論文

査読有り
2017年10月

The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16/FOXO transcription factors

EMBO REPORTS
  • Takako Ikeda
  • ,
  • Masaharu Uno
  • ,
  • Sakiko Honjoh
  • ,
  • Eisuke Nishida

18
10
開始ページ
1716
終了ページ
1726
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.15252/embr.201743907
出版者・発行元
WILEY

The well-known link between longevity and the Sir2 histone deacetylase family suggests that histone deacetylation, a modification associated with repressed chromatin, is beneficial to longevity. However, the molecular links between histone acetylation and longevity remain unclear. Here, we report an unexpected finding that the MYST family histone acetyltransferase complex (MYS-1/TRR-1 complex) promotes rather than inhibits stress resistance and longevity in Caenorhabditis elegans. Our results show that these beneficial effects are largely mediated through transcriptional up-regulation of the FOXO transcription factor DAF-16. MYS-1 and TRR-1 are recruited to the promoter regions of the daf-16 gene, where they play a role in histone acetylation, including H4K16 acetylation. Remarkably, we also find that the human MYST family Tip60/TRRAP complex promotes oxidative stress resistance by up-regulating the expression of FOXO transcription factors in human cells. Tip60 is recruited to the promoter regions of the foxo1 gene, where it increases H4K16 acetylation levels. Our results thus identify the evolutionarily conserved role of the MYST family acetyltransferase as a key epigenetic regulator of DAF-16/FOXO transcription factors.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.15252/embr.201743907
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28794203
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000412116400009&DestApp=WOS_CPL
ID情報
  • DOI : 10.15252/embr.201743907
  • ISSN : 1469-221X
  • eISSN : 1469-3178
  • PubMed ID : 28794203
  • Web of Science ID : WOS:000412116400009

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