論文

査読有り 本文へのリンクあり
2014年

Enhancement of endothelial function inhibits left atrial thrombi development in an animal model of spontaneous left atrial thrombosis

Circulation Journal
  • Kazuaki Mawatari
  • Emiko Yoshioka
  • Satomi Toda
  • Sonoko Yasui
  • Hiroko Furukawa
  • Takaaki Shimohata
  • Takamasa Ohnishi
  • Masaki Morishima
  • Nagakatsu Harada
  • Akira Takahashi
  • Hiroshi Sakaue
  • Yutaka Nakaya
  • 全て表示

78
8
開始ページ
1980
終了ページ
1988
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1253/circj.CJ-13-1398

Background: Left atrial (LA) thrombosis is an important cause of systemic embolization. The SPORTS rat model of LA thrombi (Spontaneously-Running Tokushima-Shikoku), which have a unique characteristic of high voluntary wheel running, was previously established. The aim of the present study was to investigate how SPORTS rats develop LA thrombi. Methods and Results: Nitric oxide (NO) produced from cardiovascular endothelial cells plays an important protective role in the local regulation of blood flow, vascular tone, and platelet aggregation. No evidence of atrial fibrillation or hypercoagulability in SPORTS rats regardless of age was found; however, SPORTS rats demonstrated endothelial dysfunction and a decrease of NO production from a young age. In addition, endothelial NO synthase activity was significantly decreased in the LA and thoracic aorta endothelia of SPORTS rats. While voluntary wheel running was able to intermittently increase NO levels, running did not statistically decrease the incidence of LA thrombi at autopsy. However, L-arginine treatment significantly increased NO production and provided protection from the development of LA thrombi in SPORTS rats. Conclusions: They present study results indicate that NO has an important role in the development of LA thrombus, and endothelia pathways could provide new targets of therapy to prevent LA thrombosis.

リンク情報
DOI
https://doi.org/10.1253/circj.CJ-13-1398
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24859498
Scopus
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84905043629&origin=inward 本文へのリンクあり
Scopus Citedby
https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84905043629&origin=inward
ID情報
  • DOI : 10.1253/circj.CJ-13-1398
  • ISSN : 1346-9843
  • eISSN : 1347-4820
  • PubMed ID : 24859498
  • SCOPUS ID : 84905043629

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