2009年6月
Pilsicainide-Induced ST Segment Elevation and ST Segment Depression in Two Patients with Variant Forms of Brugada-Type Electrocardiographic Abnormalities
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
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- 巻
- 32
- 号
- 6
- 開始ページ
- 811
- 終了ページ
- 815
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1540-8159.2009.02371.x
- 出版者・発行元
- WILEY-BLACKWELL PUBLISHING, INC
In two patients with variant forms of Brugada electrocardiographic abnormalities, ST segment elevation, and reciprocal ST segment depression developed during intravenous administration of pilsicainide. In one patient, pilsicainide accentuated the ST segment elevation in leads I, aV(L), and V(1)-V(3) and caused ST segment depression in leads II, III, and aV(F). Coronary angiograms at the time of ST segment elevation were normal. In the other patient, pilsicainide accentuated the coved-type ST segment elevation in leads II, III, and aV(F) and caused ST segment depression in leads I, aV(L), and V(2)-V(5). Frequent premature ventricular complexes (PVCs) with two different left bundle branch block patterns developed during ST segment elevation. Intravenous isoproterenol returned the ST segment to baseline in both patients and suppressed the PVCs in the second patient. We hypothesize that a wide area of epicardial myocardium with large I(to) current might explain the reciprocal ST segment depression observed at the time of accentuated ST segment elevation.
(PACE 2009; 32:811-815).
(PACE 2009; 32:811-815).
- リンク情報
- ID情報
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- DOI : 10.1111/j.1540-8159.2009.02371.x
- ISSN : 0147-8389
- PubMed ID : 19545347
- Web of Science ID : WOS:000266465400020