modification and results in a novel class of antibacterial agents.

Ishima Y, Hoshino H, Shinagawa T, Watanabe K, Akaike T, Sawa T, Kragh-Hansen U, Kai T, Watanabe H, Maruyama T, Otagiri M

Journal of pharmaceutical sciences 101(9) 3222-3229 Sep 2012 [Refereed]

Interaction between two sulfate-conjugated uremic toxins, p-cresyl sulfate and indoxyl sulfate, during binding with human serum albumin.

Watanabe H, Noguchi T, Miyamoto Y, Kadowaki D, Kotani S, Nakajima M, Miyamura S, Ishima Y, Otagiri M, Maruyama T

Drug metabolism and disposition: the biological fate of chemicals 40(7) 1423-1428 Jul 2012 [Refereed]

Quantitative evaluation of the role of cysteine and methionine residues in the antioxidant activity of human serum albumin using recombinant mutants.

Iwao Y, Ishima Y, Yamada J, Noguchi T, Kragh-Hansen U, Mera K, Honda D, Suenaga A, Maruyama T, Otagiri M

IUBMB life 64(5) 450-454 May 2012 [Refereed]

S-Nitrosated human serum albumin dimer is not only a novel anti-tumor drug but also a potentiator for anti-tumor drugs with augmented EPR effects.

Ishima Y, Chen D, Fang J, Maeda H, Minomo A, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M

Bioconjugate chemistry 23(2) 264-271 Feb 2012 [Refereed]

Biological characteristics of two lysines on human serum albumin in the high-affinity binding of 4Z,15Z-bilirubin-IXα revealed by phage display.

Minomo A, Ishima Y, Kragh-Hansen U, Chuang VT, Uchida M, Taguchi K, Watanabe H, Maruyama T, Morioka H, Otagiri M

The FEBS journal 278(21) 4100-4111 Nov 2011 [Refereed]

Cellular uptake mechanisms and responses to NO transferred from mono- and poly-S-nitrosated human serum albumin.

Ishima Y, Yoshida F, Kragh-Hansen U, Watanabe K, Katayama N, Nakajou K, Akaike T, Kai T, Maruyama T, Otagiri M

Free radical research 45(10) 1196-1206 Oct 2011 [Refereed]

Human serum albumin-thioredoxin fusion protein with long blood retention property is effective in suppressing lung injury.

Furukawa M, Tanaka R, Chuang VT, Ishima Y, Taguchi K, Watanabe H, Maruyama T, Otagiri M

Journal of controlled release : official journal of the Controlled Release Society 154(2) 189-195 Sep 2011 [Refereed]

Albumin fusion of thioredoxin--the production and evaluation of its biological activity for potential therapeutic applications.

Ikuta S, Chuang VT, Ishima Y, Nakajou K, Furukawa M, Watanabe H, Maruyama T, Otagiri M

Journal of controlled release : official journal of the Controlled Release Society 147(1) 17-23 Oct 2010 [Refereed]

One-step preparation of S-nitrosated human serum albumin with high biological activities.

Ishima Y, Hiroyama S, Kragh-Hansen U, Maruyama T, Sawa T, Akaike T, Kai T, Otagiri M

Nitric oxide : biology and chemistry 23(2) 121-127 Sep 2010 [Refereed]

Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.

Hirata K, Maruyama T, Watanabe H, Maeda H, Nakajou K, Iwao Y, Ishima Y, Katsumi H, Hashida M, Otagiri M

Journal of controlled release : official journal of the Controlled Release Society 145(1) 9-16 Jul 2010 [Refereed]

The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions.

Miyamoto Y, Iwao Y, Tasaki Y, Sato K, Ishima Y, Watanabe H, Kadowaki D, Maruyama T, Otagiri M

FEBS letters 584(13) 2816-2820 Jul 2010 [Refereed]

The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.

Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T

The Journal of biological chemistry 285(31) 23970-23984 Jul 2010 [Refereed]

Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells.

Katayama N, Nakajou K, Ishima Y, Ikuta S, Yokoe J, Yoshida F, Suenaga A, Maruyama T, Kai T, Otagiri M

Nitric oxide : biology and chemistry 22(4) 259-265 May 2010 [Refereed]

Albumin as a nitric oxide-traffic protein: characterization, biochemistry and possible future therapeutic applications.

Ishima Y, Kragh-Hansen U, Maruyama T, Otagiri M

Drug metabolism and pharmacokinetics 24(4) 308-317 2009 [Refereed]

S-nitrosylated human serum albumin-mediated cytoprotective activity is enhanced by fatty acid binding.

Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Suenaga A, Maruyama T, Kai T, Otagiri M

The Journal of biological chemistry 283(50) 34966-34975 Dec 2008 [Refereed]

Effects of endogenous ligands on the biological role of human serum albumin in S-nitrosylation.

Ishima Y, Akaike T, Kragh-Hansen U, Hiroyama S, Sawa T, Maruyama T, Kai T, Otagiri M

Biochemical and biophysical research communications 364(4) 790-795 Dec 2007 [Refereed]

S-Nitrosylation of human variant albumin Liprizzi (R410C) confers potent antibacterial and cytoprotective properties.

Ishima Y, Sawa T, Kragh-Hansen U, Miyamoto Y, Matsushita S, Akaike T, Otagiri M

The Journal of pharmacology and experimental therapeutics 320(3) 969-977 Mar 2007 [Refereed]

Effect of nitric oxide in amyloid fibril formation on transthyretin-related amyloidosis.

Saito S, Ando Y, Nakamura M, Ueda M, Kim J, Ishima Y, Akaike T, Otagiri M

Biochemistry 44(33) 11122-11129 Aug 2005 [Refereed]

Association Memberships

THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM(115) , THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN(127) , THE PHARMACEUTICAL SOCIETY OF JAPAN(1808)