論文

査読有り
2017年12月

The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans

CELL REPORTS
  • Sakiko Honjoh
  • ,
  • Akiko Ihara
  • ,
  • Yukiko Kajiwara
  • ,
  • Takuya Yamamoto
  • ,
  • Eisuke Nishida

21
13
開始ページ
3646
終了ページ
3652
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.celrep.2017.11.108
出版者・発行元
CELL PRESS

Organismal lifespan is highly plastic in response to environmental cues, and dietary restriction (DR) is the most robust way to extend lifespan in various species. Recent studies have shown that sex also is an important factor for lifespan regulation; however, it remains largely unclear how these two factors, food and sex, interact in lifespan regulation. The nematode Caenorhabditis elegans has two sexes, hermaphrodite and male, and only the hermaphrodites are essential for the short-term succession of the species. Here, we report an extreme sexual dimorphism in the responsiveness to DR in C. elegans; the essential hermaphrodites show marked longevity responses to various forms of DR, but the males show few longevity responses and sustain reproductive ability. Our analysis reveals that the sex determination pathway and the steroid hormone receptor DAF-12 regulate the sex-specific DR responsiveness, integrating sex and environmental cues to determine organismal lifespan.

Web of Science ® 被引用回数 : 12

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2017.11.108
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29281814
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000418721800002&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.celrep.2017.11.108
  • ISSN : 2211-1247
  • PubMed ID : 29281814
  • Web of Science ID : WOS:000418721800002

エクスポート
BibTeX RIS