Taisuke Tomita Last updated: Jun 7, 2019 at 13:19
Name
Taisuke Tomita Nickname
taisuke E-mail
taisuke Affiliation
The University of Tokyo Research funding number
30292957 ORCID ID
0000-0002-0075-5943
Academic & Professional Experience
Apr 2014
-
Today
Professor, Gradsuate School of Pharmaceutical Sciences, The University of Tokyo
Awards & Honors
2015
NAGASE Foundation Award 2015, NAGASE Science Technology Foundation
2013
Basic Research Award, Japan Society for Dementia Research Award, Japan Society for Dementia Research
2011
Second Prize, Erwin von Bälz Prize, Boehringer Ingelheim
2010
Basic Research, Presentation Award, Japan Society for Dementia Research
Published Papers
Journal of Biological Chemistry May 2019 [Refereed]
Tobias Brummer, Stephan A Müller, Francisco Pan-Montojo, Fumiaki Yoshida, Andreas Fellgiebel, Taisuke Tomita, Kristina Endres, Stefan F Lichtenthaler
EMBO Molecular Medicine 11(4) e9695 Apr 2019 [Refereed]
Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Taisuke Tomita
Chemical Communications 2019 [Refereed]
Kunihiko Kanatsu, Yukiko Hori, Ihori Ebinuma, Yung Wen Chiu, Taisuke Tomita
Journal of Neurochemistry 147(1) 110-123 Aug 2018 [Refereed]
Imai S, Cai T, Yoshida C, Tomita T, Futai E.
Journal of biochemistry 165(1) 37-46 2019 [Refereed]
Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido T.C, Tomita T, Sohma Y, Kanai M.
Chem 4(4) 807-820 2018 [Refereed]
Miho Araki, Genta Ito, Taisuke Tomita
Neuronal Signaling NS20180005 Dec 2018 [Refereed]
Tetsuo Cai, Masahiro Yonaga, Taisuke Tomita
The Journal of Neuroscience 37(50) 12272-12280 Dec 2017 [Refereed]
Kazunori Kikuchi, Kiwami Kidana, Takuya Tatebe, Taisuke Tomita
Journal of Cellular Biochemistry 118(12) 4183-4190 Dec 2017 [Refereed]
Sho Takatori, Taisuke Tomita
Advances in Experimental Medicine and Biology 2018 [Refereed]
Ito K, Tatebe T, Suzuki K, Hirayama T, Hayakawa M, Kubo H, Tomita T, Makino M
European journal of pharmacology 798 16-25 Feb 2017 [Refereed]
Nakamura A, Kaneko N, Villemagne V.L, Kato T, Doecke J, Dor{é} V, Fowler C, Li Q.-X, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters C.L, Yanagisawa K.
Nature 554(7691) 249-254 2018 [Refereed]
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido T.C, Akishita M, Iwatsubo T, Hori Y, Tomita T.
EMBO Molecular Medicine 10(3) 2018 [Refereed]
Tomita T
Advances in biological regulation 64 33-38 Jan 2017 [Refereed]
Takahashi-Ito K, Makino M, Okado K, Tomita T.
Biochemical and Biophysical Research Communications 493(1) 158-163 2017 [Refereed]
Kanatsu K, Tomita T.
Frontiers in bioscience (Landmark edition) 22 180-192 2017 [Refereed]
Tomita T.
Methods in Enzymology 584 185-205 2017 [Refereed]
Ito G, Tomita T.
Journal of Visualized Experiments 2017(130) 2017 [Refereed]
Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease.
Kanatsu K, Tomita T
Frontiers in bioscience (Landmark edition) 22 180-192 Jan 2017 [Refereed]
Sakurai S, Tomita T, Shimizu T, Ohto U.
Acta Crystallographica Section:F Structural Biology Communications 73 130-137 2017 [Refereed]
Liu C.Y, Ohki Y, Tomita T, Osawa S, Reed B.R, Jagust W, Van Berlo V, Jin L.-W, Chui H.C, Coppola G, Ringman J.M.
Journal of Alzheimer's Disease 58(4) 1035-1041 2017 [Refereed]
Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T
Human molecular genetics 25(18) 3988-3997 Sep 2016 [Refereed]
Kanatsu K, Tomita T
Biological chemistry 397(9) 827-835 Sep 2016 [Refereed]
Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S
Scientific reports 6 30442 Jul 2016 [Refereed]
Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T
Human molecular genetics 25(14) 2948-2958 Jul 2016 [Refereed]
Reinhardt S, Grimm MO, Stahlmann C, Hartmann T, Shudo K, Tomita T, Endres K
Current Alzheimer research 13(11) 1277-1289 Jun 2016 [Refereed]
Ueda N, Tomita T, Yanagisawa K, Kimura N
Journal of neurochemistry 137(4) 647-658 May 2016 [Refereed]
Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T
Scientific reports 6 23969 Apr 2016 [Refereed]
Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T
The Journal of neuroscience : the official journal of the Society for Neuroscience 36(4) 1362-1372 Jan 2016 [Refereed]
Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T
The Journal of biological chemistry 291(1) 435-446 Jan 2016 [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine 74(3) 427-431 2016 [Refereed]
Nakayama M, Kondo T, Tian Z, Ishikawa J.J, Halim M, Bareille C, Malaeb W, Kuroda K, Tomita T, Ideta S, Tanaka K, Matsunami M, Kimura S, Inami N, Ono K, Kumigashira H, Balents L, Nakatsuji S, Shin S.
Physical Review Letters 117(5) 2016 [Refereed]
[BACE1 inhibitors for the treatment of Alzheimer disease].
Tomita T
Nihon rinsho. Japanese journal of clinical medicine 74(3) 427-431 Mar 2016 [Refereed]
Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Yasuyoshi Ouchi, Masahiro Akishita, Takeshi Iwatsubo
Alzheimer's & Dementia 11(7) P504 Jul 2015 [Refereed]
Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T
The Journal of neuroscience : the official journal of the Society for Neuroscience 35(6) 2646-2656 Feb 2015 [Refereed]
Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T
Biochemical and biophysical research communications 457(2) 194-199 Feb 2015 [Refereed]
Eugene Futai, Satoko Osawa, Tetsuo Cai, Tomoya Fujisawa, Shoichi Ishiura, Taisuke Tomita
J. Biol. Chem. 291(1) 435 Nov 2015 [Refereed]
Taisuke Tomita, Aya Tominaga, Shizuka Takagi-Niidome, Takeshi Iwatsubo
Alzheimer's & Dementia 10(4) P636 Jul 2014 [Refereed]
Tomita T
Journal of biochemistry 156(4) 195-201 Oct 2014 [Refereed]
Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T
Bioorganic & medicinal chemistry letters 24(13) 2831-2833 Jul 2014 [Refereed]
Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T, Iwatsubo T
Proceedings of the National Academy of Sciences of the United States of America 111(29) 10544-10549 Jul 2014 [Refereed]
Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K
Proceedings of the National Academy of Sciences of the United States of America 111(16) 5986-5991 Apr 2014 [Refereed]
Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T
Nature communications 5 3386 Feb 2014 [Refereed]
Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
Molecular neurodegeneration 9(1) 7 Jan 2014 [Refereed]
Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M
Angewandte Chemie (International ed. in English) 53(5) 1382-1385 Jan 2014 [Refereed]
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH
Structure (London, England : 1993) 22(1) 125-135 Jan 2014 [Refereed]
[Modulation of intramembrane proteolysis and its biological function].
Tomita T
Seikagaku. The Journal of Japanese Biochemical Society 86(1) 28-40 Feb 2014 [Refereed]
Tomita T.
Seikagaku 86(1) 28-40 2014 [Refereed]
Morohashi Y, Tomita T
Biochimica et biophysica acta 1828(12) 2855-2861 Dec 2013 [Refereed]
Nobumasa Takasugi, Tomoki Sasaki, Taisuke Tomita, Takeshi Iwatsubo
Alzheimer's & Dementia 9(4) P184 Jul 2013 [Refereed]
Taisuke Tomita, Kunimichi Suzuki, Azusa Shiohara, Satoko Osawa, Takeshi Iwatsubo
Alzheimer's & Dementia 9(4) P144 Jul 2013 [Refereed]
Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T
BMC biochemistry 14(1) 16 Jul 2013 [Refereed]
Tomita T, Iwatsubo T
The Journal of biological chemistry 288(21) 14673-14680 May 2013 [Refereed]
Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T
Journal of medicinal chemistry 56(4) 1443-1454 Feb 2013 [Refereed]
Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T
Biochemistry 52(1) 61-69 Jan 2013 [Refereed]
Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y
Rinsho shinkeigaku = Clinical neurology 53(11) 956 2013 [Refereed]
Atsuhiko Taniguchi, Daisuke Sasaki, Azusa Shiohara, Takeshi Iwatsubo, Taisuke Tomita, Youhei Sohma, Motomu Kanai
Angew. Chem. 126(5) 1406 2013 [Refereed]
Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T
PLoS ONE 8(5) e64050 2013 [Refereed]
Toyn J.H, Rowley A, Matsuoka Y, Tomita T, Imbimbo B.P
International Journal of Alzheimer's Disease 2013 849128 2013 [Refereed]
Takeshi Iwatsubo, Tadafumi Hashimoto, Tomoko Wakabayashi, Taisuke Tomita, Yuichi Morohashi
Rinsho Shinkeigaku 53(11) 956 2013 [Refereed]
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T
Neuron 76(2) 410-422 Oct 2012 [Refereed]
Takeo K, Watanabe N, Tomita T, Iwatsubo T
The Journal of biological chemistry 287(31) 25834-25843 Jul 2012 [Refereed]
Taisuke Tomita, Yuichi Morohashi, Kunihiko Kanatsu, Takeshi Iwatsubo
Alzheimer's & Dementia 8(4) P312 Jul 2012 [Refereed]
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong P.C, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
Oncogene 31(6) 787-798 2012 [Refereed]
[Understanding the structure-and-function relationships of gamma-secretase toward the modulation of intramembrane-cleaving activity].
Tomita T
Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 8 321-325 Nov 2012 [Refereed]
Tomita T
Clinical Neurology 52(11) 1165-1167 2012 [Refereed]
Taisuke Tomita
Molecular Neurodegeneration 7(Suppl 1) L5 2012 [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 8 321-325 2012 [Refereed]
Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S
The Journal of biological chemistry 286(52) 44569-44575 Dec 2011 [Refereed]
Tomita T
Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 8 98-102 Oct 2011 [Refereed]
Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
The EMBO journal 30(23) 4815-4824 Oct 2011 [Refereed]
Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T
The Journal of biological chemistry 286(29) 26188-26197 Jul 2011 [Refereed]
Taisuke Tomita, Nobumasa Takasugi, Tomoki Sasaki, Satoko Osawa, Satoshi Yokoshima, Tohru Fukuyama, Virginia Lee, John Trojanowski, Takeshi Iwatsubo
Alzheimer's & Dementia 7(4) S411 Jul 2011 [Refereed]
Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience 31(18) 6850-6857 May 2011 [Refereed]
Tomita T, Wong PC
Alzheimer's research & therapy 3(2) 7 Mar 2011 [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine 69 Suppl 8 98-102 2011 [Refereed]
Tomita T, Sakurai Y, Ishibashi S, Maru Y.
Oncogene 30(31) 3429-3439 2011 [Refereed]
Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K
Journal of neuroscience research 88(16) 3588-3597 Dec 2010 [Refereed]
Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience 30(47) 15943-15950 Nov 2010 [Refereed]
Morohashi Y, Tomita T, Iwatsubo T
Nihon rinsho. Japanese journal of clinical medicine 68(10) 1906-1910 Oct 2010 [Refereed]
Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H
Bioorganic & medicinal chemistry letters 20(17) 5282-5285 Sep 2010 [Refereed]
Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M
The Journal of neuroscience : the official journal of the Society for Neuroscience 30(33) 11157-11166 Aug 2010 [Refereed]
Taisuke Tomita
Alzheimer's & Dementia 6(4) S93 Jul 2010 [Refereed]
Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I
The Journal of biological chemistry 285(26) 19738-19746 Jun 2010 [Refereed]
Morohashi Y, Tomita T, Iwatsubo T.
Nippon rinsho. Japanese journal of clinical medicine 68(10) 1906-1910 2010 [Refereed]
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T
Bioorganic and Medicinal Chemistry Letters 20(5) 1798-1799 2010 [Refereed]
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T
Bioorganic & medicinal chemistry letters 19(24) 6869-6871 Dec 2009 [Refereed]
Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S
Cancer science 100(12) 2444-2450 Dec 2009 [Refereed]
Tomita T
Rinsho shinkeigaku = Clinical neurology 49(11) 845-847 Nov 2009 [Refereed]
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T
The Journal of biological chemistry 284(41) 27838-27847 Oct 2009 [Refereed]
Tomita T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(13) 1747-1753 Oct 2009 [Refereed]
Tomita T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(12 Suppl) 1684-1689 Sep 2009 [Refereed]
Hiroyuki Miyashita, Yuusuke Maruyama, Toshihiko Ogura, Kazuhiro Mio, Takeshi Iwatsubo, Taisuke Tomita, Chikara Sato
Alzheimer's & Dementia 5(4) P317 Jul 2009 [Refereed]
Taisuke Tomita, Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Tatsuhiko Kodama, Takao Hamakubo, Takeshi Iwatsubo
Alzheimer's & Dementia 5(4) P87 Jul 2009 [Refereed]
Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T
Journal of the American Chemical Society 131(21) 7353-7359 Jun 2009 [Refereed]
Tomita T
Expert review of neurotherapeutics 9(5) 661-679 May 2009 [Refereed]
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G
The Journal of biological chemistry 284(3) 1373-1384 Jan 2009 [Refereed]
Tomita T.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(13) 1747-1753 2009 [Refereed]
Tomita T.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 54(12 Suppl) 1684-1689 2009 [Refereed]
Tomita T
Rinsho shinkeigaku = Clinical neurology 48(11) 907-909 Nov 2008 [Refereed]
Research Grants & Projects
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(S))
Project Year: 2007 - 2011 Investigator(s): Taisuke TOMITA
γ-Secretase is an intramembrane protease that is responsible for the generation of amyloid-βpeptide linked to the pathogenesis of Alzheimer disease. Thus, modulation ofγ-secretase activity is a plausible therapeutics for Alzheimer disease. We have...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007 Investigator(s): Taisuke TOMITA
Several lines of evidence suggest that aggregation and deposition of amyloid-β peptide (Aβ) are involved in the pathogenesis of Alzheimer's dipease, that is the most common cause of dementia with aging. Thus, γ-secretase, that is a pivotal enzyme ...
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