Apr, 2019 - Mar, 2022
Mechanisms of lesion formation in Parkinson's disease: an analysis using tissue clearing and 3D observation
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C) Grant-in-Aid for Scientific Research (C)
- Grant number
- 19K07841
- Japan Grant Number (JGN)
- JP19K07841
- Authorship
- Principal investigator
- Grant amount
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- (Total)
- 4,290,000 Japanese Yen
- (Direct funding)
- 3,300,000 Japanese Yen
- (Indirect funding)
- 990,000 Japanese Yen
In the early and incidental cases of Parkinson's disease, alpha-synuclein accumulation was observed in various areas of the nervous system, including the brain and peripheral autonomic nervous system, suggesting that these may have occurred multicentrally. In progressive supranuclear palsy, the distribution/density of tau-positive structures were consistent with the manifesting clinical features. Furthermore, the distribution/laterality of tau-positive structures suggested the possibility of lesion extension along fiber connections. Tissue clearing and three-dimensional analysis enabled high-resolution imaging of tau-positive structures in progressive supranuclear palsy and provided important insights into the pathomechanism of lesion formation in this disease.
- Link information
- ID information
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- Grant number : 19K07841
- Japan Grant Number (JGN) : JP19K07841