論文

査読有り
2021年2月18日

Fish oil suppresses obesity more potently in lean mice than in diet-induced obese mice but ameliorates steatosis in such obese mice

Bioscience, Biotechnology, and Biochemistry
  • Sachiko Okue
  • ,
  • Eimi Ishikawa
  • ,
  • Ren Nakahara
  • ,
  • Tsubasa Ito
  • ,
  • Takumi Okura
  • ,
  • Mana Sakae
  • ,
  • Atsushi Miura
  • ,
  • Yori Ozaki-Masuzawa
  • ,
  • Takashi Hosono
  • ,
  • Taiichiro Seki

85
2
開始ページ
421
終了ページ
429
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/bbb/zbaa038
出版者・発行元
Oxford University Press (OUP)

ABSTRACT

This study sought to clarify the antiobesity effects of fish oil (FO) in terms of prevention and amelioration. An isocaloric diet composed of lard or FO was given to lean C57BL/6J mice for the study of prevention and high-fat diet-induced obese (DIO) mice for the study of amelioration for 4 weeks. Body weight gain and food efficiency were potently suppressed by FO in lean mice compared to lard diet-fed mice. Uncoupling protein-1 (UCP-1) expression in inguinal white adipose tissue (WAT) was also significantly induced by FO in lean mice. FO also suppressed body weight gain and food efficiency in DIO mice but did not reduce body weight. FO ameliorated liver steatosis in DIO mice by mildly inducing UCP-1 in inguinal WAT. FO suppressed obesity more potently in lean mice than in DIO mice but ameliorated steatosis in the DIO mice.

リンク情報
DOI
https://doi.org/10.1093/bbb/zbaa038
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33604637
URL
http://academic.oup.com/bbb/article-pdf/85/2/421/36667019/zbaa038.pdf
ID情報
  • DOI : 10.1093/bbb/zbaa038
  • eISSN : 1347-6947
  • PubMed ID : 33604637

エクスポート
BibTeX RIS