論文

査読有り 筆頭著者
2016年

Modifiable Factors Associated with Cognitive Impairment in 1,143 Japanese Outpatients: The Project in Sado for Total Health (PROST)

Dementia and Geriatric Cognitive Disorders Extra
  • Kaori Kitamura
  • Yumi Watanabe
  • Kazutoshi Nakamura
  • Kazuhiro Sanpei
  • Minako Wakasugi
  • Akio Yokoseki
  • Osamu Onodera
  • Takeshi Ikeuchi
  • Ryozo Kuwano
  • Takeshi Momotsu
  • Ichiei Narita
  • Naoto Endo
  • 全て表示

6
2
開始ページ
341
終了ページ
349
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000447963
出版者・発行元
S. Karger AG

Background/Aims: Evidence on modifiable factors associated with cognitive impairment in Japanese patients is scarce. This study aimed to determine modifiable factors for cognitive impairment in a Japanese hospital-based population. Methods: Subjects of this cross-sectional study were 1,143 patients of Sado General Hospital (Niigata, Japan) registered in the Project in Sado for Total Health (PROST) between June 2008 and September 2014. We assessed disease history, body mass index (BMI), leisure time physical activity, walking time, smoking and drinking habits, and consumption of vegetables, fruits, and green tea as predictors, with cognitive impairment defined by the Mini-Mental State Examination (score &lt
24) as an outcome. Multiple logistic regression analysis was performed to calculate odds ratios (ORs) for cognitive impairment. Results: The mean subject age was 68.9 years, and the prevalence of cognitive impairment was 21.5%. Multivariate analysis revealed that age (p &lt
0.001), low BMI (&lt
21.1
OR 1.39, 95% CI 1.12-1.72), a history of stroke (p = 0.003), a history of myocardial infarction (p = 0.038), low fruit consumption (p for trend = 0.012), and low green tea consumption (p for trend = 0.032) were independently associated with a higher prevalence of cognitive impairment. Conclusions: Modifiable factors, such as low BMI, low fruit consumption, and low green tea consumption, are associated with cognitive impairment. Longitudinal studies will be needed to confirm these findings.

リンク情報
DOI
https://doi.org/10.1159/000447963
ID情報
  • DOI : 10.1159/000447963
  • ISSN : 1664-5464
  • SCOPUS ID : 84986881459

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