論文

国際誌
2016年12月16日

CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.

Scientific reports
  • Yoshimi Nakagawa
  • ,
  • Aoi Satoh
  • ,
  • Hitomi Tezuka
  • ,
  • Song-Iee Han
  • ,
  • Kenta Takei
  • ,
  • Hitoshi Iwasaki
  • ,
  • Shigeru Yatoh
  • ,
  • Naoya Yahagi
  • ,
  • Hiroaki Suzuki
  • ,
  • Yasumasa Iwasaki
  • ,
  • Hirohito Sone
  • ,
  • Takashi Matsuzaka
  • ,
  • Nobuhiro Yamada
  • ,
  • Hitoshi Shimano

6
開始ページ
39182
終了ページ
39182
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep39182

CREB3L3 is involved in fatty acid oxidation and ketogenesis in a mutual manner with PPARα. To evaluate relative contribution, a combination of knockout and transgenic mice was investigated. On a ketogenic-diet (KD) that highlights capability of hepatic ketogenesis, Creb3l3-/- mice exhibited reduction of expression of genes for fatty oxidation and ketogenesis comparable to Ppara-/- mice. Most of the genes were further suppressed in double knockout mice indicating independent contribution of hepatic CREB3L3. During fasting, dependency of ketogenesis on CREB3L3 is lesser extents than Ppara-/- mice suggesting importance of adipose PPARα for supply of FFA and hyperlipidemia in Creb3l3-/- mice. In conclusion CREB3L3 plays a crucial role in hepatic adaptation to energy starvation via two pathways: direct related gene regulation and an auto-loop activation of PPARα. Furthermore, as KD-fed Creb3l3-/- mice exhibited severe fatty liver, activating inflammation, CREB3L3 could be a therapeutic target for NAFLD.

リンク情報
DOI
https://doi.org/10.1038/srep39182
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27982131
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159891
ID情報
  • DOI : 10.1038/srep39182
  • PubMed ID : 27982131
  • PubMed Central 記事ID : PMC5159891

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