Ishima Yu

Profile Information

Affiliation: Professor, Department of Biopharmaceutics, Kyoto Pharmaceutical University

Degree: Ph.D.(Mar, 2007, Kumamoto University)

J-GLOBAL ID: 201801019051358881
researchmap Member ID: B000320827

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Professor, Department of Biopharmaceutics, Kyoto Pharmaceutical University
2016 - Mar, 2023

Tokushima University
2011 - 2016

School of Pharmacy, Kumamoto University
2010 - 2011

Pharmacology & chemicalbiology, University of Pittsburgh
2007 - 2011

School of Pharmacy, Kumamoto University

Education

Apr, 2004 - Mar, 2007

熊本大学大学院薬学教育部博士後期課程
Apr, 2002 - Mar, 2004

熊本大学大学院薬学研究科博士前期課程
Apr, 1998 - Mar, 2002

熊本大学薬学部薬科学科

Committee Memberships

Awards

Papers

162

Carbon Monoxide Alleviates Post-ischemia–reperfusion Skeletal Muscle Injury and Systemic Inflammation

Kazuaki Taguchi, Shigeru Ogaki, Hitoshi Maeda, Yu Ishima, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama

Biological and Pharmaceutical Bulletin, 47(4) 868-871, Apr 20, 2024 Peer-reviewed
Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Victor Tuan Giam Chuang, Ming Xian, Tatsuhiro Ishida, Takaaki Akaike, Yu Ishima

Advances in Redox Research, 10, Apr, 2024 Peer-reviewed
The binding selectivity of quercetin and its structure-related polyphenols to human serum albumin using a fluorescent dye cocktail for multiplex drug-site mapping

Rie Mukai, Hitomi Okuyama, Miku Uchimura, Kozue Sakao, Miyu Matsuhiro, Mayumi Ikeda-Imafuku, Yu Ishima, Miyu Nishikawa, Shinichi Ikushiro, Akihiro Tai

Bioorganic Chemistry, 107184-107184, Feb, 2024 Peer-reviewed
Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways.

Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida, Yu Ishima

Pharmaceuticals (Basel, Switzerland), 17(1), Jan 18, 2024 Peer-reviewed
Peritoneal B Cells Play a Role in the Production of Anti-polyethylene Glycol (PEG) IgM against Intravenously Injected siRNA-PEGylated Liposome Complexes.

Taro Shimizu, Amr S Abu Lila, Yuka Kitayama, Ryo Abe, Haruka Takata, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida

Biological & pharmaceutical bulletin, 47(2) 469-477, 2024 Peer-reviewed
血清アルブミンに存在する超硫黄の解析と創薬応用

Mayumi Ikeda, Tatsuya Fukuta, Yasunori Iwao, Masaki Otagiri, Toru Maruyama, Tatsuhiro Ishida, Yu Ishima

YAKUGAKU ZASSHI, 144(1) 51-56, Jan 1, 2024 Peer-reviewed
Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis

Kengo Yasuda, Hitoshi Maeda, Ryo Kinoshita, Yuki Minayoshi, Yuki Mizuta, Yuka Nakamura, Shuhei Imoto, Koji Nishi, Keishi Yamasaki, Mina Sakuragi …

ACS Nano, Aug 14, 2023 Peer-reviewed
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route.

Haruka Takata, Taro Shimizu, Rina Yamade, Nehal E Elsadek, Sherif E Emam, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida

Journal of controlled release : official journal of the Controlled Release Society, 360 285-292, Jun 29, 2023 Peer-reviewed
Effectiveness of Albumin-Fused Thioredoxin against 6-Hydroxydopamine-Induced Neurotoxicity In Vitro.

Okina Sakakibara, Mikako Shimoda, Gaku Yamamoto, Youichirou Higashi, Mayumi Ikeda-Imafuku, Yu Ishima, Masahiro Kawahara, Ken-Ichiro Tanaka

International journal of molecular sciences, 24(11), Jun 5, 2023 Peer-reviewed
Ionic liquid-based transcutaneous peptide antitumor vaccine; therapeutic effect in a mouse tumor model

Shimizu Taro, Matsuzaki Takaaki, Fukuda Shoishiro, Yoshioka Chihiro, Shimazaki Yuna, Takese Shunsuke, Yamanaka Katsuhiro, Nakae Takashi, Ishibashi Masaki, Hamamoto Hidetoshi …

The AAPS J, Vol.25(No.2) 27-27, Mar, 2023 Peer-reviewed
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice

Ibrahim Mohamed, Shimizu Taro, ANDO Hidenori, Ishima Yu, Elgarhy Omar Helmy, Sarhan Hatem A, Hussein Amal K, Ishida Tatsuhiro

Journal of Controlled Release, Vol.354 260-267, Feb 1, 2023 Peer-reviewed
FTY720 reduces lipid accumulation by upregulating ABCA1 through liver X receptor and sphingosine kinase 2 signaling in macrophages

Tachibana Kohki, Kusumoto Kohshi, Ogawa Mai, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro, Okuhira Keiichiro

International Journal of Molecular Sciences, Vol.23(23) 14617-14617, Nov 23, 2022 Peer-reviewed
アルブミンのボリスルフィドによる新たな生体恒常性維持機構

Ishima Yu, 小田切優樹, Ishida Tatsuhiro

人工血液, Vol.30(1) 59-64, Nov 1, 2022 Peer-reviewed
Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts.

Takuro Beppu, Koji Nishi, Shuhei Imoto, Waka Araki, Itaru Setoguchi, Ayaka Ueda, Naho Suetsugi, Yu Ishima, Tokunori Ikeda, Masaki Otagiri …

Oncology reports, 48(4), Oct, 2022 Peer-reviewed
A maleimide-terminally modified PEGylated liposome induced the accelerated blood clearance independent of the production of anti-PEG IgM antibodies

Ishima Yu, Yamazaki Nio, Chuang V, Shimizu Taro, ANDO Hidenori, Ishida Tatsuhiro

Biological & Pharmaceutical Bulletin, Vol.45(No.10) 1518-1524, Oct 1, 2022 Peer-reviewed
Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment

ANDO Hidenori, Ikeda Ai, Tagami Maho, Matsuo Nana, Shimizu Taro, Ishima Yu, Eshima K, Ishida Tatsuhiro

Journal of Controlled Release, Vol.350 414-420, Aug 18, 2022 Peer-reviewed
Development of a nanocarrier-based splenic B cell-targeting system for loading antigens in vitro

Kawaguchi Yoshino, Shimizu Taro, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

Biological & Pharmaceutical Bulletin, Vol.45(No.7) 926-933, Jul 1, 2022 Peer-reviewed
Development of an antigen delivery system for a B cell-targeted vaccine as an alternative to dendritic cell-targeted vaccines

Shimizu Taro, Kawaguchi Yoshino, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

Chemical & Pharmaceutical Bulletin, Vol.70(No.5) 341-350, May 1, 2022 Peer-reviewed
Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice

Nakajima Takaki, Nagano Kazuya, Fukuda Yuka, Ishima Yu, Shibata Hiroko, Isaka Ryo, Zhang Tian-Qi, Haga Yuya, Higashisaka Kazuma, Tsujino Hirofumi …

Journal of Pharmaceutical Sciences, Vol.111(No.5) 1363-1369, May 1, 2022 Peer-reviewed
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes

El Sayed Marwa, Shimizu Taro, Amr Selim Ahmed Ali Abu Lila, Nehal Emam Elsadek Emam Ali Elhewan, Sherif Emam Abdallah Emam, Alaaeldin Eman, Kamal Amal, Sarhan Hatem, ANDO Hidenori, Ishima Yu …

International Journal of Pharmaceutics, Vol.615 121539-121539, Mar 5, 2022 Peer-reviewed

Misc.

From the Past to the Future of Focus Group: Focus Group on Supramolecular Pharmaceutics

Kawakami Shigeru, Ishima Yu, Arima Hidetoshi, Yamayoshi Asako, Fumoto Shintaro

Journal of Pharmaceutical Science and Technology, Japan, 84(2) 66-70, 2024
アルブミン受容体を生かした薬物送達—アルブミン介在性細胞内薬物送達促進メカニズムの全容解明に挑む

異島優

ファルマシア, 59(10) 898-902, 2023
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products

Mohamed Ibrahim, Abdelhameed Mostafa Ramadan Eslam, Elhewan Ali Emam Elsadek Emam Nehal, Emam Abdallah Emam Sherif, Shimizu Taro, ANDO Hidenori, Ishima Yu, Omar Helmy Elgarhy, Hatem A Sarhan, Amal K Hussein …

Journal of Controlled Release, Vol.351 215-230, Nov, 2022
The challenge to deliver oxaliplatin (l-OHP) to solid tumors: development of liposomal l-OHP formulations

Matsuo Nana, ANDO Hidenori, Doi Yusuke, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

Chemical & Pharmaceutical Bulletin, Vol.70(No.5) 351-358, May 1, 2022
The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors

Ishima Yu, Maruyama Toru, Otagiri Masaki, Chuang Victor T G, Ishida Tatsuhiro

Chemical & Pharmaceutical Bulletin, Vol.70(No.5) 330-333, May 1, 2022
Development of a novel method for albumin-based nanoparticle preparation using sulfosalicylic acid for the treatment of sepsis

TOTTORI Yukina, HIRAKAWA Naoki, KINOSHITA Ryo, SHIMIZU Taro, ANDO Hidenori, ISHIDA Tatsuhiro, ISHIMA Yu

Annual Meeting of the Japanese Society of Toxicology, 49.1 O-13, 2022
Functional elucidation of supersulfide in human hair

HIRAI Takeru, SHIMIZU Tarou, ANDO Hidenori, ISHIDA Tatsuhiro, ISHIMA Yu

Annual Meeting of the Japanese Society of Toxicology, 49.1 O-12, 2022
Detection of supersulfide contained in the stratum corneum of the skin

HASHIMOTO Reina, SHIMIZU Taro, ANDO Hidenori, ISHIDA Tatsuhiro, ISHIMA Yu

Annual Meeting of the Japanese Society of Toxicology, 49.1 O-3, 2022
Protective effects of human serum albumin treatment in experimental endotoxic shock

MUKAI Aina, SHIMIZU Taro, ANDO Hidenori, ISHIDA Tatsuhiro, ISHIMA Yu

Annual Meeting of the Japanese Society of Toxicology, 49.1 O-11, 2022
Report on the 2nd Symposium by the Focus Group on Supramolecular Pharmaceutics

Ishima Yu

Journal of Pharmaceutical Science and Technology, Japan, 82(1) 56-57, 2022
Preparation of cyclosporine A containing nano-fibrillated bacterial cellulose and its application for the treatment of psoriasis

高田春風, 安藤英紀, 田島健次, 清水太郎, 異島優, 松島得雄, 草野貴友, 石田竜弘

セルロース学会年次大会講演要旨集, 29th, 2022
Evaluation of the effect of orally administrated nano-fibrillated bacterial cellulose (NFBC) to regulate construction of gut microbiota and prevent obesity

川口桂乃, 安藤英紀, 田島健次, 長澤一樹, 清水太郎, 異島優, 松島得雄, 草野貴友, 石田竜弘

セルロース学会年次大会講演要旨集, 29th, 2022
Biological role and application of serum albumin-derived supersulfides

Ishima Yu

93(5) 628-636, Oct 25, 2021
Development of Dual Cell Targeting Redox-Sensitive Nano-Radical Scavenger and its therapeutic potential against hepatitis

安田健吾, 木下遼, 前田仁志, 皆吉勇紀, 櫻木美菜, 水田夕稀, 山崎啓之, 異島優, 石田竜弘, 渡邊博志 …

日本薬剤学会年会講演要旨集(CD-ROM), 36th, 2021
アルブミンを用いたエダラボンナノDDS戦略の構築と肝疾患治療への応用

安田健吾, 木下遼, 前田仁志, 皆吉勇紀, 櫻木美菜, 山崎啓之, 水田夕稀, 異島優, 石田竜弘, 渡邊博志 …

人工血液, 29(1), 2021
肝マクロファージを標的としたレドックス応答性ナノラジカルスカベンジャーの開発と肝疾患治療への応用

安田健吾, 木下遼, 前田仁志, 皆吉勇紀, 櫻木美菜, 山崎啓之, 水田夕稀, 異島優, 石田竜弘, 渡邊博志 …

日本薬学会九州支部大会講演要旨集, 38th, 2021
Evaluation of functions of HepG2 cells cultured by three-dimensional culture system using nano-fibrillated bacterial cellulose (NFBC)

赤木俊介, 安藤英紀, 田島健次, 松島得雄, 草野貴友, 清水太郎, 異島優, 石田竜弘

セルロース学会年次大会講演要旨集, 28th, 2021
Studies for development of three-dimensional culture system using nano-fibrillated bacterial cellulose (NFBC)

安藤英紀, 赤木俊介, 田島健次, 清水太郎, 異島優, 松島得雄, 草野貴友, 石田竜弘

セルロース学会年次大会講演要旨集, 28th, 2021
Thioredoxin-albumin fusion protein prevents urban aerosol-induced lung injury

田中健一郎, 久保田真帆, 下田実可子, 池田真由美, 異島優, 川原正博

Biomedical Research on Trace Elements (Web), 32(2) 2-P2-28, 2021
Development of novel PTX formulations using hydrophilic or amphiphilic nanofibrillated bacterial cellulose and evaluation of their therapeutic efficacy on peritoneally disseminated gastric cancer

赤木俊介, 安藤英紀, 田島健次, 松島得雄, 草野貴友, 清水太郎, 異島優, 石田竜弘

日本薬剤学会年会講演要旨集(CD-ROM), 36th, 2021

Books and Other Publications

S-Nitroso Adducts of Albumin Analogs: Characterization, Categorization, and Possible Future Therapeutic Applications

Ishima Yu, Ulrich Kragh-Hansen, Masaki Otagiri

Nov 11, 2016

Presentations

286

アルブミンを基盤とした臓器特異的移行性を有するDDSキャリアの作製

橋本愛子, 異島優, 安藤英紀, 石田竜弘

第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct 28, 2023
Investigation of the usefulness of human serum albumin nanoparticles as antigen delivery carriers to the spleen

Yamade Rina, Shimizu Taro, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

日本薬剤学会第2回英語セミナー, Feb 2, 2023
Accelerated blood clearance of PEGylated liposomal antitumor agents after topical application of PEG derivatives containing cosmetics in a mouse model

Gaballa S A, Shimizu Taro, ANDO Hidenori, Ishima Yu, Emam Abdallah Emam Sherif, Ibrahim M, Mady F M, Naguib Y W, Khaled K A, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Transfusion of mouse B cells, embedded antigens with hydroxyl PEG-modified liposomes in vitro, induces cellular immune responses in mice

Kawaguchi Yoshino, Shimizu Taro, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Oral sodium bicarbonate enhances accumulation and antitumor effects of PEGylated liposomal doxorubicin (Doxil®)

Matsuo Nana, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Preparation, optimization, and evaluation of anionic DPPG-based LNPs for delivery of peptide antigens

Abdelhameed Mostafa Ramadan Eslam, ANDO Hidenori, Yamamoto Haruka, Fukumoto Mako, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
The mechanism investigation of intestinal absorption enhancement of drugs using ionic liquids

Fukuda Shoichiro, ANDO Hidenori, Maruyama Atsuya, Nakae Takashi, Tatsumi Noboru, Hamamoto Hidetoshi, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Neutralization of acidic tumor microenvironment by dosing of sodium potassium citrate (K/Na citrate) enhances antitumor effects of Abraxane®

Uehara Riku, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Differential organ-specific distribution of human serum albumin denatured by various modifications

Hashimoto Aiko, Ishima Yu, ANDO Hidenori, Shimizu Taro, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
An ionic liquids-based topical antitumor vaccine: a mechanism for induction of antitumor immunity via topical application of cancer-antigen peptides

Matsuzaki Takaaki, Shimizu Taro, ANDO Hidenori, Ishima Yu, Yamanaka K, Hamamoto H, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Development of a novel technique for antibody induction against membrane proteins by spleen immunization with membrane protein-loaded PEG-modified liposomes

Yamamoto Shunto, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
Induction of neutralizing antibodies by immunization with inactivated human TNF-alpha in mice

Yamamoto Haruka, ANDO Hidenori, Yasukazu Omoto, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

15th International Symposium on Nanomedicine, Dec 7, 2022
不活化ヒト TNFα 誘導体のマウスへの免疫による中和抗体の誘導評価

Yamamoto Haruka, ANDO Hidenori, 大本安一, Kawaguchi Yoshino, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

第1回日本抗体学会設立記念学術大会, Nov 26, 2022
白金製剤と血漿タンパク質との相互作用:時間依存性に関する検討

Matsuo Nana, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

日本薬物動態学会第37回年会, Nov 8, 2022
Humira®(adalimumab)投与時の抗薬物抗体(ADA)誘導に関する検討:マウス型抗ヒトTNFαモノクローナル抗体をマウスに投与した際のADA誘導

Yamamoto Haruka, ANDO Hidenori, 大本安一, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov 5, 2022
全身性エリテマトーデスモデルマウス由来B細胞の取り込み能についての検討

Mizumachi Kenta, Shimizu Taro, Ueda Hiro, Takata Haruka, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov 5, 2022
Biological roles of supersulfide in human hair

Hirai Takeru, Tasaka Nanami, ANDO Hidenori, Shimizu Taro, Ishida Tatsuhiro, Ishima Yu

Redox Week in Sendai 2022, Oct 29, 2022
デキサメタゾンが及ぼすPEG修飾ナノ粒子による抗PEG抗体誘導への影響

Takata Haruka, Shimizu Taro, Abe Shunji, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

第16回次世代を担う若手医療薬科学シンポジウム, Oct 29, 2022
PEG修飾リポソームの投与経路がおよぼす抗PEG抗体誘導への影響に関する検討

Takata Haruka, Shimizu Taro, ANDO Hidenori, Ishima Yu, Ishida Tatsuhiro

第43回生体膜と薬物の相互作用シンポジウム, Oct 6, 2022
膜タンパク質搭載PEG修飾リポソームの脾臓送達による抗膜タンパク質抗体誘導

Yamamoto Shunto, ANDO Hidenori, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro

第43回生体膜と薬物の相互作用シンポジウム, Oct 6, 2022

Teaching Experience

Apr, 2024 - Present

Pharmaceutical Technology (Kyoto Pharmaceutical University)
Sep, 2023 - Present

薬学総合演習
Sep, 2023 - Present

Biopharmaceutics (Kyoto Pharmaceutical University)
Apr, 2023 - Present

Design for pharmaceutical drugs (Kyoto Pharmaceutical University)
Apr, 2023 - Present

Introduction to DDS (Kyoto Pharmaceutical University)
- Present

Practice of Pharmacology (Kumamoto University, Tokushima University)
Seminar of Drug Development (Tokushima University)
How to create academic papers (Tokushima University)
Special Lecture for Clinical Pharmacokinetics (Tokushima University)
Core DDS lecture (Tokushima University)
Pharmaceutics (Kumamoto University, Tokushima University)
Graduate School, Course Open Seminer (Tokushima University)
Master's Thesis Research in Pharmaceutical Sciences (Tokushima University)
Research Training in Pharmaceutical Sciences I (Tokushima University)

Professional Memberships

Research Projects

各アルブミン相互作用タンパク質の特性を活用した革新的アルブミンDDSキャリアの開発

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2024 - Mar, 2027

異島優
Development of intranasal vaccine using albumin-based nanoparticles

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2024 - Mar, 2026
Establishment of supersulfur molecule in-cell chemistry and its application to life science research

Grants-in-Aid for Scientific Research Grant-in-Aid for Transformative Research Areas (A), Grant-in-Aid for Transformative Research Areas (A), Japan Society for the Promotion of Science, Sep, 2021 - Mar, 2026
植物ポリマーを利用した多機能バイオ化成品製造エコリファイナリーシステムの開発

科学研究費助成事業基盤研究(A), 基盤研究(A), 日本学術振興会, Apr, 2022 - Mar, 2025

浅田元子, 異島優, 山田久嗣, 櫻庭春彦
脳腫瘍移行性の高い免疫細胞の探索と免疫細胞への薬物搭載による脳腫瘍治療法の開発

科学研究費助成事業挑戦的研究(萌芽), 挑戦的研究(萌芽), 日本学術振興会, Jun, 2022 - Mar, 2024

清水太郎, 石田竜弘, 異島優
Development of albumin DDS carrier based on an understanding of the endogenous albumin transport system

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Development of onset prediction markers that contribute to preventive medical science

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2023

ISHIMA Yu
Development of albumin-binding nitric oxide donors for treatment of pancreatic cancer

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023

Nishi Koji
Enhanced absorption drug delivery system by ionic liquid

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

ISHIDA Tatsuhiro
Development of novel multifunctional nanoparticles based on uptake mechanism of endogenous albumin by pancreatic cancer cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

ISHIMA Yu
Development of transdermal drug delivery system by ionic liquid

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2018 - Mar, 2020

ISHIDA Tatsuhiro
Development of reproductive technology against aging-related infertility

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Takeo Toru
Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Negishi Yoichi, SUZUKI RYO, NOMIZU MOTOYOSHI, TAKAHASHI YOKO, MARUYAMA TORU, ISHIMA YU, SAWADA HONOKA, SASAYAMA MIZUKI
Study of immunological response to nucleic acid delivery system

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

ISHIDA Tatsuhiro
Development of renal delivery system for hybridized tissue regenerating factors and its application for kidney disease

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

MARUYAMA TORU
Development of transport system of NO and H2S based on Human serum albumin

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

ISHIMA Yu, MARUYAMA Toru
新規ケラチン酸化定量系を用いた美髪と美肌作用を有するミツバチ産品の網羅的解析

研究助成金, 山田養蜂場みつばち研究助成基金, Apr, 2017 - Mar, 2018

異島優
難治性のがん微小環境制御能を搭載したアルブミンナノ粒子の開発

研究助成金, 武田科学振興財団, Apr, 2017 - Mar, 2018

異島優
高分子抗癌剤の腫瘍移行性を高める腫瘍内微環境制御剤SNO-HSA-Dimerの開発

大内典明・惠子医療基金, 大阪コミュニティー財団, Apr, 2017 - Mar, 2018

異島優
Development of novel hybrid anti-oxidant based on albumin fusion technology and its therapeutic application on acute radiation syndrome

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

OTAGIRI Masaki

Industrial Property Rights

WO2019-225296 薬物送達用担体

丸山徹, 渡邊博志, 異島優, 前田仁志, 水田夕稀, 木下遼
WO2017-209028 美白化粧料、及びそれに含まれるアルブミン系化合物の製造方法

丸山徹, 池田真由美, 異島優, 水田夕稀
特開2017-186315 α1−酸性糖タンパク質の血中濃度の上昇をメカニズムとした慢性腎臓病治療薬

丸山徹, 渡邊博志, 異島優, 藤村留衣, 小田切優樹
特許第6094485号ビリルビン排泄促進剤

小田切優樹, 丸山徹, 異島優, 蓑毛藍
特許第5961957号抗癌剤

小田切優樹, 異島優, 渡邊博志, 丸山徹
特許第5842367号抗癌剤増感剤

渡邊博志, 異島優, 丸山徹, 小田切優樹
特許第5803267号 S−ニトロソ化α1−酸性糖タンパク質を含有する抗菌剤

渡辺佳織, 渡邊博志, 異島優, 丸山徹, 小田切優樹
特許第5724937号腎臓集積性を示すペプチド、製剤

渡邊博志, 國安明彦, 異島優, 小田切優樹, 丸山徹
特許第5673596号細胞膜透過性を有する製剤及び細胞膜透過性組成物

渡邊博志, 國安明彦, 異島優, 小田切優樹, 丸山徹
特開2013-224282 細胞膜透過性を有する製剤、細胞膜透過性組成物及び薬物輸送方法

渡邊博志, 國安明彦, 異島優, 小田切優樹, 丸山徹
特開2013-224283 腎臓集積性を示すペプチド、薬物担体、製剤、医薬組成物

渡邊博志, 國安明彦, 異島優, 小田切優樹, 丸山徹
特開2013-067591 抗癌剤

小田切優樹, 異島優, 渡邊博志, 丸山徹
WO2013-022058 ビリルビン排泄促進剤

小田切優樹, 丸山徹, 異島優, 蓑毛藍
特許第4935242号脂肪酸を含有するS-ニトロソタンパク質とその製法

異島優, 赤池孝章, 小田切優樹
特開2010-172277 高リガンド親和性アルブミン変異体の製造方法

蓑毛藍, 異島優, 丸山徹, 森岡弘志, 小田切優樹

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