KIHARA YASUKI

J-GLOBAL         Last updated: Jul 17, 2019 at 15:43
 
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Name
KIHARA YASUKI
E-mail
ykiharahiroshima-u.ac.jp
Affiliation
Hiroshima University
Degree
Doctor of Philosophy in Medical Science(Kyoto University)

Research Areas

 
 

Published Papers

 
Maruhashi T, Kihara Y, Higashi Y
Journal of atherosclerosis and thrombosis      Jul 2019   [Refereed]
Nitta K, Kurisu S, Erasta R, Sumimoto Y, Ikenaga H, Ishibashi K, Fukuda Y, Kihara Y
Heart and vessels      Jul 2019   [Refereed]
Maruhashi T, Amioka M, Kishimoto S, Ikenaga H, Oki K, Ishida M, Kihara Y, Higashi Y
Internal medicine (Tokyo, Japan)      Jul 2019   [Refereed]
Dai Kazuoki, Suruga Kazuki, Nakano Takayuki, Takemoto Hajime, Hashimoto Yu, Tomomori Syunsuke, Higaki Tadanao, Oi Kuniomi, Kawase Tomoharu, Nakama Yasuharu, Suenari Kazuyoshi, Nishioka Kenji, Otsuka Masaya, Masaoka Yoshiko, Shiode Nobuo, Kihara Yasuki
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   73(9) 111   Mar 2019   [Refereed]
Matsui S, Maruhashi T, Kihara Y, Higashi Y
European heart journal      Dec 2018   [Refereed]
Yamamoto Hideya, Kitagawa Toshiro, Kunita Eiji, Utsunomiya Hiroto, Senoo Atsuhiro, Nakamoto Yumiko, Kihara Yasuki
CIRCULATION JOURNAL   82(9) 2342-+   Sep 2018   [Refereed]
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Hashimoto, Haruki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Mohamad; Kishimoto, Shinji; Nakashima, Ayumu; Noma, Kensuke; Kawaguchi, Tomohiro; Matsumoto, Takeo; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   265 24-29   Aug 2018   [Refereed]
Background: Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endo...
Sasaki, Nobuo; Yamamoto, Hideya; Ozono, Ryoji; Fujiwara, Saeko; Kihara, Yasuki
CIRCULATION JOURNAL   82(8) 2049-2054   Aug 2018   [Refereed]
Background: N-Terminal pro B-type natriuretic peptide (NT-proBNP) is widely used as a marker of ventricular dysfunction. However, data regarding the association of NT-proBNP with blood pressure (BP) and pulse pressure (PP) in the elderly populatio...
Senoo, Atsuhiro; Kitagawa, Toshiro; Torimaki, Shinya; Yamamoto, Hideya; Sentani, Kazuhiro; Takahashi, Shinya; Kubo, Yumiko; Yasui, Wataru; Sueda, Taijiro; Kihara, Yasuki
HEART AND VESSELS   33(8) 827-836   Aug 2018   [Refereed]
The means by which epicardial adipose tissue (EAT) could influence coronary plaque progression biologically remain unclear. We investigated the association between the histological findings of EAT and coronary plaque characteristics assessed by co...
Noma Kensuke, Kihara Yasuki, Higashi Yukihito
CIRCULATION JOURNAL   82(8) 1996-1998   Aug 2018   [Refereed]
Kurisu, Satoshi; Nitta, Kazuhiro; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki
ANNALS OF NUCLEAR MEDICINE   32(6) 404-409   Jul 2018   [Refereed]
Current electrocardiographic (ECG) machines report various variables including frontal QRS axis automatically. We tested the hypothesis that QRS axis is associated with left ventricular (LV) diastolic parameters derived from ECG-gated myocardial p...
Kurisu, Satoshi; Nitta, Kazuhiro; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki
NUCLEAR MEDICINE COMMUNICATIONS   39(7) 597-600   Jul 2018   [Refereed]
BackgroundMyocardial perfusion single-photon emission computed tomography (SPECT) with thallium (Tl)-201 is an established modality for evaluating myocardial ischemia. We assessed the effects of atrial fibrillation (AF) on the myocardial washout r...
Sumimoto, Yoji; Kurisu, Satoshi; Hitta, Kazuhiro; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Nakano, Yukiko; Kihara, Yasuki
HEART AND VESSELS   33(7) 786-792   Jul 2018   [Refereed]
Atrial fibrillation (AF) is the most common arrhythmia, characterized by a lack of atrial contraction and an irregular ventricular rhythm. We assessed the effect of fibrillatory wave amplitude on coronary blood flow in patients with AF using the t...
Maruhashi, Tatsuya; Kihara, Yasuki; Higashi, Yukihito
JOURNAL OF HYPERTENSION   36(7) 1460-1467   Jul 2018   [Refereed]
Vascular response to exogenously administered nitroglycerine, an index of endothelium-independent vasodilation, has been used as a control test for the assessment of endothelium-dependent vasodilation (endothelial function) in humans. However, evi...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Oda, Nozomu; Kishimoto, Shinji; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Hida, Eisuke; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Yusoff, Farina Mohamad; Noma, Kensuke; Kuwahara, Yoshitaka; Matsubara, Akio; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   261 196-203   Jun 2018   [Refereed]
Background: Lower urinary tract symptoms (LUTS) is not only common symptoms in elderly men and women but also risk of future cardiovascular events. The purpose of this study was to evaluate the relationships of vascular function and structure with...
Kishimoto, Shinji; Matsumoto, Takeshi; Maruhashi, Tatsuya; Iwamoto, Yumiko; Kajikawa, Masato; Oda, Nozomu; Matsui, Shogo; Hashimoto, Haruki; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Nakashima, Ayumu; Noma, Kensuke; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   260 178-183   Jun 2018   [Refereed]
Background: Although reactive hyperemia-peripheral arterial tonometry (RH-PAT) is widely used for assessment of endothelial function, RH index (RHI) cannot be measured in some cases when pulse wave amplitude (PWA) is very low. Decrease in PWA is m...
Harima, Ayako; Sairaku, Akinori; Inoue, Ichiro; Nishioka, Kenji; Oka, Toshiharu; Nakama, Yasuharu; Dai, Kazuoki; Ohi, Kuniomi; Hashimoto, Haruki; Kihara, Yasuki
JOURNAL OF INTERVENTIONAL CARDIOLOGY   31(3) 284-292   Jun 2018   [Refereed]
ObjectivesWe aimed to test a novel stent-less revascularization strategy using a combination of excimer laser coronary angioplasty (ELCA) and drug-coated balloon (DCB) for patients with acute coronary syndrome (ACS). BackgroundPercutaneous coronar...
Sairaku, Akinori; Nakano, Yukiko; Shiode, Nobuo; Suenari, Kazuyoshi; Oda, Nozomu; Ono, Koichi; Kihara, Yasuki
CARDIOVASCULAR THERAPEUTICS   36(3) e12325   Jun 2018   [Refereed]
Aim: The bisoprolol transdermal patch is a newly developed-blocker designed to deliver its pharmaceutical ingredient through the skin surface. We aimed to compare the bisoprolol transdermal patch and bisoprolol fumarate tablet using the heart rate...
Kurisu, Satoshi; Nitta, Kazuhiro; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki
HEART AND VESSELS   33(6) 651-656   Jun 2018   [Refereed]
Aortic tortuosity is often found on chest radiograph, especially in aged patients. We tested the hypothesis that aortic tortuosity was associated with LV diastolic parameters derived from gated SPECT in patients with normal myocardial perfusion. O...
Watanabe, Ryo; Sairaku, Akinori; Yoshida, Yukihiko; Nanasato, Mamoru; Kamiya, Hiroki; Suzuki, Hirohiko; Ogura, Yasuhiro; Aoyama, Yutaka; Maeda, Mayuho; Ando, Monami; Eguchi, Shunsuke; Inden, Yasuya; Kihara, Yasuki; Murohara, Toyoaki
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY   41(4) 376-382   Apr 2018   [Refereed]
BackgroundCryoballoon (CB) applications to pulmonary veins (PVs) can cause stenosis just as radiofrequency (RF) energy deliveries. The goal of the present study was to clarify whether or not there was any difference in the extent of acute or chron...
Iwamoto, Yumiko; Maruhashi, Tatsuya; Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   254 284-290   Mar 2018   [Refereed]
Backgrounds: Nitroglycerine-induced vasodilation (NID) is usually assessed as a control test for flow-mediated vasodilation (FMD). However, NID per se is impaired in patients with high cardiovascular risk. The purpose of this study was to investig...
Sasaki, Nobuo; Fujiwara, Saeko; Yamashita, Hidehisa; Ozono, Ryoji; Monzen, Yuko; Teramen, Kazushi; Kihara, Yasuki
OBESITY RESEARCH & CLINICAL PRACTICE   12(2) 187-194   Mar 2018   [Refereed]
Objective: The objective of this study was to investigate the association between obesity and sleep habits, including bedtime, wake-up time, and sleep duration variability over a week. Methods: We analyzed 9289 participants in this study. Followin...
Ikenaga, Hiroki; Kurisu, Satoshi; Nakao, Tsukasa; Kono, Shingo; Sumimoto, Yoji; Watanabe, Noriaki; Shimonaga, Takashi; Higaki, Tadanao; Iwasaki, Toshitaka; Mitsuba, Naoya; Ishibashi, Ken; Dohi, Yoshihiro; Fukuda, Yukihiro; Kihara, Yasuki
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING   19(3) 310-318   Mar 2018   [Refereed]
Aims This study was undertaken to assess the association between plaque features at culprit lesions assessed by frequency-domain optical coherence tomography (FD-OCT) and impaired microvascular perfusion estimated by intracoronary electrocardiogra...
Kitagawa, Toshiro; Yamamoto, Hideya; Hattori, Takuya; Sentani, Kazuhiro; Takahashi, Shinya; Senoo, Atsuhiro; Kubo, Yumiko; Yasui, Wataru; Sueda, Taijiro; Kihara, Yasuki
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS   25(3) 269-280   Mar 2018   [Refereed]
Aims: Tumor necrosis factor (TNF)-alpha reportedly has key pro-inflammatory properties in both atherosclerosis and adipocytes. To further investigate the biologic impact of epicardial adipose tissue (EAT) on coronary atherosclerosis, we evaluated ...
Fukuda, Yukihiro; Okamoto, Mitsunori; Tomomori, Shunsuke; Matsumura, Hiroya; Tokuyama, Takehito; Nakano, Yukiko; Kihara, Yasuki
INTERNAL MEDICINE   57(5) 633-640   Mar 2018   [Refereed]
Objective The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that can be used to detect atrial inflammatory changes, which may contribute to a reduced left atrial (LA) function and thrombosis. Our study aimed to determine whether o...
Tatsugami, Fuminari; Higaki, Toru; Sakane, Hiroaki; Nakamura, Yuko; Iida, Makoto; Baba, Yasutaka; Fujioka, Chikako; Senoo, Atsuhiro; Kitagawa, Toshiro; Yamamoto, Hideya; Kihara, Yasuki; Awai, Kazuo
BRITISH JOURNAL OF RADIOLOGY   91(1082) 20170598   Feb 2018   [Refereed]
Objective: The purpose of our study was to compare the diagnostic performance of coronary CT angiography (CTA) subjected to model-based iterative reconstruction (IR) or hybrid IR to rule out coronary in-stent restenosis. Methods: We enrolled 16 pa...
Kitagawa, Toshiro; Oda, Noboru; Mizukawa, Mariko; Hidaka, Takayuki; Naka, Makiko; Nakayama, Susumu; Kihara, Yasuki
PLOS ONE   13(1) e0190979   Jan 2018   [Refereed]
Background Patients with heart failure (HF) are reportedly at high risk for 'all-cause' re-hospitalization. A biomarker for HF, N-terminal pro-brain natriuretic peptide (NT-proBNP), enables to simply detect patients with possible HF (pHF). We exam...
Maruhashi, Tatsuya; Iwamoto, Yumiko; Kajikawa, Masato; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Hida, Eisuke; Higashi, Yukihito
JOURNAL OF THE AMERICAN HEART ASSOCIATION   7(1)    Jan 2018   [Refereed]
Background-Flow-mediated vasodilation (FMD) of the brachial artery has been used for the assessment of endothelial function. Considering the mechanism underlying the vasodilatory response of the brachial artery to reactive hyperemia, hyperemic she...
Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
ATHEROSCLEROSIS   268 92-98   Jan 2018   [Refereed]
Background and aims: Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovas...
Sasaki, Nobuo; Ozono, Ryoji; Fujiwara, Saeko; Maeda, Ryo; Kihara, Yasuki
INTERNATIONAL JOURNAL OF HYPERTENSION   2018 5126270   2018   [Refereed]
We evaluated data from 10,088 participants without cardiovascular disease (CVD) who underwent 75 g oral glucose tolerance tests and had more than four visits during the first 5 years following the test to investigate the association between impair...
Clinical Benefit of Minimally-Interrupted Dabigatran versus Uninterrupted Warfarin for Catheter Ablation of Atrial Fibrillation: A Prospective Randomized Multicenter Trial
CIRCULATION   136(24) E450   Dec 2017   [Refereed]
Matsumura, Hiroya; Nakano, Yukiko; Ochi, Hidenori; Onohara, Yuko; Sairaku, Akinori; Tokuyama, Takehito; Tomomori, Shunsuke; Motoda, Chikaaki; Amioka, Michitaka; Hironobe, Naoya; Toshishige, Masaaki; Takahashi, Shinya; Imai, Katsuhiko; Sueda, Taijiro; Chayama, Kazuaki; Kihara, Yasuki
JOURNAL OF BIOMEDICAL SCIENCE   24(1) 91   Dec 2017   [Refereed]
Background: A common SCN5A polymorphism H558R (c.1673 A > G, rs1805124) improves sodium channel activity in mutated channels and known to be a genetic modifier of Brugada syndrome patients (BrS). We investigated clinical manifestations and underly...
Tanaka, Haruki; Takahashi, Teruyuki; Ohashi, Norihiko; Tanaka, Koichi; Okada, Takenori; Kihara, Yasuki
MEDICINE   96(51) e9275   Dec 2017   [Refereed]
The aim of this study was to clarify the predictive value of fractional flow reserve (FFR) determined by myocardial perfusion imaging (MPI) using thallium (Tl)-201 IQ-SPECT without and with computed tomography-based attenuation correction (CT-AC) ...
Endothelial Function Measured by Enclosed Zone Flow-mediated Vasodilation Predicts Cardiovascular Events
Kajikawa Masato, Morimoto Haruka, Oda Nozomu, Idei Naomi, Hirano Harutoyo, Maruhashi Tatsuya, Kishimoto Shinji, Matsui Shogo, Hidaka Takayuki, Yusoff Farina B., Kihara Yasuki, Noma Kensuke, Nakashima Ayumu, Ukawa Teiji, Tsuji Toshio, Higashi Yukihito
CIRCULATION   136    Nov 2017   [Refereed]
Different Effect of Percutaneous Edge-to-Edge Repair on Mitral Valve Geometry Between Central and Eccentric Functional Mitral Regurgitation
Utsunomiya Hiroto, Itabashi Yuji, Kobayashi Sayuki, Nagaura Takafumi, Yamaguchi Satoshi, Hidaka Takayuki, Kihara Yasuki, Kar Sibal, Shiota Takahiro
CIRCULATION   136    Nov 2017   [Refereed]
Increased Epicardial Fat Volume Enhances a Predictive Value of Long-term Coronary Morbidity in Non-obstructive Coronary Artery Disease
Senoo Atsuhiro, Yamamoto Hideya, Nakamoto Yumiko, Kitagawa Toshiro, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
Impaired Endothelial Function in Patients With Hypertension Receiving Antihypertensive Drug Treatment Regardless of Achieved Blood Pressure Level:-FMD-J Study
Maruhashi Tatsuya, Higashi Yukihito, Iwamoto Yumiko, Kajikawa Masato, Kishimoto Shinji, Matsui Shogo, Hashimoto Haruki, Yusoff Farina B., Hidaka Takayuki, Nakashima Ayumu, Noma Kensuke, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
F-18-Sodium Fluoride Activity is Related to Computed Tomography-based High-risk Coronary Atherosclerosis and Predicts Short-term Coronary Events
Kitagawa Toshiro, Yamamoto Hideya, Toshimitsu Shinya, Sasaki Ko, Senoo Atsuhiro, Nakamoto Yumiko, Hirokawa Yutaka, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
A Common SCN10A Variant May Promote DNA Methylation of SCN5A Promoter and Decrease SCN5A Expression in Brugada Syndrome Patients Without SCN5A Exonic Mutation
Okamura Sho, Nakano Yukiko, Ookubo Yousaku, Hironobe Naoya, Amioka Mititaka, Tomomori Shunsuke, Motoda Tikaaki, Matumura Seiya, Sairaku Akinori, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
Vascular Function is Impaired in Subjects With Decreased Circulating Level of Pigment Epithelium-derived Factor
Kajikawa Masato, Higashi Yukihito, Maruhashi Tatsuya, Kishimoto Shinji, Matsui Shogo, Yusoff Farina B., Hidaka Takayuki, Noma Kensuke, Nakashima Ayumu, Matsui Takanori, Yamagishi Sho-ichi, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
Slow Down, You Eat Too Fast: Fast Eating Associate With Obesity and Future Prevalence of Metabolic Syndrome
Yamaji Takayuki, Mikami Shinsuke, Kobatake Hiroshi, Tanaka Koichi, Higashi Yukihito, Kihara Yasuki
CIRCULATION   136    Nov 2017   [Refereed]
Effect of Coffee With a High Content of Chlorogenic Acids and Low Content of Hydroxyhydroquinone on Postprandial Endothelial Dysfunction
Kajikawa Masato, Maruhashi Tatsuya, Hidaka Takayuki, Nakano Yukiko, Kurisu Satoshi, Matsumoto Takeshi, Iwamoto Yumiko, Iwamoto Yumiko, Kishimoto Shinji, Matsui Shogo, Hashimoto Haruki, Yusoff Farina B., Kihara Yasuki, Noma Kensuke, Nakashima Ayumu, Watanabe Takuya, Tone Hiroshi, Hibi Masanobu, Osaki Noriko, Katsuragi Yoshihisa, Higashi Yukihito
CIRCULATION   136    Nov 2017   [Refereed]
Short Term Colchicine Treatment Improves Endothelial Function in Patients With Cardiovascular Disease
Kajikawa Masato, Kurisu Satoshi, Maruhashi Tatsuya, Hidaka Takayuki, Iwamoto Yumiko, Kishimoto Shinji, Matsui Shogo, Hashimoto Haruki, Yusoff Farina B., Kihara Yasuki, Noma Kensuke, Nakashima Ayumu, Matsushita Akiko, Tomiyama Hirofumi, Ueda Shinichiro, Higashi Yukihito
CIRCULATION   136    Nov 2017   [Refereed]
Kurisu, Satoshi; Sumimoto, Yoji; Ikenaga, Hiroki; Ishibashi, Ken; Fukuda, Yukihiro; Kihara, Yasuki
ANNALS OF NUCLEAR MEDICINE   31(9) 703-708   Nov 2017   [Refereed]
Myocardial perfusion single photon emission computed tomography (SPECT) is often performed even in patients with chronic kidney disease (CKD). We assessed the effects of CKD on myocardial washout rate (WR) of thallium (Tl)-201 in patients with nor...
Higashi, Akifumi; Dohi, Yoshihiro; Yamabe, Sayuri; Kinoshita, Hiroki; Sada, Yoshiharu; Kitagawa, Toshiro; Hidaka, Takayuki; Kurisu, Satoshi; Yamamoto, Hideya; Yasunobu, Yuji; Kihara, Yasuki
HEART AND VESSELS   32(11) 1350-1357   Nov 2017   [Refereed]
Cardiopulmonary exercise testing (CPET) is useful for the evaluation of patients with suspected or confirmed pulmonary hypertension (PH). End-tidal carbon dioxide pressure (PETCO2) during exercise is reduced with elevated pulmonary artery pressure...
Sasaki, Nobuo; Fujiwara, Saeko; Ozono, Ryoji; Yamashita, Hidehisa; Kihara, Yasuki
MEDICINE   96(42) e8272   Oct 2017   [Refereed]
This study aimed to investigate the association between sleeping pill use and hypertension or blood pressure (BP) via a cross-sectional analysis.A total of 11,225 subjects (5875 men and 5350 women) underwent health examinations. We compared the pr...
Maruhashi, Tatsuya; Soga, Junko; Fujimura, Noritaka; Idei, Naomi; Mikami, Shinsuke; Iwamoto, Yumiko; Iwamoto, Akimichi; Kajikawa, Masato; Matsumoto, Takeshi; Oda, Nozomu; Kishimoto, Shinji; Matsui, Shogo; Hashimoto, Haruki; Aibara, Yoshiki; Yusoff, Farina Binti Mohamad; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Noma, Kensuke; Nakashima, Ayumu; Goto, Chikara; Tomiyama, Hirofumi; Takase, Bonpei; Kohro, Takahide; Suzuki, Toru; Ishizu, Tomoko; Ueda, Shinichiro; Yamazaki, Tsutomu; Furumoto, Tomoo; Kario, Kazuomi; Inoue, Teruo; Koba, Shinji; Watanabe, Kentaro; Takemoto, Yasuhiko; Hano, Takuzo; Sata, Masataka; Ishibashi, Yutaka; Node, Koichi; Maemura, Koji; Ohya, Yusuke; Furukawa, Taiji; Ito, Hiroshi; Ikeda, Hisao; Yamashina, Akira; Higashi, Yukihito
HYPERTENSION   70(4) 790-+   Oct 2017   [Refereed]
Hypertension is associated with endothelial dysfunction. Blood pressure significantly correlates with endothelial function in antihypertensive drug-naive subjects. The purpose of this study was to determine whether treatment status affects the rel...
Yamamoto, Hideya; Sugiyama, Eiji; Serikawa, Masahiro; Tatsugami, Fuminari; Yokozaki, Michiya; Kitagawa, Toshiro; Senoo, Atsushi; Nakamoto, Yumiko Kubo; Awai, Kazuo; Chayama, Kazuaki; Kihara, Yasuki
HEART AND VESSELS   32(10) 1176-1185   Oct 2017   [Refereed]
Vascular and/or perivascular involvements of sclerotic inflammation (perivasculitis) are a complication of immunoglobulin G4-related disease (IgG4-RD). We sought to examine clinical manifestations of perivasculitis by computed tomography (CT) in p...
Tanabe, Nobuhiro; Ikeda, Satoshi; Tahara, Nobuhiro; Fukuda, Keiichi; Hatano, Masaru; Ito, Hiroshi; Nakayama, Tomotaka; Anzai, Toshihisa; Hashimoto, Akiyoshi; Inoue, Teruo; Kajinami, Kouji; Kihara, Yasuki; Kinoshita, Hideyuki; Kuwahara, Koichiro; Murohara, Toyoaki; Okazaki, Osamu; Sakai, Satoshi; Satoh, Toru; Takeda, Yutaka; Takeishi, Yasuchika; Taniguchi, Mitsugu; Watanabe, Hiroshi; Yamamoto, Takeshi; Yamauchi-Takihara, Keiko; Yoshioka, Koichiro; Sasayama, Shigetake
CIRCULATION JOURNAL   81(9) 1360-1367   Sep 2017   [Refereed]
Background: Selexipag is an orally available prostacyclin receptor (IP receptor) agonist with a non-prostanoid structure. In this open-label Phase II trial, the efficacy and safety of selexipag in Japanese patients with pulmonary arterial hyperten...
Kurisu, Satoshi; Sumimoto, Yoji; Ikenaga, Hiroki; Watanabe, Noriaki; Ishibashi, Ken; Dohi, Yoshihiro; Fukuda, Yukihiro; Kihara, Yasuki
HEART AND VESSELS   32(9) 1062-1066   Sep 2017   [Refereed]
Myocardial perfusion single-photon emission computed tomography (SPECT) is often performed even in patients with suspected coronary artery disease complicated by anemia. We assessed the effects of hemoglobin level on myocardial washout rate of Tha...
Matsui, Shogo; Kajikawa, Masato; Hida, Eisuke; Maruhashi, Tatsuya; Iwamoto, Yumiko; Iwamoto, Akimichi; Oda, Nozomu; Kishimoto, Shinji; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Yusoff, Farina Binti Mohamad; Noma, Kensuke; Higashi, Yukihito
SCIENTIFIC REPORTS   7(1) 8422   Aug 2017   [Refereed]
We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-m...
Matsui, Shogo; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Iwamoto, Akimichi; Oda, Nozomu; Kishimoto, Shinji; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Taguchi, Akira; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   241 30-34   Aug 2017   [Refereed]
Background: Periodontal disease is associated with endothelial dysfunction, leading to cardiovascular disease. The effect of detailed tooth brushing behavior, not only frequency but also duration of tooth brushing, on endothelial function is uncle...
Ikenaga, Hiroki; Nakano, Yukiko; Oda, Noboru; Suenari, Kazuyoshi; Sairaku, Akinori; Tokuyama, Takehito; Kawazoe, Hiroshi; Matsumura, Hiroya; Tomomori, Shunsuke; Kihara, Yasuki
JOURNAL OF ARRHYTHMIA   33(4) 256-261   Aug 2017   [Refereed]
Background: Radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) refractory to medical therapy remains controversial in patients with hypertrophic cardiomyopathy (HCM); the acute effects on the direct left atrial (LA) pressure are ...
Kitagawa, Toshiro; Yamamoto, Hideya; Toshimitsu, Shinya; Sasaki, Ko; Senoo, Atsuhiro; Kubo, Yumiko; Tatsugami, Fuminari; Awai, Kazuo; Hirokawa, Yutaka; Kihara, Yasuki
ATHEROSCLEROSIS   263 385-392   Aug 2017   [Refereed]
Background and aims: We aimed at evaluating the relation of F-18-sodium fluoride (F-18-NaF) uptake on positron emission tomography (PET) to coronary atherosclerosis detected and assessed by computed tomography (CT). Methods: Thirty-two patients wi...
Tatsugami, Fuminari; Higaki, Toru; Sakane, Hiroaki; Fukumoto, Wataru; Kaichi, Yoko; Lida, Makoto; Baba, Yasutaka; Kiguchi, Masao; Kihara, Yasuki; Tsushima, So; Awai, Kazuo
ACADEMIC RADIOLOGY   24(8) 975-981   Aug 2017   [Refereed]
Rationale and Objectives: This study aims to compare the image quality of coronary artery stent scans on computed tomography images reconstructed with forward projected model based iterative reconstruction solution (FIRST) and adaptive iterative d...
Suenari, Kazuyoshi; Mitsuba, Naoya; Hirao, Hidekazu; Ueda, Hironori; Kihara, Yasuki
CLINICAL CASE REPORTS   5(7) 1162-1166   Jul 2017   [Refereed]
The present case demonstrated a rare situation alternating between a repetitive atrial tachycardia (AT) and ventricular tachycardia (VT). A unique induction mechanism was noted in which the VT was induced after Wenckebach AV node conduction block ...
Kurisu, Satoshi; Sumimoto, Yoji; Ikenaga, Hiroki; Watanabe, Noriaki; Ishibashi, Ken; Dohi, Yoshihiro; Fukuda, Yukihiro; Kihara, Yasuki
HEART AND VESSELS   32(7) 790-795   Jul 2017   [Refereed]
The myocardial perfusion single photon emission computed tomography synchronized with the electrocardiogram (gated SPECT) has been widely used for the assessment of left ventricular (LV) systolic and diastolic functions using Quantitative gated SP...
Oda, Nozomu; Maruhashi, Tatsuya; Kishimoto, Shinji; Kajikawa, Masato; Iwamoto, Yumiko; Iwamoto, Akimichi; Matsui, Shogo; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Hirano, Harutoyo; Higashi, Yukihito
AMERICAN JOURNAL OF CARDIOLOGY   119(12) 1983-1988   Jun 2017   [Refereed]
The presence of an earlobe crease (ELC) may be a simple sign to predict atherosclerosis. We evaluated the relation between ELC and vascular function. We measured flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) and ob...
Sairaku, Akinori; Yoshida, Yukihiko; Nakano, Yukiko; Hirayama, Haruo; Maeda, Mayuho; Hashimoto, Haruki; Kihara, Yasuki
EUROPACE   19(5) 824-830   May 2017   [Refereed]
Aims Sarcoidosis with cardiac involvement is a rare pathological condition, and therefore cardiac resynchronization therapy (CRT) for patients with cardiac sarcoidosis is even further rare. We aimed to clarify the clinical features of patients wit...
Kurisu, Satoshi; Shimonaga, Takashi; Ikenaga, Hiroki; Watanabe, Noriaki; Higaki, Tadanao; Ishibashi, Ken; Dohi, Yoshihiro; Fukuda, Yukihiro; Kihara, Yasuki
HEART AND VESSELS   32(4) 369-375   Apr 2017   [Refereed]
Selvester QRS scoring system has an advantage of being inexpensive and easily accessible for estimating myocardial infarct (MI) size. We assessed the correlation and agreement between QRS score and total perfusion deficit (TPD) calculated by quant...
THE PROGNOSTIC VALUE OF CPET: ASSOCIATION WITH CORONARY ARTERY CALCIUM SCORE
Hakimi Matthew, Kisaka Tomohiko, Sietsema Kathy, Kihara Yasuki, Wasserman Karlman, Budoff Matthew
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY   69(11) 1830   Mar 2017   [Refereed]
Kishimoto, Shinji; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Matsumoto, Takeshi; Iwamoto, Akimichi; Oda, Nozomu; Matsui, Shogo; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   231 181-187   Mar 2017   [Refereed]
Background: Endothelial dysfunction and abnormal vascular structure may be involved in the pathogenesis of chronic heart failure (HF). The purpose of this study was to evaluate simultaneously vascular function and vascular structure in patients wi...
Oda, Nozomu; Kajikawa, Masato; Maruhashi, Tatsuya; Iwamoto, Yumiko; Kishimoto, Shinji; Matsui, Shogo; Hidaka, Takayuki; Kihara, Yasuki; Chayama, Kazuaki; Goto, Chikara; Aibara, Yoshiki; Nakashima, Ayumu; Noma, Kensuke; Tomiyama, Hirofumi; Takase, Bonpei; Yamashina, Akira; Higashi, Yukihito
INTERNATIONAL JOURNAL OF CARDIOLOGY   230 523-528   Mar 2017   [Refereed]
Background: Heavy drinking should be a predictor of endothelial dysfunction. However, there is little information on the effects of light to moderate alcohol consumption on endothelial function. The purpose of this study was to estimate the effect...
Coronary Artery Stent Evaluation with Model-based Iterative Reconstruction at Coronary CT Angiography
Tatsugami F, Higaki T, Sakane H, Fukumoto W, Kaichi Y, Iida M, Baba Y, Kiguchi M, Kihara Y, Tsushima S, Awai K
Acad Radiol      Feb 2017   [Refereed]
Inoue, Noriko; Kawakami, Hideshi; Yamamoto, Hideya; Ito, Chikako; Fujiwara, Saeko; Sasaki, Hideo; Kihara, Yasuki
HYPERTENSION RESEARCH   40(2) 207-211   Feb 2017   [Refereed]
The second derivative of the digital photoplethysmogram (SDPTG) is an indicator of arterial stiffness. The ratio of the height of the d wave to the a wave of the SDPTG (d/a) is associated with functional peripheral vascular tension and represents ...
Kajikawa M, Oda N, Kishimoto S, Maruhashi T, Iwamoto Y, Iwamoto A, Matsui S, Aibara Y, Mohamad Yusoff FB, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Taguchi A, Higashi Y
Circ J   81(6) 862-+   Feb 2017   [Refereed]
Background: Osteoporosis and cardiovascular disease are major public health problems. A number of clinical studies have shown a link between osteoporosis and cardiovascular disease, but there is no information on the associations of risk of osteop...
Masada K, Hidaka T, Harada Y, Kinoshita M, Itakura K, Higashi A, Utsunomiya H, Kihara Y
Echocardiography   34(2) 217-225   Feb 2017   [Refereed]
Background: Nearly half of patients with heart failure have normal left ventricular ejection fraction (LVEF), but their prognosis is no better than those with reduced LVEF. Although peak oxygen consumption (VO2) is an independent predictor of mort...
Kurisu S, Higaki T, Sumimoto Y, Ikenaga H, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
Ann Nucl Med   31(3) 245-249   Feb 2017   [Refereed]
Background Aortic knob width on chest radiography represents the extent of aortic dialation and tortuosity of the aortic arch. We tested the hypothesis that aortic knob width reflected left ventricular (LV) diastolic function assessed by gated myo...
Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction
Kishimoto S, Kajikawa M, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Higashi Y
Int J Cardiol      Jan 2017   [Refereed]
Suenari, Kazuyoshi; Chao, Tze-Fan; Liu, Chia-Jen; Kihara, Yasuki; Chen, Tzeng-Ji; Chen, Shih-Ann
MEDICINE   96(1) e5597   Jan 2017   [Refereed]
The HATCH score (hypertension < 1 point>, age > 75 years < 1 point>, stroke or transient ischemic attack < 2 points>, chronic obstructive pulmonary disease < 1 point>, and heart failure < 2 points>) was reported to be useful for predicting the pro...
Watanabe, Noriaki; Kurisu, Satoshi; Sumimoto, Yoji; Ikenaga, Hiroki; Shimonaga, Takashi; Higaki, Tadanao; Tatsugami, Fuminari; Ishibashi, Ken; Kitagawa, Toshiro; Dohi, Yoshihiro; Fukuda, Yukihiro; Yamamoto, Hideya; Awai, Kazuo; Kihara, Yasuki
CLINICAL AND EXPERIMENTAL HYPERTENSION   39(4) 355-360   2017   [Refereed]
Background: The augmentation index (AI) obtained from applanation tonometry of the radial artery is technically the easiest and quickest of available methods for assessing arterial stiffness. We tested the hypothesis that the radial AI is associat...
A Novel Approach to Tailor Heparin Dosage During Ablation of Atrial Fibrillation: An Assessment of Sensitivity to Unfractionated Heparin
Sairaku Akinori, Nakano Yukiko, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Sinus Node Recovery Time and Minor Allele of ZFHX3 SNP Were Independent Predictors of Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Tomomori Sunsuke, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Common SCN5A Polymorphism H558R Modifies Clinical Phenotype of Brugada Syndrome by Modulating DNA Methylation of SCN5A Promoters
Matsumura Hiroya, Nakano Yukiko, Sairaku Akinori, Tokuyama Takehito, Tomomori Shunsuke, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Common Genetic Variant Within SCN10A Modulates DNA Methylation of SCN5A Promoters
Hironobe Naoya, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Tomomori Shunsuke, Amioka Michitaka, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries
Maruhashi Tatsuya, Higashi Yukihito, Kajikawa Masato, Nakashima Ayumu, Iwamoto Yumiko, Iwamoto Akimichi, Oda Nozomu, Kishimoto Shinji, Matsui Shogo, Higaki Tadanao, Shimonaga Takashi, Watanabe Noriaki, Ikenaga Hiroki, Hidaka Takayuki, Aibara Yoshiki, Noma Kensuke, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Common Variant in Pitx2 Contributes to the Pathogenesis of Paroxysmal Atrial Fibrillation by Impairing Sinus Node Function and Progression of Atrial Remodeling
Tomomori Sunsuke, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
F-18-Sodium Fluoride Positron Emission Tomography for Molecular Imaging of Coronary Atherosclerosis Based on Computed Tomography Analysis
Kitagawa Toshiro, Yamamoto Hideya, Toshimitsu Shinya, Sasaki Ko, Senoo Atsuhiro, Hirokawa Yutaka, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Sinus Node Recovery Time and Minor Allele of ZFHX3 SNP Were Independent Predictors of Atrial Fibrillation Recurrence After Pulmonary Vein Isolation
Tomomori Sunsuke, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Common SCN5A Polymorphism H558R Modifies Clinical Phenotype of Brugada Syndrome by Modulating DNA Methylation of SCN5A Promoters
Matsumura Hiroya, Nakano Yukiko, Sairaku Akinori, Tokuyama Takehito, Tomomori Shunsuke, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Common Genetic Variant Within SCN10A Modulates DNA Methylation of SCN5A Promoters
Hironobe Naoya, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Tomomori Shunsuke, Amioka Michitaka, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries
Maruhashi Tatsuya, Higashi Yukihito, Kajikawa Masato, Nakashima Ayumu, Iwamoto Yumiko, Iwamoto Akimichi, Oda Nozomu, Kishimoto Shinji, Matsui Shogo, Higaki Tadanao, Shimonaga Takashi, Watanabe Noriaki, Ikenaga Hiroki, Hidaka Takayuki, Aibara Yoshiki, Noma Kensuke, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Extracorporeal Cardiopulmonary Resuscitation for Unwitnessed Cardiac Arrest
Kagawa Eisuke, Dote Keigo, Kato Masaya, Sasaki Shota, Oda Noboru, Nakano Yoshinori, Nagai Michiaki, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Common Variant in Pitx2 Contributes to the Pathogenesis of Paroxysmal Atrial Fibrillation by Impairing Sinus Node Function and Progression of Atrial Remodeling
Tomomori Sunsuke, Nakano Yukiko, Tokuyama Takehito, Sairaku Akinori, Matsumura Hiroya, Amioka Michitaka, Hironobe Naoya, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
F-18-Sodium Fluoride Positron Emission Tomography for Molecular Imaging of Coronary Atherosclerosis Based on Computed Tomography Analysis
Kitagawa Toshiro, Yamamoto Hideya, Toshimitsu Shinya, Sasaki Ko, Senoo Atsuhiro, Hirokawa Yutaka, Kihara Yasuki
CIRCULATION   134    Nov 2016   [Refereed]
Amioka Michitaka, Sairaku Akinori, Ochi Tetsuro, Okada Takenori, Asaoku Hideki, Kyo Taiichi, Kihara Yasuki
AMERICAN JOURNAL OF CARDIOLOGY   118(9) 1386-1389   Nov 2016   [Refereed]
[The role of positive air way pressure in heart failure caused by ischemic heart disease].
Hidaka T, Kihara Y
Nihon rinsho. Japanese journal of clinical medicine   74 Suppl 6 423-426   Aug 2016   [Refereed]
Tanaka Haruki, Okada Takenori, Kihara Yasuki
JOURNAL OF THORACIC DISEASE   8(7) 1421-1424   Jul 2016   [Refereed]
McMurray JJ, Krum H, Abraham WT, Dickstein K, Køber LV, Desai AS, Solomon SD, Greenlaw N, Ali MA, Chiang Y, Shao Q, Tarnesby G, Massie BM, ATMOSPHERE Committees Investigators.
The New England journal of medicine   374(16) 1521-1532   Apr 2016   [Refereed]
Progression of arteriosclerosis from a point of view of ROCK: a translational study
Noma Kensuke, Kihara Yasuki, Higashi Yukihito
JOURNAL OF PHARMACOLOGICAL SCIENCES   130(3) S31   Mar 2016   [Refereed]
Extracorporeal Cardiopulmonary Resuscitation for Nonshockable Rhythms
Kagawa Eisuke, Dote Keigo, Kato Masaya, Sasaki Shota, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Influence of Endothelial Function and Rho-Associated Kinase Activity in Patients With Primary Aldosteron ism
Matsumoto Takeshi, Higashi Yukihito, Iwamoto Akimichi, Kajikawa Masato, Oda Nozomu, Maruhashi Tatsuya, Nakashima Ayumu, Noma Kensuke, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Selenium Supplementation Rescues Cardiac Function in Patients With Severe Heart Failure Who are Intractable to Renin-Angiotensin System Inhibitors and beta-blockers
Hiraoka Yuji, Tanabe Masato, Yamazaki Taketoshi, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Vascular Function and Vascular Structure are impaired in Patients With Heart Failure With Preserved Ejection Fraction
Kishimoto Shinji, Higashi Yukihito, Noma Kensuke, Nakashima Ayumu, Hidaka Takayuki, Maruhashi Tatsuya, Kajikawa Masato, Iwamoto Yumiko, Iwamoto Akimichi, Oda Nozomu, Aibara Yoshiki, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Cardiac Resynchronization Therapy for Patients With Cardiac Sarcoidosis
Sairaku Akinori, Yoshida Yukihiko, Nakano Yukiko, Maeda Mayuho, Hashimoto Haruki, Hirayama Haruo, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Significance of Inflammation and Neoangiogenesis of Epicardial Adipose Tissue on Coronary Atherosclerosis Based on Computed Tomography Analysis
Kitagawa Toshiro, Yamamoto Hideya, Tsushima Hiroshi, Senoo Atsuhiro, Sentani Kazuhiro, Yasui Wataru, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry
Kajikawa Masato, Higashi Yukihito, Maruhashi Tatsuya, Iwamoto Yumiko, Iwamoto Akimichi, Oda Nozomu, Kishimoto Shinji, Hidaka Takayuki, Noma Kensuke, Tomiyama Hirofumi, Takase Bonpei, Yamashina Akira, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]
Endothelial Function is Impaired in Relation to Alcohol Consumption in Men in a Large General Population
Oda Nozomu, Higashi Yukihito, Kajikawa Masato, Maruhashi Tatsuya, Iwamoto Akimichi, Kishimoto Shinji, Hidaka Takayuki, Nakashima Ayumu, Noma Kensuke, Tomiyama Hirofumi, Takase Bonpei, Yamashina Akira, Kihara Yasuki
CIRCULATION   132    Nov 2015   [Refereed]

Misc

 
Farina Mohamad Yusoff, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Shinji Kishimoto, Tatsuya Maruhashi, Moniruddin Chowdhury, Kensuke Noma, Ayumu Nakashima, Yasuki Kihara, Taijiro Sueda, Yukihito Higashi
Scientific Reports   9    Dec 2019
© 2019, The Author(s). Critical limb ischemia (CLI) is associated with a high risk of limb amputation. It has been shown that cell therapy is safe and has beneficial effects on ischemic clinical symptoms in patients with CLI. The aim of this study...
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Heart and Vessels   34 971-975   Jun 2019
© 2019, Springer Japan KK, part of Springer Nature. The frontal QRS-T angle is one of the markers of ventricular repolarization. We sought to assess the effects of myocardial perfusion defect on QRS-T angle in patients with prior anterior myocardi...
Tatsuya Maruhashi, Masato Kajikawa, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yoshiki Aibara, Farina M. Yusoff, Takayuki Hidaka, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Yasuki Kihara, Yukihito Higashi
American journal of hypertension   32 640-648   Jun 2019
© American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com. BACKGROUND: Differences between the effects of calcium channel blockers (CCBs) and other antihypertensive drugs on vasc...
Shinji Kishimoto, Yoshihiko Kinoshita, Takeshi Matsumoto, Tatsuya Maruhashi, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Farina Mohamad Yusoff, Ayumu Nakashima, Kensuke Noma, Yukihito Higashi
American journal of hypertension   32 695-702   Jun 2019
© American Journal of Hypertension, Ltd 2019. All rights reserved. For Permissions, please email: journals.permissions@oup.com. BACKGROUND: The effects of dipeptidyl peptidase 4 (DPP-4) inhibitors on blood pressure in patients with diabetes mellit...
北川 知郎, 木原 康樹
総合リハビリテーション   47(6) 539-545   Jun 2019
Kazuhiro Nitta, Satoshi Kurisu, Yumiko Nakamoto, Yoji Sumimoto, Atsuhiro Senoo, Hiroki Ikenaga, Fuminari Tatsugami, Ken Ishibashi, Toshiro Kitagawa, Yukihiro Fukuda, Hideya Yamamoto, Kazuo Awai, Yasuki Kihara
International heart journal   60 554-559   May 2019
It has been shown in several studies that coronary artery calcium (CAC) burden or CAC progression is associated with heart failure. We tested the hypothesis that the extent of CAC is associated with left ventricular (LV) diastolic parameters deriv...
Shinji Kishimoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Farina Mohamad Yusoff, Ayumu Nakashima, Kensuke Noma, James K. Liao, Yukihito Higashi
Journal of hypertension   37 1083-1095   May 2019
OBJECTIVE: Primary aldosteronism is one of the most common cause of secondary hypertension. It is well known that the incidence of cardiovascular events is higher in patients with primary aldosteronism than in patients with essential hypertension....
Masato Kajikawa, Yukihito Higashi, Hirofumi Tomiyama, Tatsuya Maruhashi, Satoshi Kurisu, Yasuki Kihara, Akiko Mutoh, Shin ichiro Ueda
International Journal of Cardiology   281 35-39   Apr 2019
© 2019 Elsevier B.V. Background: Inflammation is associated with endothelial dysfunction and plays an important role in the pathogenesis and development of cardiovascular diseases. It has been shown that colchicine, an anti-inflammatory drug, imp...
Akihiko Nogami, Tomoo Harada, Yukio Sekiguchi, Ryuji Otani, Yukihiko Yoshida, Kentaro Yoshida, Yukiko Nakano, Norihito Nuruki, Shiro Nakahara, Masahiko Goya, Hideki Origasa, Yasuki Kihara, Kenzo Hirao, Kazutaka Aonuma
JAMA network open   2    Apr 2019
Importance: Uninterrupted dabigatran therapy reduces stroke risk in patients with nonvalvular atrial fibrillation (NVAF) undergoing ablation and is associated with a lower bleeding risk than uninterrupted warfarin therapy. Minimally interrupted di...
Masato Kajikawa, Tatsuya Maruhashi, Takayuki Hidaka, Yukiko Nakano, Satoshi Kurisu, Takeshi Matsumoto, Yumiko Iwamoto, Shinji Kishimoto, Shogo Matsui, Yoshiki Aibara, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Takuya Watanabe, Hiroshi Tone, Masanobu Hibi, Noriko Osaki, Yoshihisa Katsuragi, Yukihito Higashi
European Journal of Nutrition   58 989-996   Apr 2019
© 2018, The Author(s). Purpose: The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods: This was a sing...
亜急性心筋梗塞後の虚血性僧帽弁閉鎖不全症による急性心不全に対して外科的治療を行った1例
松井 翔吾, 丸橋 達也, 山路 貴之, 住元 庸二, 池永 寛樹, 石橋 堅, 福田 幸弘, 栗栖 智, 東 幸仁, 木原 康樹, 高橋 信也, 末田 泰二郎
広島医学   72(4) 219-219   Apr 2019
小野 広一, 山本 秀也, 木原 康樹
心電図   39(1) 33-38   Mar 2019
【背景】我が国では年間約5万人が新たに植込み型心臓デバイス(CID)植込み治療を受けているが、死後、火葬時の取り扱いについては一定の見解がない。CIDを取り出さずに火葬可能であれば、安心してCID植込み患者を自宅で看取ることができる。【目的および方法】火葬時のCIDの取り扱いについて、中国地方の現状を調べるため、中国地方5県(鳥取・島根・岡山・広島・山口)の162火葬場の管理者(76事業所)に、火葬時の取り扱いについて電子メール・ファックス・電話で調査した。【結果】摘出なしでは火葬不可が8...
Michitaka Amioka, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Shunsuke Tomomori, Naoya Hironobe, Yousaku Okubo, Sho Okamura, Kazuaki Chayama, Yasuki Kihara
PLoS ONE   14    Mar 2019
© 2019 Amioka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Takayuki Hidaka, Kenji Masada, Yu Harada, Hitoshi Susawa, Mirai Kinoshita, Kiho Itakura, Kanako Izumi, Hiroto Utsunomiya, Yukihito Higashi, Yasuki Kihara
Echocardiography   36 503-511   Mar 2019
© 2019 Wiley Periodicals, Inc. Background: Estimation of left ventricular filling pressure (LVFP) is the essential part of the echocardiographic workup for exercise intolerance. The ratio of the mitral early filling velocity to the left ventricul...
Kazuoki Dai, Kazuki Suruga, Takayuki Nakano, Hajime Takemoto, Yu Hashimoto, Syunsuke Tomomori, Tadanao Higaki, Kuniomi Oi, Tomoharu Kawase, Yasuharu Nakama, Kazuyoshi Suenari, Kenji Nishioka, Masaya Otsuka, Yoshiko Masaoka, Nobuo Shiode, Yasuki Kihara
Coronary Artery Disease   30 150-151   Mar 2019
Coffee with a High Content of Chlorogenic Acids and Low Content of Hydroxyhydroquinone Ameliorates Postprandial Endothelial Dysfunction(和訳中)
梶川 正人, 丸橋 達也, 日高 貴之, 中野 由紀子, 栗栖 智, 岸本 真治, 松井 翔吾, 橋本 東樹, 高永甲 有司, Yusoff Farina Mohamad, 木原 康樹, 野間 玄督, 中島 歩, 渡辺 卓也, 刀禰 寛, 日比 壮信, 大崎 紀子, 桂木 能久, 東 幸仁
日本循環器学会学術集会抄録集   83回 OJ20-2   Mar 2019
Heart Failure in Elderly: A Complex of Unsolved Issues in Japan(和訳中)
木原 康樹
日本循環器学会学術集会抄録集   83回 U40-1 (Keynote Lecture)   Mar 2019
高齢者に対する最適な心不全治療-レジストリから見えてくる課題とは?(The Present Condition and Issues about the Cardiac Rehabilitation for Outpatients with Chronic Heart Failure in Hiroshima Prefecture)
日高 貴之, 北川 知郎, 小田 登, 松田 圭司, 森島 信行, 安信 祐治, 辻山 修司, 磯部 光章, 木原 康樹
日本循環器学会学術集会抄録集   83回 SY05-3   Mar 2019
心房細動発症阻止へ向けた英知の結集(Prediction of Atrial Fibrillation Using Combination of Genetic Risk Score and Clinical Risk Factors)
大久保 陽策, 中野 由紀子, 岡村 祥央, 廣延 直也, 網岡 道孝, 元田 親章, 徳山 丈仁, 木原 康樹
日本循環器学会学術集会抄録集   83回 SY04-5   Mar 2019
【心不全のみきわめ方と適切な管理】 高齢心不全患者の治療に関するステートメント
福田 幸弘, 木原 康樹
臨牀と研究   96(3) 281-284   Mar 2019
左室駆出率の保たれた心不全患者における運動負荷心エコー図指標と最大酸素摂取量との関連についての検討
政田 賢治, 上田 浩徳, 日高 貴之, 宇都宮 裕人, 木原 康樹
広島医学   72(2) 95-95   Feb 2019
Masato Kajikawa, Tatsuya Maruhashi, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Farina Mohamad Yusoff, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Kensuke Noma, Ayumu Nakashima, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
Circulation Journal   83 1064-1071   Jan 2019
© 2019, Japanese Circulation Society. All rights reserved. Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and futu...
Fuminari Tatsugami, Toru Higaki, Yuko Nakamura, Zhou Yu, Jian Zhou, Yujie Lu, Chikako Fujioka, Toshiro Kitagawa, Yasuki Kihara, Makoto Iida, Kazuo Awai
European Radiology      Jan 2019
© 2019, European Society of Radiology. Objectives: The purpose of this study was to compare the image quality of coronary computed tomography angiography (CTA) subjected to deep learning–based image restoration (DLR) method with images subjected t...
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Heart and Vessels      Jan 2019
© 2019, Springer Japan KK, part of Springer Nature. The frontal QRS-T angle on the electrocardiogram has been described as a variable of ventricular repolarization. We evaluated how deep inspiration affected QRS axis, T-wave axis and frontal QRS-T...
Tatsuya Maruhashi, Yoshihiko Kinoshita, Masato Kajikawa, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yuji Takaeko, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Masakazu Takahashi, Yasuki Kihara, Yukihito Higashi
Hypertension Research      Jan 2019
© 2019, The Japanese Society of Hypertension. Hypertension is associated with vascular failure, such as increased arterial stiffness, endothelial dysfunction, and vascular smooth muscle dysfunction. The purpose of this study was to investigate the...
Ikuno Takahashi, John Cologne, Daisuke Haruta, Michiko Yamada, Tetsuya Takahashi, Munechika Misumi, Saeko Fujiwara, Masayasu Matsumoto, Yasuki Kihara, Ayumi Hida, Waka Ohishi
Journal of the American Heart Association   7    Dec 2018
© 2018 The Authors. Background-—Past reports suggested that total-body irradiation at 0.5 to 1.0 Gy could be responsible for atherosclerosis. Peripheral artery disease (PAD) is a manifestation of systematic atherosclerosis. Whether the consequence...
Shunsuke Tomomori, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yousaku Okubo, Shou Okamura, Hiroshi Kawazoe, Yukie Nishiyama, Hidetoshi Tahara, Kazuaki Chayama, Yasuki Kihara
Scientific Reports   8    Dec 2018
© 2018, The Author(s). Genome-wide association studies have reported a strong association of the single nucleotide polymorphism (SNP) rs6817105 (T > C) on chromosome 4q25 with atrial fibrillation (AF), but phenotype alterations conferred by this S...
Satoshi Kurisu, Kazuhiro Nitta, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
International Journal of Cardiology   272 185-188   Dec 2018
© 2018 Background: The frontal QRS-T angle, defined as the absolute value of the difference between QRS axis and T-wave axis on 12‑lead electrocardiogram (ECG), is the difference in orientation between ventricular depolarization and repolarizatio...
高齢心不全患者と緩和ケア
木原 康樹
厚生連尾道総合病院医報   (28) 3-7   Dec 2018
ジルベール症候群患者におけるビリルビンおよび酸化ストレス、血管内皮機能の関係についての検討
丸橋 達也, 梶川 正人, 岸本 真治, 松井 翔吾, 橋本 東樹, 高永甲 有司, 日高 貴之, 野間 玄督, 木原 康樹, 東 幸仁
Anti-aging Science   10(1) 68-68   Dec 2018
エプレレノンによる特発性アルドステロン症の血管内皮機能とRho-associated kinase活性への影響
岸本 真治, 高永甲 有司, Yusoff Farina, 橋本 東樹, 松井 翔吾, 梶川 正人, 丸橋 達也, 野間 玄督, 木原 康樹, 東 幸仁
Anti-aging Science   10(1) 68-68   Dec 2018
食後血管内皮障害に対する酸化成分低減クロロゲン酸含有コーヒーの影響
梶川 正人, 丸橋 達也, 野間 玄督, 木原 康樹, 渡辺 卓也, 刀禰 寛, 日比 壮信, 大崎 紀子, 桂木 能久, 東 幸仁
Anti-aging Science   10(1) 64-64   Dec 2018
歯磨きの時間と頻度に基づく口腔衛生が心血管イベントに及ぼす影響
松井 翔吾, 梶川 正人, 高永甲 有司, 橋本 東樹, 岸本 真治, 丸橋 達也, 木原 康樹, 野間 玄督, 東 幸仁
Anti-aging Science   10(1) 61-61   Dec 2018
【心不全(第2版)上-最新の基礎・臨床研究の進歩-】 超高齢化時代を迎えた日本における心不全の動向と今後の対応
日高 貴之, 木原 康樹
日本臨床   76(増刊9 心不全(上)) 45-48   Dec 2018
Masaki Shimizu, Munechika Misumi, Michiko Yamada, Waka Ohishi, Hideya Yamamoto, Yasuki Kihara
Internal Medicine Journal   48 1331-1336   Nov 2018
© 2018 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians Background: Cognitive function and physical function are important predictors of mortality. Aim: To...
Tatsuya Maruhashi, Ichiro Hisatome, Yasuki Kihara, Yukihito Higashi
Atherosclerosis   278 226-231   Nov 2018
© 2018 The Authors Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans. In the process of purine metabolism, reactive oxygen species, including superoxide, are generated concomitantly with uric acid production...
Toshiro Kitagawa, Hideya Yamamoto, Yumiko Nakamoto, Ko Sasaki, Shinya Toshimitsu, Fuminari Tatsugami, Kazuo Awai, Yutaka Hirokawa, Yasuki Kihara
Journal of the American Heart Association   7    Oct 2018
© 2018 The Authors. Background-—Application of 18 F-sodium fluoride ( 18 F-NaF) positron emission tomography (PET) to coronary artery disease has attracted interest. We investigated the utility of 18 F-NaF uptake for predicting coronary events an...
Lin Shi, Kurumi Fujioka, Nami Sakurai-Ozato, Wataru Fukumoto, Kenichi Satoh, Jiying Sun, Akinori Awazu, Kimio Tanaka, Mari Ishida, Takafumi Ishida, Yukiko Nakano, Yasuki Kihara, C. Nelson Hayes, Hiroshi Aikata, Kazuaki Chayama, Takashi Ito, Kazuo Awai, Satoshi Tashiro
Radiation Research   190 424-432   Oct 2018
© 2018 by Radiation Research Society. The incidence of chromosomal abnormalities and cancer risk correlates well with the radiation dose after exposure to moderate-To high-dose ionizing radiation. However, the biological effects and health risks ...
抗がん剤による薬剤性心筋症治療に対する心不全センターの取り組み
櫻下 弘志, 佐伯 康之, 石井 聡一郎, 中 麻規子, 中山 奨, 木原 康樹, 松尾 裕彰
日本癌治療学会学術集会抄録集   56回 P115-6   Oct 2018
血管機能検査Up to date「血管不全の診断基準」 血管内皮機能検査Flow-mediated vasodilation(FMD)
丸橋 達也, 木原 康樹, 冨山 博史, 東 幸仁
日本臨床生理学会雑誌   48(4) 79-79   Oct 2018
左室駆出率の保たれた心不全患者における運動負荷心エコー図指標と最大酸素摂取量との関連についての検討
政田 賢治, 上田 浩徳, 日高 貴之, 宇都宮 裕人, 木原 康樹
広島医学   71(10付録) 18-18   Oct 2018
三尖弁閉鎖不全症における弁輪の拡大方向は弁輪径計測に影響をあたえる 三次元経食道心エコーを用いた検討
宇都宮 裕人, 須澤 仁, 泉 可奈子, 原田 侑, 木下 未来, 板倉 希帆, 日高 貴之, 木原 康樹, 池永 寛樹, 塩田 隆弘
広島医学   71(10) 716-716   Oct 2018
負荷による僧帽弁逆流増悪を3次元的に評価した若年難治性心不全の1症例
原田 侑, 日高 貴之, 宇都宮 裕人, 板倉 希帆, 木下 未来, 須澤 仁, 泉 可奈子, 木原 康樹
広島医学   71(10) 716-716   Oct 2018
日高 貴之, 木原 康樹
医学のあゆみ   266(13) 1159-1162   Sep 2018
木原 康樹
日本内科学会雑誌   107(9) 1858-1864   Sep 2018
Hiroto Utsunomiya, Takayuki Hidaka, Hitoshi Susawa, Kanako Izumi, Yu Harada, Mirai Kinoshita, Kiho Itakura, Kenji Masada, Yasuki Kihara
Circulation. Cardiovascular imaging   11    Sep 2018
Background Effort intolerance, measured objectively by reduced peak oxygen consumption (Vo2), has been considered as an important prognosticator in degenerative mitral regurgitation (MR). However, its mechanism is unknown. Methods and Results In 2...
Shunsuke Tomomori, Yukiko Nakano, Hidenori Ochi, Yuko Onohara, Akinori Sairaku, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Michitaka Amioka, Naoya Hironobe, Yousaku Ookubo, Shou Okamura, Hiroshi Kawazoe, Kazuaki Chayama, Yasuki Kihara
PLoS ONE   13    Sep 2018
© 2018 Tomomori et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ar...
Hideya Yamamoto, Yasuki Kihara, Toshiro Kitagawa, Norihiko Ohashi, Eiji Kunita, Yoshitaka Iwanaga, Kazuhiro Kobuke, Shunichi Miyazaki, Tomohiro Kawasaki, Shinichiro Fujimoto, Hiroyuki Daida, Takashi Fujii, Aki Sato, Tomokazu Okimoto, Sachio Kuribayashi, Hiroto Utsunomiya, Atsuhiro Senoo, Eriko Matsunaga, Kazuhisa Takamura, Ryoko Kinoshita, Yasuhiko Hayashi, Hideo Himeno, Takeshi Kondo, Shinichiro Fujimoto, Akira Yamashina, Masaharu Hirano, Kenji Ando, Kyohei Yamaji, Noriko Inoue, Keigo Dote, Masaya Kato, Shota Sasaki, Masaki Kawamura, Kiyotaka Oshima, Atsushi Hirayama, Shunichi Yoda, Hideaki Yoshino, Haruhisa Ishiguro, Osamu Doi, Shota Fukuda, Kenei Shimada, Tomoko Nao, Kengo Tanabe, Teruhito Mochizuki, Akira Kurata, Hiroshi Morishita, Naoya Matsumoto, Hiroshi Ohta
Journal of Cardiovascular Computed Tomography   12 436-443   Sep 2018
© 2018 The Authors Background: Coronary computed tomography angiography (CCTA) not only provides information regarding luminal stenoses but also allows for visualization of mural atheromatous changes (coronary plaques). Objective: We sought to elu...
侵襲的肺動脈圧測定を用いた無症候性僧帽弁閉鎖不全症患者における運動中肺動脈圧規定因子の探索
日高 貴之, 宇都宮 裕人, 木下 未来, 原田 侑, 須澤 仁, 泉 可奈子, 石橋 堅, 北川 知郎, 福田 幸弘, 栗栖 智, 山本 秀也, 木原 康樹
日本心臓病学会学術集会抄録   66回 EP-248   Sep 2018
負荷心筋血流SPECTのタリウム洗い出しにおける心房細動の影響
栗栖 智, 住元 庸二, 池永 寛樹, 石橋 堅, 福田 幸弘, 木原 康樹
日本心臓病学会学術集会抄録   66回 O-011   Sep 2018
心不全治療の地域連携 在宅心不全患者の疾病管理を支える地域医療ネットワーク
日高 貴之, 木原 康樹, 北川 知郎, 中 麻規子, 中山 奨
日本心臓病学会学術集会抄録   66回 S2-2   Sep 2018
降圧薬内服中高血圧患者の血管内皮機能は、血圧値に関わらず障害されている FMD-J研究
丸橋 達也, 梶川 正人, 岸本 真治, 松井 翔吾, 橋本 東樹, 高永甲 有司, 日高 貴之, 野間 玄督, 冨山 博史, 高瀬 凡平, 山科 章, 木原 康樹, 東 幸仁
日本高血圧学会総会プログラム・抄録集   41回 PC09-02   Sep 2018
糖代謝異常症例の予後に与える高血圧の影響
佐々木 伸夫, 小園 亮次, 前田 亮, 木原 康樹
日本高血圧学会総会プログラム・抄録集   41回 OE02-03   Sep 2018
高血圧診療で知っておくべき血管疾患 高血圧と血管機能不全
丸橋 達也, 木原 康樹, 東 幸仁
日本高血圧学会総会プログラム・抄録集   41回 SSY3-3   Sep 2018
超高齢社会における循環器診療
木原 康樹
日本内科学会雑誌   107(9) 1858-1864   Sep 2018
未治療高血圧患者の血管機能についての検討
丸橋 達也, 梶川 正人, 岸本 真治, 松井 翔吾, 橋本 東樹, 高永甲 有司, 日高 貴之, 野間 玄督, 木原 康樹, 東 幸仁
脈管学   58(Suppl.) S270-S270   Sep 2018
腹部大動脈瘤切迫破裂部位にFDGPETの集積を認めた1例
山路 貴之, 丸橋 達也, 松井 翔吾, 住元 庸二, 須澤 仁, 福田 幸弘, 安信 祐治, 田中 幸一, 東 幸仁, 木原 康樹
脈管学   58(Suppl.) S250-S250   Sep 2018
冠動脈石灰化スコアと左室拡張能の関連
新田 和宏, 栗栖 智, 中本 祐美子, 住元 庸二, 妹尾 淳弘, 池永 寛樹, 立神 史稔, 石橋 堅, 北川 知郎, 福田 幸弘, 山本 秀也, 粟井 和夫, 木原 康樹
脈管学   58(Suppl.) S243-S244   Sep 2018
【心不全のすべて-分子生物学から緩和ケアまで:beyondガイドライン】さまざまな心不全-原因別に心不全を診て考える 超高齢者の心不全 超高齢者ならではの特殊性
日高 貴之, 木原 康樹
医学のあゆみ   266(13) 1159-1162   Sep 2018
わが国はすでに超高齢社会を迎えており、年齢が90歳以上の超高齢者人口が増加し続けている。加齢とともに心不全発症が増加する現実を踏まえると、今後、超高齢心不全患者数が増加することは確実である。超高齢心不全患者の特徴を把握するための疫学調査は十分ではないが、心不全発症率増加、死因としての心疾患の増加、大動脈弁狭窄症や虚血性心疾患の関与、左室駆出率の保持された心不全(HFpEF)の増加、多様な併存疾患の存在、薬剤治療域の減少、多剤併用、認知機能低下、フレイル、サルコペニア、低栄養といった特徴を有...
【心臓リモデリングをどう治すか-拡大心・肥大心へのアプローチ-】 診る MRIをどう活かすか?
北川 知郎, 木原 康樹
Heart View   22(9) 834-840   Sep 2018
<Point>1 心臓MRI検査は"one-stop shop"といわれ、ほかの画像検査や組織学的検査の要素を含む総合的な心筋評価を可能とする。2 心臓MRI検査(主に遅延造影)は、拡大と肥大を呈する心筋症の同定と重症度・予後評価に有用である。3 T1 mappingによる新たな撮像技術が、MRIを用いた心筋評価の有用性と正確性を高める可能性がある。(著者抄録)
北川 知郎, 木原 康樹
Heart view   22(9) 834-840   Sep 2018
Y. OKUBO, A. SAIRAKU, N. MORISHIMA, H. OGI, T. MATSUMOTO, H. KINOSHITA, Y. KIHARA
Journal of Cardiac Failure   24 520-524   Aug 2018
© 2018 Background: Urinary liver-type fatty acid–binding protein (L-FABP) is a potential biomarker for acute kidney injury, and it in turn increases cardiovascular mortality. We tested whether the urinary L-FABP level predicted short- and mid-term...
TAVRカテーテルバルーン破裂の1例
住元 庸二, 福田 幸弘, 新田 和宏, 池永 寛樹, 石橋 堅, 栗栖 智, 木原 康樹
日本心血管インターベンション治療学会抄録集   27回 MP282-MP282   Aug 2018
非閉塞性冠動脈疾患患者におけるスペクトでの心筋虚血と左心室拡張期パラメータとの関係
新田 和宏, 栗栖 智, 住元 庸二, 池永 寛樹, 石橋 堅, 福田 幸弘, 木原 康樹
日本心血管インターベンション治療学会抄録集   27回 MP184-MP184   Aug 2018
慢性完全閉塞病変に対する逆行性アプローチは心筋障害を増加させる
石橋 堅, 栗栖 智, 新田 和宏, 住元 庸二, 福田 幸弘, 山本 秀也, 木原 康樹
日本心血管インターベンション治療学会抄録集   27回 MP167-MP167   Aug 2018
TAVIにおけるハイレートペーシング施行時の血圧低下阻害因子の検討
中尾 司, 宮本 聡史, 坂本 優実, 川端 唯人, 松本 和希, 福田 幸弘, 木原 康樹, 高橋 信也, 末田 泰二郎, 高橋 秀暢
日本心血管インターベンション治療学会抄録集   27回 CO059-CO059   Aug 2018
Satoshi Kurisu, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Acta Cardiologica   73 371-376   Jul 2018
© 2017, © 2017 Belgian Society of Cardiology. Background: Even intermediate QRS prolongation without bundle branch block is associated with worse clinical outcome after myocardial infarction (MI). We assessed the association of QRS duration with l...
Yukiko Nakano, Hidenori Ochi, Akinori Sairaku, Yuko Onohara, Takehito Tokuyama, Chikaaki Motoda, Hiroya Matsumura, Shunsuke Tomomori, Michitaka Amioka, Naoya Hironobe, Yousaku Ohkubo, Shou Okamura, Naomasa Makita, Yukihiko Yoshida, Kazuaki Chayama, Yasuki Kihara
Circulation. Genomic and precision medicine   11    Jul 2018
© 2018 American Heart Association, Inc. BACKGROUND: Tachycardia-induced cardiomyopathy (TIC) is a reversible cardiomyopathy induced by tachyarrhythmia, and the genetic background of the TIC is not well understood. The hyperpolarization-activated c...
Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Akimichi Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Nozomu Oda, Shinji Kishimoto, Shogo Matsui, Haruki Hashimoto, Yoshiki Aibara, Farina Mohamad Yusoff, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Chikara Goto, Hirofumi Tomiyama, Bonpei Takase, Takahide Kohro, Toru Suzuki, Tomoko Ishizu, Shinichiro Ueda, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Kentaro Watanabe, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Hisao Ikeda, Akira Yamashina, Yukihito Higashi
Journal of the American Heart Association   7    Jul 2018
© 2018 The Authors. Background—The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known. Methods and Results—We measured flow-mediated vasodilation (FMD) and brachial–ankle p...
高齢者における睡眠と血清NT-proBNP値の関係について
佐々木 伸夫, 小園 亮次, 山下 英尚, 木原 康樹
日本睡眠学会定期学術集会プログラム・抄録集   43回 239-239   Jul 2018
【心不全をめぐる医療の現在と今後の展望】 心不全の緩和ケア
日高 貴之, 木原 康樹
Progress in Medicine   38(6) 603-609   Jun 2018
呉 晟名, 今井 克彦, 福田 幸弘, 高橋 信也, 黒崎 達也, 片山 桂次郎, 森田 翔平, 宇都宮 裕人, 木原 康樹, 末田 泰二郎
広島医学   71(5) 404-408   May 2018
当院で経カテーテル的大動脈弁植込術を行った45例の初期成績について検討した。平均年齢は84.6歳、男性13例、女性32例で、全例が重症の大動脈弁狭窄症であった。その結果、術後30日以内の死亡率は0%、在院死亡率は0%で、術後在院日数は経心尖アプローチ5例では平均21日、経大動脈アプローチ38例では平均15.2日、経鎖骨下動脈アプローチ2例では平均13日であった。周術期合併症は中等度以上のARを3例、術後肺水腫を4.4%、Contained rupture、永久房室伝導障害、アクセス損傷を各...
Michitaka Amioka, Akinori Sairaku, Yukiko Nakano, Takehito Tokuyama, Hiroya Matsumura, Shunsuke Tomomori, Naoya Hironobe, Yasuki Kihara
Clinical Chemistry and Laboratory Medicine   56    May 2018
Hiroki Teragawa, Yukihiro Fukuda, Yasuki Kihara
European Journal of Preventive Cardiology   25 839-841   May 2018
高齢者血圧とNT-proBNPの関係
佐々木 伸夫, 小園 亮次, 山本 秀也, 木原 康樹
日本高血圧学会臨床高血圧フォーラムプログラム・抄録集   7回 207-207   May 2018
持続性心房細動の洞調律化による右心系形態の変化についての検討
板倉 希帆, 泉 可奈子, 須澤 仁, 原田 侑, 木下 未来, 宇都宮 裕人, 日高 貴之, 木原 康樹
超音波医学   45(Suppl.) S632-S632   Apr 2018
3次元経食道心臓超音波を用いた運動誘発性僧帽弁逆流の規定因子の検討
原田 侑, 宇都宮 裕人, 日高 貴之, 板倉 希帆, 木下 未来, 須澤 仁, 泉 可奈子, 木原 康樹
超音波医学   45(Suppl.) S615-S615   Apr 2018
器質的僧帽弁閉鎖不全症における運動耐容能低下のメカニズムに関する検討
宇都宮 裕人, 須澤 仁, 泉 可奈子, 原田 侑, 木下 未来, 板倉 希帆, 日高 貴之, 木原 康樹
超音波医学   45(Suppl.) S555-S555   Apr 2018
【高齢者の心不全の早期発見・対策・治療-健康寿命の延伸に向けて】 高齢者心不全の診断
日高 貴之, 木原 康樹
カレントテラピー   36(4) 325-329   Apr 2018
相葉 裕幸, 福田 幸弘, 須澤 仁, 住元 庸二, 松井 翔吾, 丸橋 達也, 田中 幸一, 木原 康樹
心臓   50(3) 299-304   Mar 2018
79歳女性。1年前に慢性腎臓病と胸部・腹部大動脈瘤を指摘された。2ヵ月前より疼痛を伴うチアノーゼと小潰瘍が両側足趾に出現した。CT検査にて胸部大動脈瘤の拡大を認め、胸部大動脈瘤を塞栓源とするコレステロール塞栓症が疑われ当院紹介入院となった。経食道心臓超音波検査では胸部大動脈瘤に多発する複雑プラークを認めた。胸部大動脈瘤への手術介入だけでは下肢症状の改善は困難と判断し、薬物治療の方針とした。スタチンとステロイド開始後、下肢症状は徐々に改善したが、入院14日目より腹痛が出現した。PET/CT検...
左室拡張機能障害と運動耐性との関連性(Relationship between Left Ventricular Diastolic Dysfunction and Exercise Tolerance)
木下 未来, 日高 貴之, 泉 可奈子, 須澤 仁, 原田 侑, 板倉 希帆, 政田 賢治, 宇都宮 裕人, 木原 康樹
日本循環器学会学術集会抄録集   82回 PJ064-2   Mar 2018
大動脈弁狭窄患者において単球/HDL比は血栓形成と密接に関連し、左心耳の収縮を伴う(In Aortic Stenosis Patients, Monocyte/High-density Lipoprotein Ratio is Related to Thrombogenesis and Associated with Left Atrial Appendage Contraction)
福田 幸弘, 高永甲 有司, 須澤 仁, 住元 庸二, 池永 寛樹, 宇都宮 裕人, 石橋 堅, 日高 貴之, 栗栖 智, 木原 康樹
日本循環器学会学術集会抄録集   82回 PJ051-3   Mar 2018
Histidine-rich calcium-binding proteinの遺伝子バリアントSer96Alaは発作性心房細動に対するアブレーション後再発の有用な遺伝的予測因子である(Ser96Ala Genetic Variant of Histidine-rich Calcium-binding Protein is an Useful Genetic Predictor for Recurrence after Ablation of Paroxysmal Atrial Fibrillation)
網岡 道孝, 中野 由紀子, 岡村 祥央, 大久保 陽策, 廣延 直也, 友森 俊介, 元田 親章, 徳山 丈仁, 西楽 顕典, 木原 康樹
日本循環器学会学術集会抄録集   82回 PJ016-6   Mar 2018
Semaphorin 3A遺伝子多型はブルガダ症候群の自律神経機能を修飾する(Semaphorin 3A Polymorphism Modifies Autonomic Function in Brugada Syndrome)
徳山 丈仁, 中野 由紀子, 岡村 祥央, 大久保 陽策, 廣延 直也, 網岡 道孝, 友森 俊介, 松村 誠也, 元田 親章, 西楽 顕典, 木原 康樹
日本循環器学会学術集会抄録集   82回 PJ016-5   Mar 2018
患者特異的iPSCを用いた進行性心臓伝導障害の研究(Studying Progressive Cardiac Conduction Disturbance with Patient-specific iPSCs)
元田 親章, 湯浅 慎介, 中野 由紀子, 福田 恵一, 木原 康樹
日本循環器学会学術集会抄録集   82回 PJ016-2   Mar 2018
高血圧患者では過剰飲酒によって内皮細胞機能が低下する Flow-mediated Dilation Japan(FMD-J) Study(Heavy Drinking Impairs Endothelial Function in Patients with Hypertension: Flow-mediated Dilation Japan(FMD-J) Study)
小田 望, 梶川 正人, 丸橋 達也, 岸本 真治, 松井 翔吾, 橋本 東樹, 日高 貴之, 木原 康樹, 野間 玄督, 冨山 博史, 山科 章, 東 幸仁
日本循環器学会学術集会抄録集   82回 OJ10-9   Mar 2018
広島県における心不全患者のチーム管理(Team Management of Heart Failure Patients in Hiroshima Prefecture)
木原 康樹
日本循環器学会学術集会抄録集   82回 CE5-3   Mar 2018
地域社会における心不全患者のための緩和医療(Palliative Care to Heart Failure Patients in the Local Community)
木原 康樹
日本循環器学会学術集会抄録集   82回 SS22-2   Mar 2018
超高齢社会と心不全 地域社会ベースの医療体制における心不全に対する集学的介入をいかに活発化させるか 広島県心臓いきいき推進事業の目的(How to Activate Multidisciplinary Intervention for Heart Failure in Community-based Care System? Aims of the Hiroshima Heart Health Promotion Project)
日高 貴之, 木原 康樹, 北川 知郎, 山本 秀也, 栗栖 智, 中野 由紀子, 丸橋 達也, 石橋 堅, 宇都宮 裕人
日本循環器学会学術集会抄録集   82回 SY14-4   Mar 2018
チームで心臓を治す、癒す:新しい組織の構築と実践 施設内チームアプローチによる心不全の可能性のある患者に対する予防ケア 心不全センターの挑戦(Preventive Care for Patients with Possible Heart Failure by Institutional Team Approach: Challenges of Heart Failure Center)
北川 知郎, 日高 貴之, 中 麻規子, 中山 奨, 木原 康樹
日本循環器学会学術集会抄録集   82回 SY04-3   Mar 2018
【尿酸、XORと内皮細胞障害】 尿酸の血管内皮細胞障害の発症機序
丸橋 達也, 木原 康樹, 東 幸仁
高尿酸血症と痛風   26(1) 38-41   Mar 2018
動脈硬化は、血管内皮機能障害を第一段階として発症、進展し、最終的に心血管疾患発症に至る。高尿酸血症により、血管内皮機能障害が惹起される機序がいくつか推定されている。1つは、キサンチン酸化酵素が、ヒポキサンチンおよびキサンチンから尿酸を酸化する際に生じる活性酸素による障害である。もう1つは、尿酸トランスポーターを介して血管内皮細胞に取り込まれた尿酸自体による障害である。高尿酸血症に対する治療介入は、血管内皮機能を改善し、心血管疾患発症を抑制する可能性がある。(著者抄録)
【たこつぼ症候群】 たこつぼ症候群のリスク評価
栗栖 智, 木原 康樹
循環器内科   83(3) 253-256   Mar 2018
栗栖 智, 木原 康樹
循環器内科 = Cardioangiology   83(3) 253-256   Mar 2018
広島大学循環器内科同門会共同研究・ヒロシマノクターン中間報告
丸橋 達也, 木原 康樹, 木下 禎彦, 東 幸仁
広島医学   71(2) 161-162   Feb 2018
虚血性心不全への多面的治療介入が奏効した家族性高コレステロール血症の1例
渡邊 信寛, 栗栖 智, 石橋 堅, 福田 幸弘, 山本 秀也, 木原 康樹
広島医学   71(2) 123-123   Feb 2018
超高齢社会における循環器診療
木原 康樹
日本内科学会雑誌   107(Suppl.) 127-127   Feb 2018
Kazuhiro Nitta, Satoshi Kurisu, Yoji Sumimoto, Hiroki Ikenaga, Ken Ishibashi, Yukihiro Fukuda, Yasuki Kihara
Acta Cardiologica      Jan 2018
© 2019, © 2019 Belgian Society of Cardiology. Background: Left ventricular (LV) diastolic dysfunction represents an earlier step of the ischaemic cascade. We tested the hypothesis that the index of LV diastolic function from electrocardiogram (ECG...
Shinji Kishimoto, Takeshi Matsumoto, Kenji Oki, Tatsuya Maruhashi, Masato Kajikawa, Shogo Matsui, Haruki Hashimoto, Yasuki Kihara, Farina Mohamad Yusoff, Yukihito Higashi
Hypertension Research      Jan 2018
© 2018, The Japanese Society of Hypertension. The aims were to evaluate the relationship between idiopathic hyperaldosteronism (IHA) and grade of vascular function in the macrovasculature and microvasculature. Vascular function, including reactive...
Tatsuya Maruhashi, Yasuki Kihara, Yukihito Higashi
Circulation Journal   82 2377   Jan 2018
Tatsuya Maruhashi, Yasuki Kihara, Yukihito Higashi
Diabetes and Aging-related Complications   45-58   Dec 2017
© Springer Nature Singapore Pte Ltd. 2018. All rights reserved. In patients with diabetes mellitus, endothelial dysfunction is the initial step in the process of atherosclerosis and plays an important role in the development of this condition, lea...

Conference Activities & Talks

 
Heart Failure in Elderly; Acomplex of Unsolved Issues in Japan
KIHARA YASUKI
31 Mar 2019   
Thoracic Spine Hyperostosis is Associated with Atrial Fibrillation of Non-Pulmonary Vein Foci
Miyauchi S, Nakano Y, Okamura S, Okubo Y, Hironobe N, Amioka M, Motoda C, Tokuyama T, Kihara Y
31 Mar 2019   
Atrial Functional Tricuspid Regurgitation Due to Persistent Atrial Fibrillation - Echocardiographic Assessment at around Catheter Ablation Treatment -
Itakura K, Izumi K, Susawa H, Harada Y, Kinoshita M, Utsunomiya H, Hidaka T, Kihara Y
31 Mar 2019   
Plasma MicroRNAs as Non-Invasive Biomarkers in Patients with Brugada Syndrome
Nakano Y, Motoda C, Onohara Y, Tokuyama T, Amioka M, Hironobe N, Okubo Y, Okamura S, Miyauchi S, Ikeuchi Y, Nishiyama Y, Tahara H, Kihara Y
30 Mar 2019   
Association of Oral Health Based on Tooth Brushing Behavior with Cardiovascular Outcome: Two-year Follow-up Prospective Observational Study
Matsui S, Higashi Y, Takaeko Y, Hashimoto H, Kishimoto S, Kajikawa M, Maruhashi T, Hidaka T, Noma K, Kihara Y
30 Mar 2019   

Research Grants & Projects

 
Japan Agency for Medical Research and Development: Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus
Project Year: Apr 2018 - Mar 2019    Investigator(s): KIHARA YASUKI
Hospital, National Center for Geriatrics and Gerontology: Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus
Project Year: Apr 2017 - Mar 2018    Investigator(s): KIHARA YASUKI
Japan Agency for Medical Research and Development: Practical Research Project for Life-Style related Diseases including Cardiovascular Diseases and Diabetes Mellitus
Project Year: Apr 2016 - Mar 2017    Investigator(s): KIHARA YASUKI
MEXT: KAKENHI
Project Year: 2015 - 2017    Investigator(s): KIHARA YASUKI