2021年5月
Balenine, imidazole dipeptide, induces activation of superoxide dismutase in myotubes
FISHERIES SCIENCE
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- 巻
- 87
- 号
- 3
- 開始ページ
- 403
- 終了ページ
- 409
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12562-021-01516-7
- 出版者・発行元
- SPRINGER JAPAN KK
Balenine is one of the endogenous imidazole dipeptides. It is composed of beta-alanine and 3-methyl-l-histidine, which exist mainly in the muscles and the brain. The exact biological properties of balenine are still not well known, although the antioxidant activity of carnosine, another imidazole dipeptide, is known. In this study we investigated whether balenine exhibits antioxidant activity. It was found to decrease the superoxide anion (O-2(-)) and increased hydrogen peroxide (H2O2) generation. We found that SOD activity increased in balenine-treated C2C12 myotubes, although balenine did not increase expression of SOD mRNA. On the other hand, there were no changes in other antioxidant enzymes, CAT and GPX activity, and mRNA levels. In an in vitro assay, the direct activation of SOD treated by balenine was significantly higher than with carnosine treatment. Moreover, balenine constituent amino acids did not have the ability to activate SOD. Our results suggest that balenine contributes to antioxidant effects through activation of SOD.
- リンク情報
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- DOI
- https://doi.org/10.1007/s12562-021-01516-7
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000642821800001&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85104778019&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85104778019&origin=inward
- ID情報
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- DOI : 10.1007/s12562-021-01516-7
- ISSN : 0919-9268
- eISSN : 1444-2906
- SCOPUS ID : 85104778019
- Web of Science ID : WOS:000642821800001