Asako Murata

Profile Information

Affiliation: Associate professor, Kyushu University

Degree: Ph.D. (Life science)(Mar, 2006, The University of Tokyo)

Researcher number: 50557121
ORCID ID: https://orcid.org/0000-0003-2073-7272
J-GLOBAL ID: 201901010950382300
Researcher ID: E-9536-2016
researchmap Member ID: B000380981

Research Interests

Research Areas

Research History

Apr, 2022 - Present

Associate professor, Kyushu University
Dec, 2019 - Mar, 2022

Associate professor, The Institute of Scientific and Industrial Research, Osaka University
Dec, 2012 - Nov, 2019

Assistant professor, The Institute of Scientific and Industrial Research, Osaka University
Jun, 2010 - Nov, 2012

Specially appointed research associate, The Institute of Scientific and Industrial Research, Osaka University
Mar, 2010 - May, 2010

Research associate, Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University
Mar, 2008 - Feb, 2010

Postdoctoral fellow, Institute for Chemical Research, Kyoto University
Jun, 2006 - Feb, 2008

Postdoctoral associate, Department of Biochemistry and Molecular Biology, Baylor College of Medicine
Apr, 2006 - May, 2006

Graduate School of Frontier Sciences, The University of Tokyo

Education

Apr, 2004 - Mar, 2006

Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo
Apr, 2003 - Mar, 2004

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo
Apr, 2001 - Mar, 2003

Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo
Apr, 1997 - Mar, 2001

College of Biological Sciences, Second Cluster of Colleges, University of Tsukuba

Papers

A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA

Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani

Digital Discovery, 3 243-248, Jan, 2024 Peer-reviewed
A New Small Molecule DoNA Binding to CAG Repeat RNA

Qingwen Chen, Takeshi Yamada, Koichi Miyagawa, Asako Murata, Mitsuo Shoji, Kazuhiko Nakatani

Bioorganic & Medicinal Chemistry, 98 117580, Dec, 2023 Peer-reviewed
FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD.

Yuzo Fujino, Morio Ueyama, Taro Ishiguro, Daisaku Ozawa, Hayato Ito, Toshihiko Sugiki, Asako Murata, Akira Ishiguro, Tania Gendron, Kohji Mori …

eLife, 12, Jul 18, 2023 Peer-reviewed
Inhibitory Effects of Mismatch Binding Molecules on the Repair Reaction of Uracil-Containing DNA

Anisa Ulhusna, Asako Murata, Kazuhiko Nakatani

BIOCHEMISTRY, 61 2522-2530, Oct, 2022 Peer-reviewed
Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding

Yusuke Takashima, Asako Murata, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani

ACS CHEMICAL BIOLOGY, 17(10) 2817-2827, Sep 23, 2022 Corresponding author
Premature translation termination mediated non-ER stress induced ATF6 activation by a ligand-dependent ribosomal frameshifting circuit

Hsiu-Ting Hsu, Asako Murata, Chikara Dohno, Kazuhiko Nakatani, KungYao Chang

NUCLEIC ACIDS RESEARCH, 50(9) 5369-5383, May, 2022 Peer-reviewed
Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani

CHEMICAL COMMUNICATIONS, 58(22) 3629-3632, Mar, 2022
HT-SELEX-based identification of binding pre-miRNA hairpin-motif for small molecules

Sanjukta Mukherjee, Asako Murata, Ryoga Ishida, Ayako Sugai, Chikara Dohno, Michiaki Hamada, Sudhir Krishna, Kazuhiko Nakatani

MOLECULAR THERAPY-NUCLEIC ACIDS, 27 165-174, Mar, 2022 Peer-reviewed
2-Amino-1,8-naphthyridine Dimer (ANP77), a High-Affinity Binder to the Internal Loops of C/CC and T/CC Sites in Double-Stranded DNA

Bimolendu Das, Konami Nagano, Gota Kawai, Asako Murata, Kazuhiko Nakatani

JOURNAL OF ORGANIC CHEMISTRY, 87(1) 340-350, Dec, 2021 Peer-reviewed
A small-molecule fluorescence probe ANP77 for sensing RNA internal loop of C, U and A/CC motifs and their binding molecules

Bimolendu Das, Asako Murata, Kazuhiko Nakatani

Nucleic Acids Research, 49(15) 8462-8470, Sep 7, 2021 Peer-reviewed
Speeding drug discovery targeting RNAs: An iterative “RNA selection-compounds screening cycle“ for exploring RNA-small molecule pairs

Tomoko Furuzono, Asako Murata, Satoshi Okuda, Kenji Mizutani, Tsuyoshi Adachi, Kazuhiko Nakatani

Bioorganic & Medicinal Chemistry, 36 116070-116070, Apr, 2021 Peer-reviewed
Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction.

Asako Murata, Yuki Mori, Yue Di, Ayako Sugai, Bimolendu Das, Yusuke Takashima, Kazuhiko Nakatani

Biochemistry, 60(4) 245-249, Feb 2, 2021 Peer-reviewedLead author
The dimeric form of 1,3-diaminoisoquinoline derivative rescued the mis-splicing of Atp2a1 and Clcn1 genes in myotonic dystrophy type 1 mouse model.

Kazuhiko Nakatani, Jun Matsumoto, Masayuki Nakamori, Tatsumasa Okamoto, Asako Murata, Chikara Dohno

Chemistry (Weinheim an der Bergstrasse, Germany), May 25, 2020 Peer-reviewed
A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo.

Masayuki Nakamori, Gagan B Panigrahi, Stella Lanni, Terence Gall-Duncan, Hideki Hayakawa, Hana Tanaka, Jennifer Luo, Takahiro Otabe, Jinxing Li, Akihiro Sakata …

Nature genetics, 52(2) 146-159, Feb, 2020 Peer-reviewed
RT-Hpro-PCR: A MicroRNA Detection System Using a Primer with a DNA Tag

Takei Fumie, Akiyama Misaki, Murata Asako, Sugai Ayako, Nakatani Kazuhiko, Yamashita Ichiro

CHEMBIOCHEM, 21(4), Nov 7, 2019 Peer-reviewed
Structural insights into synthetic ligands targeting A–A pairs in disease-related CAG RNA repeats

Mukherjee, S, Błaszczyk, L, Rypniewski, W, Falschlunger, C, Micura, R, Murata, A, Dohno, C, Nakatani, K, Kiliszek, A

Nucl. Acids Res., 47(20) 10906-10913, Nov, 2019 Peer-reviewed
Modulating RNA secondary and tertiary structures by mismatch binding ligands

Murata Asako, Nakamori Masayuki, Nakatani Kazuhiko

METHODS, 167 78-91, Sep 1, 2019 Peer-reviewedLead author
Inhibition of pre-miRNA-136 processing by Dicer with small molecule BzDANP suggested the formation of ternary complex of pre-miR-136-BzDANP-Dicer

Otabe Takahiro, Nagano Konami, Kawai Gota, Murata Asako, Nakatani Kazuhiko

BIOORGANIC & MEDICINAL CHEMISTRY, 27(10) 2140-2148, May 15, 2019 Peer-reviewed
A Dimeric 2,9-Diamino-1,10-phenanthroline Derivative Improves Alternative Splicing in Myotonic Dystrophy Type 1 Cell and Mouse Models

Li Jinxing, Nakamori Masayuki, Matsumoto Jun, Murata Asako, Dohno Chikara, Kiliszek Agnieszka, Taylor Katarzyna, Sobczak Krzysztof, Nakatani Kazuhiko

CHEMISTRY-A EUROPEAN JOURNAL, 24(68) 18115-18122, Dec 5, 2018 Peer-reviewed
Small synthetic molecule-stabilized RNA pseudoknot as an activator for-1 ribosomal frameshifting

Matsumoto Saki, Caliskan Neva, Rodnina Marina V, Murata Asako, Nakatani Kazuhiko

NUCLEIC ACIDS RESEARCH, 46(16) 8079-8089, Sep 19, 2018 Peer-reviewedCorresponding author

Misc.

次世代を担う女性研究者マイクロRNA前駆体を標的とする低分子化合物の探索研究

村田亜沙子

化学工業, 67(4) 275-280, Apr, 2016 InvitedLead author
アカデミア創薬研究の今を知る《注目の標的からの創薬展開》6.顕在化した創薬標的マイクロRNA(miRNA)

村田亜沙子, 中谷和彦

実験医学, 32(2) 160-165, Feb, 2014 InvitedLead author
Tips for Target Identification of Bioactive Molecules

141-146, Jul, 2010 Invited
ケミカルジェネティクス:化学が教えてくれる生命機能海洋天然物のケミカルジェネティクス

佐藤慎一, 村田亜沙子, 上杉志成

細胞工学, 28(4) 332-337, Apr, 2009 Invited
iPS細胞誕生後 iPS細胞作製を効率化する化合物

村田亜沙子, 上杉志成

現代化学, (452) 37-39, Oct, 2008 InvitedLead author
Identification of the Cardiac Beta-Adrenergic Receptor Protein: Solubilization and Purification by Affinity Chromatography

Sato, S., Murata, A., Uesugi, M.

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52(13) 1782-1783, Oct, 2007 Invited
ゲノムを臨床につなげる薬の世界生物医学研究を加速するケミカルゲノミクス

村田亜沙子, 佐藤慎一, 上杉志成, 上杉志成

最新医学, 62 2205-2213, Sep, 2007 InvitedLead author

Major Presentations

115

Interaction between a small molecule, NA, and an RNA with the ACG/AUA internal loop

Aina Fujiwara, Qingwen Chen, Asako Murata, Kazuhiko Nakatani, Gota Kawai

The 50th International Symposium on Nucleic Acids Chemistry, Nov 1, 2023
Machine learning assisted classification of small molecules targeting CAG repeat DNA

Qingwen Chen, Takeshi Yamada, Asako Murata, Yasuyuki Matsushita, Kazuhiko Nakatani

The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022)
Evaluation of the effect of small-molecule binding to mRNA on ribosomal frameshifting in SARS-CoV-2

Asako Murata, Hiyori Fujii, Risa Anami, Ayako Sugai, Kazuhiko Nakatani

The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022)
A rapid method for obtaining the interacting pairs of RNA-small molecule and its statistical analysis

Yusuke Takashima, Asako Murata, Ayako Sugai, Kazuhiko Nakatani

The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022)
A Fluorescence Probe ANP77 for Sensing RNA Internal Loops and Their Binding Molecules

Bimolendu Das, Asako Murata, Kazuhiko Nakatani

The 49th International Symposium on Nucleic Acids Chemistry (ISNAC2022)
Comprehensive analysis of small molecule-target RNA pairs toward profiling small-molecule binders of RNA

Asako Murata, Yusuke Takashima, Ayumu Asai, Kazuhiko Nakatani

The 44th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2021) Invited
RNAを標的とする低分子の探索と応用

村田亜沙子

核酸化学若手フォーラム2021 Invited
Comprehensive Analysis of Dicer Substrates by High-Throughput Sequencing Identified New Target RNA Motifs for Small Molecules

Asako Murata, Yusuke Takashima, Kei Iida, Ayako Sugai, Masatoshi Hagiwara, Kazuhiko Nakatani

The 43rd Annual Meeting of the Molecular Biology Society of Japan (MBSJ2020) Invited
小分子による–1リボソーマルフレームシフト誘起とタンパク質の輸送・局在制御への応用

村田亜沙子, 松本咲, 洪昌峰, 中谷和彦

BMB2015 Biochemistry and Molecular Biology Invited
RNAの構造・機能を制御する小分子化合物の開発

村田亜沙子

The 94th CSJ Annual Meeting Invited
Fluorescent indicator displacement assay for the discovery of RNA-binding ligands

Asako Murata, Yasue Harada, Takeo Fukuzumi, Shiori Umemoto, Seongwang Im, Masaki Hagihara, Kazuhiko Nakatani

The 34th Annual Meeting of the Molecular Biology Society Japan Invited

Teaching Experience

2023

Nucleic Acids Chemistry (Kyushu University)
2014 - 2021

Genome Chemistry (Osaka University)
2017 - 2018

化学要論 (Osaka University)

Professional Memberships

2018 - Present

The Japana Society of Nucleic Acids Chemistry
2012 - Present

Japan Society for Chemical Biology
Dec, 2002 - Present

The Chemical Society of Japan

Research Projects

Development of a method for comprehensively analyzing the interaction between RNA and small molecule and analysis on big data of the RNA-small molecule binding pairs

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025

Murata Asako
Elucidation of the novel RNA secondary structure induced by a small molecule

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2024

Murata Asako
Small-molecule induced –1 ribosomal frameshifting and its application to the control of protein transport and localization

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Murata Asako
Induction of -1 ribosomal frameshifting by a small molecule and its application to protein transport and localization

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2019

Murata Asako
リピート結合分子をプローブとしたトリヌクレオチドリピート病の化学生物学研究

科学研究費助成事業特別推進研究, 特別推進研究, 日本学術振興会, 2014 - 2018

中谷和彦, 堂野主税, 村田亜沙子, 中森雅之, 武井史恵
Modulation of pre-miRNA processing by a small-molecule

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Murata Asako
Synthesis of 8-substituted purine chemical library and riboswitch-reengineering

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2015

NAKATANI Kazuhiko, TAKEI Fumie, HAGIHARA Masaki, DOHNO Chikara, MURATA Asako, FUKUZUMI Takeo, AIKAWA Haruo
Gene regulation by using an ligand-responsive miRNA pathway

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

Murata Asako

Industrial Property Rights

特許第6246125号多能性細胞を選別するための方法

上杉志成, 平田直, 村田亜沙子, チャンヨンテ, 中辻憲夫, 末盛博文, 川瀬栄八郎, 山内香織, 植田和光, 藤林悠人, 山中伸弥, 中川誠人

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Major Presentations

Teaching Experience

Professional Memberships

Research Projects

Industrial Property Rights

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