論文

査読有り
2019年

Sudachitin, polymethoxyflavone from Citrus sudachi, enhances antigen-specific cellular and humoral immune responses in BALB/c mice

Journal of Clinical Biochemistry and Nutrition
  • Mami Mitani
  • ,
  • Yuki Minatogawa
  • ,
  • Akiko Nakamoto
  • ,
  • Mariko Nakamoto
  • ,
  • Emi Shuto
  • ,
  • Yoshitaka Nii
  • ,
  • Tohru Sakai

64
2
開始ページ
158
終了ページ
163
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3164/jcbn.18-70
出版者・発行元
The Society for Free Radical Research Japan

Scdachitin is a polymethoxyflavone (5,7,4'-trihydroxy-6,8,3-trimethoxyflavone) that is found in the peel of Citrus sudachi. We examined the effect of sudachitin on immune response in ovalbumin-immunized BALB/c mice. Treatment with sudachitin increased ovalbumin-specific IL-4 and IL-10 productions. In addition, mice that received sudachitin showed higher levels of ovalbumin-specific IgE, IgG1 and IgG l production than did control mice. The antibody response to the thymus-independent antigen 2,4,6-trinitrophenyl Ficoll was not different in the control and sudachitin groups, suggesting that sudachitin does not directly stimulate antibody production. An in vitro study showed that treatment of sudachitin enhanced the ability of antigen presentation in bone marrow-derived dendritic cells. Furthermore, CD11c+ cells that had been treated with sudachitin showed increased expression of co-stimulatory molecules. The results indicate that sudachitin regulates immune function both in vivo and in vitro.

リンク情報
DOI
https://doi.org/10.3164/jcbn.18-70
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30936628
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436041
URL
https://www.jstage.jst.go.jp/article/jcbn/64/2/64_18-70/_pdf
ID情報
  • DOI : 10.3164/jcbn.18-70
  • ISSN : 0912-0009
  • eISSN : 1880-5086
  • PubMed ID : 30936628
  • PubMed Central 記事ID : PMC6436041

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