論文

査読有り 筆頭著者
2019年6月30日

Nobiletin Enhances Induction of Antigen-Specific Immune Responses in BALB/c Mice Immunized with Ovalbumin

Journal of Nutritional Science and Vitaminology
  • Akiko NAKAMOTO
  • ,
  • Mami MITANI
  • ,
  • Kana URAYAMA
  • ,
  • Akari MAKI
  • ,
  • Mariko NAKAMOTO
  • ,
  • Emi SHUTO
  • ,
  • Yoshitaka NII
  • ,
  • Tohru SAKAI

65
3
開始ページ
278
終了ページ
282
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3177/jnsv.65.278
出版者・発行元
Center for Academic Publications Japan

We examined the effect of nobiletin (5,6,7,8,3',4'-hexamethoxyflavone) on immune response in ovalbumin (OVA)-immunized mice. Treatment with nobiletin increased OVA-specific IL-4 and IL-10 production. In addition, mice that received nobiletin showed higher levels of OVA-specific IgE, IgG and IgG1 production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl-Ficoll was not different in the control and nobiletin groups, suggesting that nobiletin does not directly stimulate antibody production. An in vitro study showed that treatment with nobiletin enhanced the ability of antigen presentation of bone marrow-derived dendritic cells. The in vivo and in vitro results indicate that nobiletin regulates immune function.

リンク情報
DOI
https://doi.org/10.3177/jnsv.65.278
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31257269
URL
https://www.jstage.jst.go.jp/article/jnsv/65/3/65_278/_pdf
ID情報
  • DOI : 10.3177/jnsv.65.278
  • ISSN : 0301-4800
  • eISSN : 1881-7742
  • PubMed ID : 31257269

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