Yukihiko Hirai

J-GLOBAL         Last updated: Oct 9, 2019 at 15:32
 
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Name
Yukihiko Hirai
E-mail
hirainms.ac.jp
Affiliation
Nippon Medical School

Research Areas

 
 

Published Papers

 
Highly efficient ultracentrifugation-free chromatographic purification of recombinant AAV serotype 9 (rAAV9)
Taro Tomono, Yukihiko Hirai, Hironori Okada, Yoshitaka Miyagawa, Kumi Adachi, Shuhei Sakamoto, Yasuhiro Kawano, Hideto Chono, Junichi Mineno, Akiko Ishii, Takashi Shimada, Masafumi Onodera, Akira Tamaoka, Takashi Okada
Molecular Therapy Methods &Clinical Development   11 180-190   Dec 2018   [Refereed]
Tsutomu Igarashi, Koichi Miyake,Maika Kobayashi, Shuhei Kameya,Chiaki Fujimoto,Kenji Nakamoto, Hisatomo Takahashi, Toru Igarashi, Noriko Miyake, Osamu Iijima,Yukihiko Hirai, Takashi Shimada, Takashi Okada, Hiroshi Takahashi
Molecular Vision   22 816-826   Jul 2016   [Refereed]
Tomono T, Hirai Y, Okada H, Adachi K, Ishii A, Shimada T, Onodera M, Tamaoka A, Okada T
Molecular therapy. Methods & clinical development   3 15058   2016   [Refereed]
Nakamura-Takahashi A, Miyake K, Watanabe A, Hirai Y, Iijima O, Miyake N, Adachi K, Nitahara-Kasahara Y, Kinoshita H, Noguchi T, Abe S, Narisawa S, Millán JL, Shimada T, Okada T
Molecular therapy. Methods & clinical development   3 15059   2016   [Refereed]
Hironaka K, Yamazaki Y, Hirai Y, Yamamoto M, Miyake N, Miyake K, Okada T, Morita A, Shimada T
Scientific reports   5 13104   Aug 2015   [Refereed]
Yamazaki Y, Hirai Y, Miyake K, Shimada T
Scientific reports   4 5506   Jul 2014   [Refereed]
Hirai T, Enomoto M, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M, Kuwahara H, Yamamoto M, Tajiri M, Miyata H, Hirai Y, Tominaga M, Shinomiya K, Mizusawa H, Okawa A, Yokota T
Molecular therapy : the journal of the American Society of Gene Therapy   22(2) 409-419   Feb 2014   [Refereed]
Machida A, Kuwahara H, Mayra A, Kubodera T, Hirai T, Sunaga F, Tajiri M, Hirai Y, Shimada T, Mizusawa H, Yokota T
Molecular pain   9 36   Jul 2013   [Refereed]
Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, Hirai Y, Sotome S, Mizusawa H, Shinomiya K, Okawa A, Yokota T
Human gene therapy methods   23(2) 119-127   Apr 2012   [Refereed]
Uchida A, Sasaguri H, Kimura N, Tajiri M, Ohkubo T, Ono F, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Yamamoto M, Yokota S, Kubodera T, Tomori M, Sakaki K, Enomoto M, Hirai Y, Kumagai J, Yasutomi Y, Mochizuki H, Kuwabara S, Uchihara T, Mizusawa H, Yokota T
Brain : a journal of neurology   135(Pt 3) 833-846   Mar 2012   [Refereed]
Miyake K, Miyake N, Yamazaki Y, Shimada T, Hirai Y
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   79(6) 394-402   2012   [Refereed]
Nihira T, Yasuda T, Hirai Y, Shimada T, Mizuno Y, Mochizuki H
Journal of neuroscience methods   201(1) 55-60   Sep 2011   [Refereed]
Isotani M, Miyake K, Miyake N, Hirai Y, Shimada T
Cancer investigation   29(5) 353-359   Jun 2011   [Refereed]
Miyake N, Miyake K, Yamamoto M, Hirai Y, Shimada T
Brain research   1389 19-26   May 2011   [Refereed]
Mayra A, Tomimitsu H, Kubodera T, Kobayashi M, Piao W, Sunaga F, Hirai Y, Shimada T, Mizusawa H, Yokota T
Biochemical and biophysical research communications   405(2) 204-209   Feb 2011   [Refereed]
Kubodera T, Yamada H, Anzai M, Ohira S, Yokota S, Hirai Y, Mochizuki H, Shimada T, Mitani T, Mizusawa H, Yokota T
Human gene therapy   22(1) 27-34   Jan 2011   [Refereed]
Ogawa K, Hirai Y, Ishizaki M, Takahashi H, Hanawa H, Fukunaga Y, Shimada T
Molecular genetics and metabolism   96(3) 91-96   Mar 2009   [Refereed]
Tahara I, Miyake K, Hanawa H, Kurai T, Hirai Y, Ishizaki M, Uchida E, Tajiri T, Shimada T
Molecular therapy : the journal of the American Society of Gene Therapy   15(10) 1805-1811   Oct 2007   [Refereed]
WATANABE Atsushi, ASANO Arisa, MIYAKE Hidehiko, MIGITA Makoto, HIRAI Yukihiko, SHIMURA Toshiro, SHIMADA Takashi
医学教育   38(4) 245-250   Aug 2007
Kurai T, Hisayasu S, Kitagawa R, Migita M, Suzuki H, Hirai Y, Shimada T
Molecular therapy : the journal of the American Society of Gene Therapy   15(1) 38-43   Jan 2007   [Refereed]

Misc

 
平井幸彦
日本医科大学ハイテクリサーチセンター研究報告 平成10年4月-平成15年3月   23-25   2003
渡辺淳, 平井幸彦, 島田隆, 浅野ありさ
J Nippon Med Sch   69(6) 672   Dec 2002
平井幸彦
日本医科大学ハイテクリサーチセンター研究報告 平成10年4月-平成15年3月   26-28   2003

Conference Activities & Talks

 
三宅弘一, 藤倉輝道, 渡邉淳, 平井幸彦, 山崎吉之, 飯島修, 三宅紀子, 山本基子, 竹下俊行, 島田隆
医学教育   4 Jul 2012   
渡辺淳, 平井幸彦, 飯島修, 山崎吉之, 三宅紀子, 山本基子, 佐々木元子, 島田隆, 三宅弘一
日本遺伝カウンセリング学会誌   10 May 2012   
比企能人, 佐々木敬, 根本昌実, 根元昌実, 大橋十也, 平井幸彦, 田嶼尚子
糖尿病   25 Apr 2009   
比企能人, 佐々木敬, 根本昌実, 大橋十也, 平井幸彦, 田嶼尚子
再生医療   5 Feb 2009   
比企能人, 佐々木敬, 中井望, 藤本啓, 根本昌実, 大橋十也, 羽野寛, 衞藤義勝, 平井幸彦, 島田隆, 田嶼尚子
東京慈恵会医科大学雑誌   15 Nov 2008   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2003 - 2005    Investigator(s): Yoshuhiko SEINO
Fabry disease is an inherited lysosomal storage disorder characterized by a pathological intracellular glycosphingolipid deposition. The disease is caused by a deficit in the lysosomal enzyme α-galatosidase A, the gene for which is located in the ...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2002 - 2004    Investigator(s): Takashi SHIMADA
1.Gene therapy : We examined the utility of recently identified sulfatase activating enzyme (FGE) for expression of arylsulfatase A(ASA) in gene therapy of metachromatic leukodustrophy(MLD). Our data demonstrated that FGE co-expression is essentia...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Yukihiko HIRAI
Only recombinant adeno-associated virus (Raav) system may have the character for site specific integration into AAVS1 site on human chromosome 19q13.3-qter. Site-specific integration mechanism starts with the complex formation mediated by viral en...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1996 - 1997    Investigator(s): Yukihiko HIRAI
None of currently available gene transfer system has possessed the property of site-specific integration of interested genes to the preferred site on the host genome. Only recombinant adeno-associated virus (rAAV) is potentially possible to have t...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1993 - 1995    Investigator(s): Yukihiko HIRAI
For establishment of in vitro packaging system, recombinant-adeno-associated virus (r-AAV) producing HeLa cell lines were established by cotransfection of packaging plasmid (psub201) and vector plasmid, (pNAV/AAV ; neoR driven by HSV-TK promoter)....