Ikuko Yamada

Profile Information

Affiliation: Technical Scientist, Mouse Phenotype Analysis Division, RIKEN BioResource Research Center

Degree: 博士（行動科学）(筑波大学)

J-GLOBAL ID: 201901013032248055
researchmap Member ID: B000367177

External link: https://nrid.nii.ac.jp/ja/nrid/1000060568723/

遺伝子変異マウスの行動解析を行っています。

Research Interests

Research Areas

Research History

Apr, 2009 - Present

Technical Scientist, Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Research Center

Awards

Aug, 2003

上武学術奨励賞, 新生仔期および成体期5,7-dihydroxytryptamine処置ラットの高架式十字迷路における”不安”行動, 筑波大学心理学系

山田郁子

Papers

Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences

Mamiko Yamada, Yohei Nitta, Tomoko Uehara, Hisato Suzuki, Fuyuki Miya, Toshiki Takenouchi, Masaru Tamura, Shinya Ayabe, Atsushi Yoshiki, Akiteru Maeno …

European Journal of Medical Genetics, 104804-104804, Jun, 2023
Deficiency of protocadherin 9 leads to reduction in positive emotional behaviour.

Masato Uemura, Tamio Furuse, Ikuko Yamada, Tomoko Kushida, Takaya Abe, Keiko Imai, Soichi Nagao, Moeko Kudoh, Katsuhiko Yoshizawa, Masaru Tamura …

Scientific reports, 12(1) 11933-11933, Jul 13, 2022
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.

Tetsuya Hirata, Atsushi Kobayashi, Tamio Furuse, Ikuko Yamada, Masaru Tamura, Hiroyuki Tomita, Yuko Tokoro, Akinori Ninomiya, Yoshitaka Fujihara, Masahito Ikawa …

The Journal of biological chemistry, 101720-101720, Feb 10, 2022
Role of Scl39a13/ZIP13 in cardiovascular homeostasis.

Takafumi Hara, Ikuko Yamada, Takuto Ohashi, Masaru Tamura, Atsushi Hijikata, Takashi Watanabe, Minghao Gao, Kana Ito, Saeko Kawamata, Shiori Azuma …

PloS one, 17(10) e0276452, 2022
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.

Kensuke Matsumura, Kaoru Seiriki, Shota Okada, Masashi Nagase, Shinya Ayabe, Ikuko Yamada, Tamio Furuse, Hirotoshi Shibuya, Yuka Yasuda, Hidenaga Yamamori …

Nature communications, 11(1) 859-859, Feb 26, 2020 Peer-reviewed
A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain.

Furuse T, Mizuma H, Hirose Y, Kushida T, Yamada I, Miura I, Masuya H, Funato H, Yanagisawa M, Onoe H …

Disease models & mechanisms, 12(9), Sep, 2019 Peer-reviewed
Autophosphorylation of F-actin binding domain of CaMKIIβ is required for fear learning.

Karam Kim, Akio Suzuki, Hiroto Kojima, Meiko Kawamura, Ken Miya, Manabu Abe, Ikuko Yamada, Tamio Furuse, Shigenaru Wakana, Kenji Sakimura …

Neurobiology of learning and memory, 157 86-95, Jan, 2019 Peer-reviewed
Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Jan Rozman, Birgit Rathkolb, Manuela A. Oestereicher, Christine Schütt, Aakash Chavan Ravindranath, Stefanie Leuchtenberger, Sapna Sharma, Martin Kistler, Monja Willershäuser, Robert Brommage …

Nature Communications, 9(1), Dec 1, 2018 Peer-reviewed
Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions

Tadahiro Shimazu, Tamio Furuse, Shabeesh Balan, Ikuko Yamada, Shuzo Okuno, Hiroko Iwanari, Takehiro Suzuki, Takao Hamakubo, Naoshi Dohmae, Takeo Yoshikawa …

Scientific Reports, 8(1) 1179, Dec 1, 2018 Peer-reviewed
CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene

Michiko Hirose, Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Yuki Hatanaka, Kimiko Inoue, Tatsuhiko Goto, Hideki Kaneda, Ikuko Yamada, Tamio Furuse …

SCIENTIFIC REPORTS, 7 42476, Feb, 2017 Peer-reviewed
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny.

Furuse T, Miyake K, Kohda T, Kaneda H, Hirasawa T, Yamada I, Kushida T, Kashimura M, Kobayashi K, Ishino F …

Genes & nutrition, 12 1, Jan 19, 2017 Peer-reviewed
Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino …

GENES AND NUTRITION, 12, Jan, 2017 Peer-reviewed
Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians

Masahito Irie, Masanobu Yoshikawa, Ryuichi Ono, Hirotaka Iwafune, Tamio Furuse, Ikuko Yamada, Shigeharu Wakana, Yui Yamashita, Takaya Abe, Fumitoshi Ishino …

PLOS GENETICS, 11(9) e1005521, Sep, 2015 Peer-reviewed
Sirh7/Ldoc1 knockout mice exhibit placental P4 overproduction and delayed parturition

Mie Naruse, Ryuichi Ono, Masahito Irie, Kenji Nakamura, Tamio Furuse, Toshiaki Hino, Kanako Oda, Misho Kashimura, Ikuko Yamada, Shigeharu Wakana …

DEVELOPMENT, 141(24) 4763-4771, Dec, 2014 Peer-reviewed
Advance of the linkage analysis using genetically closed inbred mouse strains based on the high-throughput mapping system among C57BL/6 substrains

Ikuo Miura, Akiko Shinogi, Daiki Usuda, Tamio Furuse, Ikuko Yamada, Kimio Kobayashi, Tomohiro Suzuki, Hideki Kaneda, Masaru Tamura, Hiroshi Masuya …

GENES & GENETIC SYSTEMS, 88(6) 370-370, Dec, 2013 Peer-reviewed
Pheno-Pub: a total support system for the publication of mouse phenotypic data on the web

Tomohiro Suzuki, Tamio Furuse, Ikuko Yamada, Hiromi Motegi, Yasuyo Kozawa, Hiroshi Masuya, Shigeharu Wakana

MAMMALIAN GENOME, 24(11-12) 473-483, Dec, 2013 Peer-reviewed
Behavioral and neuromorphological characterization of a novel Tuba1 mutant mouse

Tamio Furuse, Ikuko Yamada, Tomoko Kushida, Hiroshi Masuya, Ikuo Miura, Hideki Kaneda, Kimio Kobayashi, Yumiko Wada, Shigeki Yuasa, Shigeharu Wakana

BEHAVIOURAL BRAIN RESEARCH, 227(1) 167-174, Feb, 2012 Peer-reviewed
Direct comparison of behavioral-phenotype data among Japan mouse clinic and IMPC phenotyping centers

Tamio Furuse, Ikuko Yamada, Tomoko Kushida, Tomohiro Suzuki, Nobuhiko Tanaka, Hiroshi Masuya, Shigeharu Wakana

NEUROSCIENCE RESEARCH, 71 E390-E390, 2011 Peer-reviewed
ENU Mutagenesis Screening for Dominant Behavioral Mutations Based on Normal Control Data Obtained in Home-Cage Activity, Open-Field, and Passive Avoidance Tests

Yumiko Wada, Tamio Furuse, Ikuko Yamada, Hiroshi Masuya, Tomoko Kushida, Yoko Shibukawa, Yuji Nakai, Kimio Kobayashi, Hideki Kaneda, Yoichi Gondo …

EXPERIMENTAL ANIMALS, 59(4) 495-510, Jul, 2010 Peer-reviewed
SDOP-DB: a comparative standardized-protocol database for mouse phenotypic analyses.

Tanaka N, Waki K, Kaneda H, Suzuki T, Yamada I, Furuse T, Kobayashi K, Motegi H, Toki H, Inoue M …

Bioinformatics (Oxford, England), 26(8) 1133-1134, Apr 15, 2010 Peer-reviewed

Misc.

大規模マウス表現型データの統合的解析手法の開発

田中信彦, 茂木浩未, 鈴木智広, 金田秀貴, 三浦郁夫, 山田郁子, 古瀬民生, 小林喜美男, 土岐秀明, 井上麻紀 …

第26回モロシヌス研究会, Jun, 2012
Toward the development of information systems to enhance utility of data from the international mouse phenotyping project

TANAKA Nobuhiko, MOTEGI Hiromi, SUZUKI Tomohiro, YAMADA Ikuko, FURUSE Tamio, INOUE Maki, MINOWA Osamu, NODA Tetsuo, WAKANA Shigeharu, MASUYA Hiroshi

日本分子生物学会年会プログラム・要旨集(Web), 34th 2P-0239 (WEB ONLY), 2011
SDOP-DB: a database for international sharing and standardization of mouse phenotyping protocols

TANAKA Nobuhiko, WAKI Kazunori, KANEDA Hideki, SUZUKI Tomohiro, YAMADA Ikuko, FURUSE Tamio, KOBAYASHI Kimio, MOTEGI Hiromi, TOKI Hideaki, MINOWA Osamu …

生化学, 83回・33回 4P-1203, Dec, 2010
ENUミュータジェネシスにより作出された高活動変化マウスの表現型解析(Phenotypic analyses of an ENU mutant mouse which exhibits hyperlocomotor activity)

古瀬民生, 和田由美子, 山田郁子, 串田知子, 三浦郁生, 小林喜美男, 金田秀貴, 桝屋啓志, 湯浅茂樹, 若菜茂晴

神経化学, 49(2-3) 591-591, Aug, 2010
RIKEN BRC Japan Mouse Clinic III: Release of Phenotyping Data on Web-Based Database "Pheno-Pub" in JMC

SUZUKI Tomohiro, FURUSE Tamio, NISHIMURA Shizuka, KANEDA Hideki, KOBAYASHI Kimio, MIURA Ikuo, YAMADA Ikuko, MINOWA Osamu, TOKI Hideaki, MOTEGI Hiromi …

Exp Anim, 59(3 Supplement) 336, May, 2010
RIKEN BRC Japan Mouse Clinic II: Behavioral analysis of MSM, Japanese wild-derived mouse strain

YAMADA Ikuko, FURUSE Tamio, KUSHIDA Tomoko, SUZUKI Tomohiro, MASUYA Hiroshi, KANEDA Hideki, KOBAYASHI Kimio, MIURA Ikuo, MORIWAKI Kazuo, YAMAMURA Ken‐ichi …

Exp Anim, 59(3 Supplement) 336, May, 2010
Toward international standardisation and sharing of mouse phenotyping protocols

TANAKA Nobuhiko, WAKI Kazunori, KANEDA Hideki, SUZUKI Tomohiro, YAMADA Ikuko, FURUSE Tamio, KOBAYASHI Kimio, MOTEGI Hiromi, TOKI Hideaki, INOUE Maki …

Exp Anim, 59(3 Supplement) 293, May, 2010
RIKEN BRC Japan Mouse Clinic I: Progress and Future Plan

SUZUKI Tomohiro, KOBAYASHI Kimio, KANEDA Hideki, MIURA Ikuo, FURUSE Tamio, YAMADA Ikuko, MINOWA Osamu, TOKI Hideaki, MOTEGI Hiromi, INOUE Maki …

Exp Anim, 59(3 Supplement) 335, May, 2010
Establishment and practical application of high-speed gene profiling system for whole genome scan in the mouse

MIURA Ikuo, SHINOGI Akiko, MORITA Chiharu, SUZUKI Tomohiro, KANEDA Hideki, FURUSE Tamio, KOBAYASHI Kimio, YAMADA Ikuko, MEKADA Kazuyuki, NAKATA Hatsumi …

Exp Anim, 59(3 Supplement) 293, May, 2010
SDOPDB：マウス表現型解析プロトコル比較検討データベース

田中信彦, 脇和規, 金田秀貴, 鈴木智広, 山田郁子, 古瀬民生, 小林喜美男, 茂木浩未, 土岐秀明, 井上麻紀 …

第2回ASI-BRC連携フォーラム, Nov, 2009
RIKEN BRC Japan Mouse Clinic III: Behavioral pipeline and the analysis of standard mouse strains

YAMADA Ikuko, SHIBUKAWA Yoko, KUSHIDA Tomoko, SUZUKI Tomohiro, MASUYA Hiroshi, KANEDA Hideki, KOBAYASHI Kimio, MIURA Ikuo, FURUSE Tamio, WAKANA Shigeharu

Exp Anim, 58(3 Supplement) 273, Apr, 2009
RIKEN BRC Japan Mouse Clinic I: Overview

KOBAYASHI Kimio, SUZUKI Tomohiro, KANEDA Hideki, MIURA Ikuo, HURUSE Tamio, YAMADA Ikuko, MOTEGI Hiromi, TOKI Hideaki, INOUE Maki, MINOWA Osamu …

Exp Anim, 58(3 Supplement) 272, Apr, 2009
Infrastructures of mouse phenotype DB (1): Technology development for the international sharing of phenotyping procedures

TANAKA Nobuhiko, WAKI Kazunori, KANEDA Hideki, SUZUKI Tomohiro, YAMADA Ikuko, FURUSE Tamio, KOBAYASHI Mikio, MOTEGI Hiromi, TOKI Hideaki, INOUE Maki …

Exp Anim, 58(3 Supplement) 274, Apr, 2009
Development of the ontology-based data processing system of experimental analysis and protocol for international integration of mouse phenome information.

WAKI Kazunori, TANAKA Nobuhiko, KANEDA Hideki, SUZUKI Tomohiro, YAMADA Ikuko, FURUSE Tamio, KOBAYASHI Kimio, MOTEGI Hiromi, TOKI Hideaki, INOUE Maki …

日本分子生物学会年会講演要旨集, 32nd(Vol.3) 54, 2009
RIKEN BRC JAPAN MOUSE CLINIC I: ANALYSIS OF STANDARD MOUSE STRAINS ON FUNDAMENTAL PIPELINE AND DATA CAPTURING "PHENO-PUB" SYSTEM

SUZUKI Tomohiro, KANEDA Hideki, KOBAYASHI Kimio, MIURA Ikuo, FURUSE Tamio, YAMADA Ikuko, MINOWA Osamu, TOKI Hideaki, MOTEGI Hiromi, INOUE Maki …

日本分子生物学会年会講演要旨集, 32nd(Vol.3) 54, 2009
RIKEN BRC Japan Mouse Clinic II: Development of systems for the effective production and genotyping of mutant mouse strains

MIURA Ikuo, KANEDA Hideki, OGONUKI Narumi, OZAKI Ai, SUZUKI Chigusa, NAKAMURA Chika, SHINOGI Akiko, MORITA Chiharu, SUZUKI Tomohiro, KOBAYASHI Kimio …

日本分子生物学会年会講演要旨集, 32nd(Vol.3) 54, 2009
A plan of Japanese Mouse Clinic in RIKEN BRC

WAKANA Shigeharu, SUZUKI Tomohiro, MASUYA Hiroshi, MIURA Ikuo, KOBAYASHI Kimio, KANEDA Hideki, FURUSE Tamio, MOTEGI Hiromi, TOKI Hideaki, INOUE Maki …

Exp Anim, 57(3 Supplement) 203, Apr, 2008
Development of Intelligent Infrastructure for Experimental Protocols with Ontological Technology

TANAKA Nobuhiko, WAKI Kazunori, WAKANA Shigeharu, KOBAYASHI Norio, YAMADA Ikuko, FURUSE Tamio, TOYODA Tetsuro, MIZOGUCHI Riichiro, MASUYA Hiroshi

Proceedings of Annual Conference of the Japanese Society for Bioinformatics, 2008, 2008

Presentations

Analysis of activity and core body temperature of developmental disorder model mice using a telemetry system

Ikuko Yamada, Tomoko Kushida, Ikuo Miura, Tamio Furuse, Masaru Tamura

NPBPPP2020, Aug, 2020

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