2016年10月
SYNTHESIS OF PRODELPHINIDIN TRIMER ISOLATED FROM CISTUS ALBIDUS AND ITS GROWTH INHIBITORY ACTIVITY AGAINST HUMAN PROSTATE CANCER CELL LINES
HETEROCYCLES
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- 巻
- 92
- 号
- 10
- 開始ページ
- 1822
- 終了ページ
- 1831
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3987/COM-16-13557
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
First synthesis of prodelphinidin trimer (epigallocatechin-gallocatechin-catechin) isolated from Cistus albidus was accomplished from monomeric epigallocatechin electrophile and dimeric gallocatechin-catechin nucleophile. The condensation was worked using AgoTf as a Lewis acid and condensed product was successfully converted into titled compound in good yield. Synthesized compound showed significant growth inhibitory activity against human prostate PC-3 cell lines. Its activity was almost same as prodelphinidin B3.
- リンク情報
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- DOI
- https://doi.org/10.3987/COM-16-13557
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000388046400006&DestApp=WOS_CPL
- URL
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84992724476&origin=inward
- ID情報
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- DOI : 10.3987/COM-16-13557
- ISSN : 0385-5414
- eISSN : 1881-0942
- SCOPUS ID : 84992724476
- Web of Science ID : WOS:000388046400006