2019年7月2日
Cyclic Naphthalene Diimide Dimer with a Strengthened Ability to Stabilize Dimeric G-Quadruplex.
Chemistry (Weinheim an der Bergstrasse, Germany)
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- 巻
- 25
- 号
- 37
- 開始ページ
- 8691
- 終了ページ
- 8695
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1002/chem.201901468
A new type of dimeric cyclic naphthalene diimide derivatives (cNDI-dimers) carrying varied linker length were designed and synthesized to recognize dimeric G-quadruplex structures. All of the cNDI-dimers exhibited a high preference for recognizing G-quadruplex structures, and significantly enhanced the thermal stability of the dimeric G-quadruplex structure over the cNDI monomer by increasing the melting temperature by more than 23 °C, which indicated the strengthened ability of cNDI dimers for stabilizing dimeric G-quadruplex. cNDI dimers also showed a stronger ability to inhibit telomerase activity and stop telomere DNA elongation than cNDI monomer, which showed an improved anticancer potentiality for further therapeutic application.
- ID情報
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- DOI : 10.1002/chem.201901468
- PubMed ID : 31069868