論文

査読有り
2016年2月

Local Slow Waves in Superficial Layers of Primary Cortical Areas during REM Sleep

CURRENT BIOLOGY
  • Chadd M. Funk
  • ,
  • Sakiko Honjoh
  • ,
  • Alexander V. Rodriguez
  • ,
  • Chiara Cirelli
  • ,
  • Giulio Tononi

26
3
開始ページ
396
終了ページ
403
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.cub.2015.11.062
出版者・発行元
CELL PRESS

Sleep is traditionally constituted of two global behavioral states, non-rapid eye movement (NREM) and rapid eye movement (REM), characterized by quiescence and reduced responsiveness to sensory stimuli [1]. NREM sleep is distinguished by slow waves and spindles throughout the cerebral cortex and REM sleep by an "activated,'' low-voltage fast electroencephalogram (EEG) paradoxically similar to that of wake, accompanied by rapid eye movements and muscle atonia. However, recent evidence has shown that cortical activity patterns during wake and NREM sleep are not as global as previously thought. Local slow waves can appear in various cortical regions in both awake humans [2] and rodents [3-5]. Intracranial recordings in humans [6] and rodents [4, 7] have shown that NREM sleep slow waves most often involve only a subset of brain regions that varies from wave to wave rather than occurring near synchronously across all cortical areas. Moreover, some cortical areas can transiently "wake up'' [8] in an otherwise sleeping brain. Yet until now, cortical activity during REM sleep was thought to be homogenously wake-like. We show here, using local laminar recordings in freely moving mice, that slow waves occur regularly during REM sleep, but only in primary sensory and motor areas and mostly in layer 4, the main target of relay thalamic inputs, and layer 3. This finding may help explain why, during REM sleep, we remain disconnected from the environment even though the bulk of the cortex shows wake-like, paradoxical activation.

Web of Science ® 被引用回数 : 76

リンク情報
DOI
https://doi.org/10.1016/j.cub.2015.11.062
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26804554
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369502900033&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.cub.2015.11.062
  • ISSN : 0960-9822
  • eISSN : 1879-0445
  • PubMed ID : 26804554
  • Web of Science ID : WOS:000369502900033

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