論文

査読有り
2015年2月

Dietary Ribonucleic Acid Suppresses Inflammation of Adipose Tissue and Improves Glucose Intolerance That Is Mediated by Immune Cells in C57BL/6 Mice Fed a High-Fat Diet

Journal of Nutritional Science and Vitaminology
  • Tohru SAKAI
  • ,
  • Tomoyo TAKI
  • ,
  • Akiko NAKAMOTO
  • ,
  • Shiho TAZAKI
  • ,
  • Mai ARAKAWA
  • ,
  • Mariko NAKAMOTO
  • ,
  • Rie TSUTSUMI
  • ,
  • Emi SHUTO

61
1
開始ページ
73
終了ページ
78
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3177/jnsv.61.73
出版者・発行元
Center for Academic Publications Japan

Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner.

リンク情報
DOI
https://doi.org/10.3177/jnsv.61.73
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25994141
ID情報
  • DOI : 10.3177/jnsv.61.73
  • ISSN : 0301-4800
  • eISSN : 1881-7742
  • PubMed ID : 25994141

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