論文

2016年10月

SYNTHESIS OF PRODELPHINIDIN TRIMER ISOLATED FROM CISTUS ALBIDUS AND ITS GROWTH INHIBITORY ACTIVITY AGAINST HUMAN PROSTATE CANCER CELL LINES

HETEROCYCLES
  • Masataka Mori
  • ,
  • Kiriko Matsumoto
  • ,
  • Chisato Ishihara
  • ,
  • Koichiro Kawaguchi
  • ,
  • Sei-ichi Kawahara
  • ,
  • Yasunao Hattori
  • ,
  • Hiroshi Fujii
  • ,
  • Hidefumi Makabe

92
10
開始ページ
1822
終了ページ
1831
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3987/COM-16-13557
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

First synthesis of prodelphinidin trimer (epigallocatechin-gallocatechin-catechin) isolated from Cistus albidus was accomplished from monomeric epigallocatechin electrophile and dimeric gallocatechin-catechin nucleophile. The condensation was worked using AgoTf as a Lewis acid and condensed product was successfully converted into titled compound in good yield. Synthesized compound showed significant growth inhibitory activity against human prostate PC-3 cell lines. Its activity was almost same as prodelphinidin B3.

リンク情報
DOI
https://doi.org/10.3987/COM-16-13557
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000388046400006&DestApp=WOS_CPL
URL
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84992724476&origin=inward
ID情報
  • DOI : 10.3987/COM-16-13557
  • ISSN : 0385-5414
  • eISSN : 1881-0942
  • SCOPUS ID : 84992724476
  • Web of Science ID : WOS:000388046400006

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