2012年8月
Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver
CANCER SCIENCE
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- 巻
- 103
- 号
- 8
- 開始ページ
- 1445
- 終了ページ
- 1450
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1111/j.1349-7006.2012.02325.x
- 出版者・発行元
- WILEY-BLACKWELL
We investigated the process of induction of preneoplastic cells positive for glutathione S-transferase P-form (GST-P) in the rat liver. AAF (2-Acetylaminofluorene) mixed with normal rat chow at high concentration (0.04%) induced 517 000 +/- 86 000 GST-P+ single hepatocytes/g liver after 2 weeks followed by induction of a few foci and nodules after 46 weeks. Overproduction of GST-P+ single hepatocytes was dose- and time-dependent, and the induction kinetics were typical of first-order consecutive reaction, by which induction of the positive cells was nongenetic. Quantitative analysis indicated that the estimated numbers of cells in foci and nodules at 46 weeks after exposure to AAF ranged from 2.7 x 10(4) (214.7) to 3.6 x 10(6) (221.7) cells, and 2.0 x 10(4) (214.3) to 2.7 x 10(6) (221.4) cells, respectively, when analyzed by using two equations. According to the initiated cell theory of Farber, foci and nodules are formed through sequential cell division of 14 to 21-times or more within a short time period. The rapid growth exceeded the rate of cell division, indicating that the growth of preneoplastic cells is based on a nonclonal penetration mechanism. (Cancer Sci 2012; 103: 14451450)
- リンク情報
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- DOI
- https://doi.org/10.1111/j.1349-7006.2012.02325.x
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22568518
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659216
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000306901900011&DestApp=WOS_CPL
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864322169&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84864322169&origin=inward
- ID情報
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- DOI : 10.1111/j.1349-7006.2012.02325.x
- ISSN : 1347-9032
- eISSN : 1349-7006
- PubMed ID : 22568518
- PubMed Central 記事ID : PMC7659216
- SCOPUS ID : 84864322169
- Web of Science ID : WOS:000306901900011