Taisuke Tomita

J-GLOBAL         Last updated: Jun 7, 2019 at 13:19
 
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Name
Taisuke Tomita
Nickname
taisuke
E-mail
taisukemol.f.u-tokyo.ac.jp
Affiliation
The University of Tokyo
Research funding number
30292957
ORCID ID
0000-0002-0075-5943

Research Areas

 
 

Academic & Professional Experience

 
Apr 2014
 - 
Today
Professor, Gradsuate School of Pharmaceutical Sciences, The University of Tokyo
 

Awards & Honors

 
2015
NAGASE Foundation Award 2015, NAGASE Science Technology Foundation
 
2013
Basic Research Award, Japan Society for Dementia Research Award, Japan Society for Dementia Research
 
2011
Second Prize, Erwin von Bälz Prize, Boehringer Ingelheim
 
2010
Basic Research, Presentation Award, Japan Society for Dementia Research
 

Published Papers

 
Tobias Brummer, Stephan A Müller, Francisco Pan-Montojo, Fumiaki Yoshida, Andreas Fellgiebel, Taisuke Tomita, Kristina Endres, Stefan F Lichtenthaler
EMBO Molecular Medicine   11(4) e9695   Apr 2019   [Refereed]
Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Taisuke Tomita
Chemical Communications      2019   [Refereed]
Kunihiko Kanatsu, Yukiko Hori, Ihori Ebinuma, Yung Wen Chiu, Taisuke Tomita
Journal of Neurochemistry   147(1) 110-123   Aug 2018   [Refereed]
Imai S, Cai T, Yoshida C, Tomita T, Futai E.
Journal of biochemistry   165(1) 37-46   2019   [Refereed]
Ni J, Taniguchi A, Ozawa S, Hori Y, Kuninobu Y, Saito T, Saido T.C, Tomita T, Sohma Y, Kanai M.
Chem   4(4) 807-820   2018   [Refereed]
Miho Araki, Genta Ito, Taisuke Tomita
Neuronal Signaling   NS20180005   Dec 2018   [Refereed]
Tetsuo Cai, Masahiro Yonaga, Taisuke Tomita
The Journal of Neuroscience   37(50) 12272-12280   Dec 2017   [Refereed]
Kazunori Kikuchi, Kiwami Kidana, Takuya Tatebe, Taisuke Tomita
Journal of Cellular Biochemistry   118(12) 4183-4190   Dec 2017   [Refereed]
Sho Takatori, Taisuke Tomita
Advances in Experimental Medicine and Biology      2018   [Refereed]
Ito K, Tatebe T, Suzuki K, Hirayama T, Hayakawa M, Kubo H, Tomita T, Makino M
European journal of pharmacology   798 16-25   Feb 2017   [Refereed]
Nakamura A, Kaneko N, Villemagne V.L, Kato T, Doecke J, Dor{é} V, Fowler C, Li Q.-X, Martins R, Rowe C, Tomita T, Matsuzaki K, Ishii K, Ishii K, Arahata Y, Iwamoto S, Ito K, Tanaka K, Masters C.L, Yanagisawa K.
Nature   554(7691) 249-254   2018   [Refereed]
Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido T.C, Akishita M, Iwatsubo T, Hori Y, Tomita T.
EMBO Molecular Medicine   10(3)    2018   [Refereed]
Tomita T
Advances in biological regulation   64 33-38   Jan 2017   [Refereed]
Takahashi-Ito K, Makino M, Okado K, Tomita T.
Biochemical and Biophysical Research Communications   493(1) 158-163   2017   [Refereed]
Kanatsu K, Tomita T.
Frontiers in bioscience (Landmark edition)   22 180-192   2017   [Refereed]
Tomita T.
Methods in Enzymology   584 185-205   2017   [Refereed]
Ito G, Tomita T.
Journal of Visualized Experiments   2017(130)    2017   [Refereed]
Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease.
Kanatsu K, Tomita T
Frontiers in bioscience (Landmark edition)   22 180-192   Jan 2017   [Refereed]
Sakurai S, Tomita T, Shimizu T, Ohto U.
Acta Crystallographica Section:F Structural Biology Communications   73 130-137   2017   [Refereed]
Liu C.Y, Ohki Y, Tomita T, Osawa S, Reed B.R, Jagust W, Van Berlo V, Jin L.-W, Chui H.C, Coppola G, Ringman J.M.
Journal of Alzheimer's Disease   58(4) 1035-1041   2017   [Refereed]
Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T
Human molecular genetics   25(18) 3988-3997   Sep 2016   [Refereed]
Kanatsu K, Tomita T
Biological chemistry   397(9) 827-835   Sep 2016   [Refereed]
Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Kimura-Someya T, Shirouzu M, Yokoyama S
Scientific reports   6 30442   Jul 2016   [Refereed]
Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Young Chang M, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T
Human molecular genetics   25(14) 2948-2958   Jul 2016   [Refereed]
Reinhardt S, Grimm MO, Stahlmann C, Hartmann T, Shudo K, Tomita T, Endres K
Current Alzheimer research   13(11) 1277-1289   Jun 2016   [Refereed]
Ueda N, Tomita T, Yanagisawa K, Kimura N
Journal of neurochemistry   137(4) 647-658   May 2016   [Refereed]
Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T
Scientific reports   6 23969   Apr 2016   [Refereed]
Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T
The Journal of neuroscience : the official journal of the Society for Neuroscience   36(4) 1362-1372   Jan 2016   [Refereed]
Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T
The Journal of biological chemistry   291(1) 435-446   Jan 2016   [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine   74(3) 427-431   2016   [Refereed]
Nakayama M, Kondo T, Tian Z, Ishikawa J.J, Halim M, Bareille C, Malaeb W, Kuroda K, Tomita T, Ideta S, Tanaka K, Matsunami M, Kimura S, Inami N, Ono K, Kumigashira H, Balents L, Nakatsuji S, Shin S.
Physical Review Letters   117(5)    2016   [Refereed]
[BACE1 inhibitors for the treatment of Alzheimer disease].
Tomita T
Nihon rinsho. Japanese journal of clinical medicine   74(3) 427-431   Mar 2016   [Refereed]
Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Yasuyoshi Ouchi, Masahiro Akishita, Takeshi Iwatsubo
Alzheimer's & Dementia   11(7) P504   Jul 2015   [Refereed]
Takagi-Niidome S, Sasaki T, Osawa S, Sato T, Morishima K, Cai T, Iwatsubo T, Tomita T
The Journal of neuroscience : the official journal of the Society for Neuroscience   35(6) 2646-2656   Feb 2015   [Refereed]
Takasugi N, Sasaki T, Shinohara M, Iwatsubo T, Tomita T
Biochemical and biophysical research communications   457(2) 194-199   Feb 2015   [Refereed]
Eugene Futai, Satoko Osawa, Tetsuo Cai, Tomoya Fujisawa, Shoichi Ishiura, Taisuke Tomita
J. Biol. Chem.   291(1) 435   Nov 2015   [Refereed]
Taisuke Tomita, Aya Tominaga, Shizuka Takagi-Niidome, Takeshi Iwatsubo
Alzheimer's & Dementia   10(4) P636   Jul 2014   [Refereed]
Tomita T
Journal of biochemistry   156(4) 195-201   Oct 2014   [Refereed]
Yonezawa H, Nishiyama Y, Takeo K, Iwatsubo T, Tomita T, Yokoshima S, Fukuyama T
Bioorganic & medicinal chemistry letters   24(13) 2831-2833   Jul 2014   [Refereed]
Takeo K, Tanimura S, Shinoda T, Osawa S, Zahariev IK, Takegami N, Ishizuka-Katsura Y, Shinya N, Takagi-Niidome S, Tominaga A, Ohsawa N, Kimura-Someya T, Shirouzu M, Yokoshima S, Yokoyama S, Fukuyama T, Tomita T, Iwatsubo T
Proceedings of the National Academy of Sciences of the United States of America   111(29) 10544-10549   Jul 2014   [Refereed]
Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K
Proceedings of the National Academy of Sciences of the United States of America   111(16) 5986-5991   Apr 2014   [Refereed]
Kanatsu K, Morohashi Y, Suzuki M, Kuroda H, Watanabe T, Tomita T, Iwatsubo T
Nature communications   5 3386   Feb 2014   [Refereed]
Ohki Y, Shimada N, Tominaga A, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
Molecular neurodegeneration   9(1) 7   Jan 2014   [Refereed]
Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M
Angewandte Chemie (International ed. in English)   53(5) 1382-1385   Jan 2014   [Refereed]
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH
Structure (London, England : 1993)   22(1) 125-135   Jan 2014   [Refereed]
[Modulation of intramembrane proteolysis and its biological function].
Tomita T
Seikagaku. The Journal of Japanese Biochemical Society   86(1) 28-40   Feb 2014   [Refereed]
Tomita T.
Seikagaku   86(1) 28-40   2014   [Refereed]
Morohashi Y, Tomita T
Biochimica et biophysica acta   1828(12) 2855-2861   Dec 2013   [Refereed]
Nobumasa Takasugi, Tomoki Sasaki, Taisuke Tomita, Takeshi Iwatsubo
Alzheimer's & Dementia   9(4) P184   Jul 2013   [Refereed]
Taisuke Tomita, Kunimichi Suzuki, Azusa Shiohara, Satoko Osawa, Takeshi Iwatsubo
Alzheimer's & Dementia   9(4) P144   Jul 2013   [Refereed]
Hoshi M, Ohki Y, Ito K, Tomita T, Iwatsubo T, Ishimaru Y, Abe K, Asakura T
BMC biochemistry   14(1) 16   Jul 2013   [Refereed]
Tomita T, Iwatsubo T
The Journal of biological chemistry   288(21) 14673-14680   May 2013   [Refereed]
Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T, Higuchi T
Journal of medicinal chemistry   56(4) 1443-1454   Feb 2013   [Refereed]
Takagi-Niidome S, Osawa S, Tomita T, Iwatsubo T
Biochemistry   52(1) 61-69   Jan 2013   [Refereed]
Iwatsubo T, Hashimoto T, Wakabayashi T, Tomita T, Morohashi Y
Rinsho shinkeigaku = Clinical neurology   53(11) 956   2013   [Refereed]
Atsuhiko Taniguchi, Daisuke Sasaki, Azusa Shiohara, Takeshi Iwatsubo, Taisuke Tomita, Youhei Sohma, Motomu Kanai
Angew. Chem.   126(5) 1406   2013   [Refereed]
Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T
PLoS ONE   8(5) e64050   2013   [Refereed]
Toyn J.H, Rowley A, Matsuoka Y, Tomita T, Imbimbo B.P
International Journal of Alzheimer's Disease   2013 849128   2013   [Refereed]
Takeshi Iwatsubo, Tadafumi Hashimoto, Tomoko Wakabayashi, Taisuke Tomita, Yuichi Morohashi
Rinsho Shinkeigaku   53(11) 956   2013   [Refereed]
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T
Neuron   76(2) 410-422   Oct 2012   [Refereed]
Takeo K, Watanabe N, Tomita T, Iwatsubo T
The Journal of biological chemistry   287(31) 25834-25843   Jul 2012   [Refereed]
Taisuke Tomita, Yuichi Morohashi, Kunihiko Kanatsu, Takeshi Iwatsubo
Alzheimer's & Dementia   8(4) P312   Jul 2012   [Refereed]
Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong P.C, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
Oncogene   31(6) 787-798   2012   [Refereed]
[Understanding the structure-and-function relationships of gamma-secretase toward the modulation of intramembrane-cleaving activity].
Tomita T
Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 8 321-325   Nov 2012   [Refereed]
Tomita T
Clinical Neurology   52(11) 1165-1167   2012   [Refereed]
Taisuke Tomita
Molecular Neurodegeneration   7(Suppl 1) L5   2012   [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine   70 Suppl 8 321-325   2012   [Refereed]
Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S
The Journal of biological chemistry   286(52) 44569-44575   Dec 2011   [Refereed]
Tomita T
Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 8 98-102   Oct 2011   [Refereed]
Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
The EMBO journal   30(23) 4815-4824   Oct 2011   [Refereed]
Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T
The Journal of biological chemistry   286(29) 26188-26197   Jul 2011   [Refereed]
Taisuke Tomita, Nobumasa Takasugi, Tomoki Sasaki, Satoko Osawa, Satoshi Yokoshima, Tohru Fukuyama, Virginia Lee, John Trojanowski, Takeshi Iwatsubo
Alzheimer's & Dementia   7(4) S411   Jul 2011   [Refereed]
Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience   31(18) 6850-6857   May 2011   [Refereed]
Tomita T, Wong PC
Alzheimer's research & therapy   3(2) 7   Mar 2011   [Refereed]
Tomita T.
Nihon rinsho. Japanese journal of clinical medicine   69 Suppl 8 98-102   2011   [Refereed]
Tomita T, Sakurai Y, Ishibashi S, Maru Y.
Oncogene   30(31) 3429-3439   2011   [Refereed]
Asai M, Iwata N, Tomita T, Iwatsubo T, Ishiura S, Saido TC, Maruyama K
Journal of neuroscience research   88(16) 3588-3597   Dec 2010   [Refereed]
Takagi S, Tominaga A, Sato C, Tomita T, Iwatsubo T
The Journal of neuroscience : the official journal of the Society for Neuroscience   30(47) 15943-15950   Nov 2010   [Refereed]
Morohashi Y, Tomita T, Iwatsubo T
Nihon rinsho. Japanese journal of clinical medicine   68(10) 1906-1910   Oct 2010   [Refereed]
Kurosumi M, Nishio Y, Osawa S, Kobayashi H, Iwatsubo T, Tomita T, Miyachi H
Bioorganic & medicinal chemistry letters   20(17) 5282-5285   Sep 2010   [Refereed]
Fukumoto H, Takahashi H, Tarui N, Matsui J, Tomita T, Hirode M, Sagayama M, Maeda R, Kawamoto M, Hirai K, Terauchi J, Sakura Y, Kakihana M, Kato K, Iwatsubo T, Miyamoto M
The Journal of neuroscience : the official journal of the Society for Neuroscience   30(33) 11157-11166   Aug 2010   [Refereed]
Taisuke Tomita
Alzheimer's & Dementia   6(4) S93   Jul 2010   [Refereed]
Watanabe N, Image Image II, Takagi S, Image Image II, Tominaga A, Image Image I, Tomita T, Image Image II, Iwatsubo T, Image Image I
The Journal of biological chemistry   285(26) 19738-19746   Jun 2010   [Refereed]
Morohashi Y, Tomita T, Iwatsubo T.
Nippon rinsho. Japanese journal of clinical medicine   68(10) 1906-1910   2010   [Refereed]
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T
Bioorganic and Medicinal Chemistry Letters   20(5) 1798-1799   2010   [Refereed]
Yokoshima S, Abe Y, Watanabe N, Kita Y, Kan T, Iwatsubo T, Tomita T, Fukuyama T
Bioorganic & medicinal chemistry letters   19(24) 6869-6871   Dec 2009   [Refereed]
Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S
Cancer science   100(12) 2444-2450   Dec 2009   [Refereed]
Tomita T
Rinsho shinkeigaku = Clinical neurology   49(11) 845-847   Nov 2009   [Refereed]
Hayashi I, Takatori S, Urano Y, Iwanari H, Isoo N, Osawa S, Fukuda MA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T
The Journal of biological chemistry   284(41) 27838-27847   Oct 2009   [Refereed]
Tomita T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(13) 1747-1753   Oct 2009   [Refereed]
Tomita T
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(12 Suppl) 1684-1689   Sep 2009   [Refereed]
Hiroyuki Miyashita, Yuusuke Maruyama, Toshihiko Ogura, Kazuhiro Mio, Takeshi Iwatsubo, Taisuke Tomita, Chikara Sato
Alzheimer's & Dementia   5(4) P317   Jul 2009   [Refereed]
Taisuke Tomita, Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Tatsuhiko Kodama, Takao Hamakubo, Takeshi Iwatsubo
Alzheimer's & Dementia   5(4) P87   Jul 2009   [Refereed]
Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T
Journal of the American Chemical Society   131(21) 7353-7359   Jun 2009   [Refereed]
Tomita T
Expert review of neurotherapeutics   9(5) 661-679   May 2009   [Refereed]
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G
The Journal of biological chemistry   284(3) 1373-1384   Jan 2009   [Refereed]
Tomita T.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(13) 1747-1753   2009   [Refereed]
Tomita T.
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   54(12 Suppl) 1684-1689   2009   [Refereed]
Tomita T
Rinsho shinkeigaku = Clinical neurology   48(11) 907-909   Nov 2008   [Refereed]

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(S))
Project Year: 2007 - 2011    Investigator(s): Taisuke TOMITA
γ-Secretase is an intramembrane protease that is responsible for the generation of amyloid-βpeptide linked to the pathogenesis of Alzheimer disease. Thus, modulation ofγ-secretase activity is a plausible therapeutics for Alzheimer disease. We have...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2005 - 2007    Investigator(s): Taisuke TOMITA
Several lines of evidence suggest that aggregation and deposition of amyloid-β peptide (Aβ) are involved in the pathogenesis of Alzheimer's dipease, that is the most common cause of dementia with aging. Thus, γ-secretase, that is a pivotal enzyme ...