論文

査読有り
2011年

Two sides of lifespan regulating genes: pro-longevity or anti-longevity?

JOURNAL OF BIOCHEMISTRY
  • Sakiko Honjoh
  • ,
  • Eisuke Nishida

149
4
開始ページ
381
終了ページ
388
記述言語
英語
掲載種別
DOI
10.1093/jb/mvr026
出版者・発行元
OXFORD UNIV PRESS

Traditionally, ageing has been considered a passive and entropic process, in which damages accumulate on biological macromolecules over time and the accumulated damages lead to a decline in overall physiological functions. However, the discovery of a longevity mutant in the nematode Caenorhabditis elegans has challenged this view. A longevity mutant is a mutant organism, in which a reduction-of-function of a certain gene prolongs the lifespan. Thus, the discovery of longevity mutants has shown the existence of genes, which function to shorten lifespan in wild-type organisms, promoting extensive hunting for longevity-regulating genes in short-lived model organisms, such as yeast, worms and flies. These studies have revealed remarkable conservation of longevity-regulating genes and their networks among species. Decreased insulin/IGF-like signalling and decreased target of rapamycin (TOR) signalling are both shown to extend lifespan in evolutionarily divergent species, from unicellular organisms to mammals. Intriguingly, most of these longevity-regulating pathways reveal pro-longevity and anti-longevity effects on lifespan, depending on biological and environmental contexts. This review summarizes pleiotropic functions of the conserved longevity-regulating genes or pathways, focusing on studies in C. elegans.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1093/jb/mvr026
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21372089
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000288800100003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1093/jb/mvr026
  • ISSN : 0021-924X
  • PubMed ID : 21372089
  • Web of Science ID : WOS:000288800100003

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