論文

査読有り 筆頭著者
2015年4月

Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice

Journal of Nutritional Science and Vitaminology
  • Akiko NAKAMOTO
  • ,
  • Emi SHUTO
  • ,
  • Rie TSUTSUMI
  • ,
  • Mariko NAKAMOTO
  • ,
  • Yoshitaka NII
  • ,
  • Tohru SAKAI

61
2
開始ページ
147
終了ページ
153
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3177/jnsv.61.147
出版者・発行元
Center for Academic Publications Japan

Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.

リンク情報
DOI
https://doi.org/10.3177/jnsv.61.147
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26052145
ID情報
  • DOI : 10.3177/jnsv.61.147
  • ISSN : 0301-4800
  • eISSN : 1881-7742
  • PubMed ID : 26052145

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