Apr, 2015
Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice
Journal of Nutritional Science and Vitaminology
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- Volume
- 61
- Number
- 2
- First page
- 147
- Last page
- 153
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.3177/jnsv.61.147
- Publisher
- Center for Academic Publications Japan
Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c(+) cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3(+) cells from naïve CD4(+) cell by CD11c(+) cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.
- Link information
- ID information
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- DOI : 10.3177/jnsv.61.147
- ISSN : 0301-4800
- eISSN : 1881-7742
- Pubmed ID : 26052145