論文

査読有り
2013年1月

A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans

CELL REPORTS
  • Masaharu Uno
  • ,
  • Sakiko Honjoh
  • ,
  • Mitsuhiro Matsuda
  • ,
  • Haruka Hoshikawa
  • ,
  • Saya Kishimoto
  • ,
  • Tomohito Yamamoto
  • ,
  • Miki Ebisuya
  • ,
  • Takuya Yamamoto
  • ,
  • Kunihiro Matsumoto
  • ,
  • Eisuke Nishida

3
1
開始ページ
79
終了ページ
91
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.celrep.2012.12.018
出版者・発行元
CELL PRESS

Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce the fasting stimulus remain largely unknown. Through a comprehensive transcriptome analysis in C. elegans, we find that along with the FOXO transcription factor DAF-16, AP-1 (JUN-1/FOS-1) plays a central role in fasting-induced transcriptional changes. KGB-1, one of the C. elegans JNKs, acts as an activator of AP-1 and is activated in response to fasting. KGB-1 and AP-1 are involved in intermittent fasting-induced longevity. Fasting-induced upregulation of the components of the SCF E3 ubiquitin ligase complex via AP-1 and DAF-16 enhances protein ubiquitination and reduces protein carbonylation. Our results thus identify a fasting-responsive KGB-1/AP-1 signaling pathway, which, together with DAF-16, causes transcriptional changes that mediate longevity, partly through regulating proteostasis.

Web of Science ® 被引用回数 : 60

リンク情報
DOI
https://doi.org/10.1016/j.celrep.2012.12.018
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23352664
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000321891400011&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.celrep.2012.12.018
  • ISSN : 2211-1247
  • PubMed ID : 23352664
  • Web of Science ID : WOS:000321891400011

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