論文

査読有り
2020年6月

Activation of EL-4 T-cells by irradiation with atmospheric oxygen plasma

JAPANESE JOURNAL OF APPLIED PHYSICS
  • Sitti Subaedah
  • ,
  • Haruka Uematsu
  • ,
  • Nobuya Hayashi

59
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.35848/1347-4065/ab83db
出版者・発行元
IOP PUBLISHING LTD

The activation of EL-4 T-cells is investigated when the T-cells are sensitized with monoclonal antibodies against CD3/CD28 followed by irradiation with atmospheric oxygen plasma. The proliferation of anti-CD3/CD28-sensitized EL-4 T-cells was evaluated as a function of the oxygen plasma irradiation duration. The plasma irradiation promotes cell proliferation: when plasma irradiation was applied to sensitize T-cells for 40 s, the cell number increased by five times over 24 h compared with that in a cell population that was not exposed to irradiation. Also, the plasma irradiation increases the production of interferon gamma in T-cells by a factor of two. Gene expression analysis of T-cell supports results of the proliferation and the immune function enhancements. (C) 2020 The Japan Society of Applied Physics


リンク情報
DOI
https://doi.org/10.35848/1347-4065/ab83db
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000546571700015&DestApp=WOS_CPL

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