2016年5月1日
Maniwamycins: New quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025
Journal of Antibiotics
- ,
- ,
- ,
- 巻
- 69
- 号
- 5
- 開始ページ
- 395
- 終了ページ
- 399
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/ja.2015.126
- 出版者・発行元
- Nature Publishing Group
Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C-F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The structures of maniwamycins were elucidated by spectroscopic analyses, including NMR. The compounds each have an azoxy moiety. All maniwamycins inhibited violacein synthesis, which is controlled by quorum sensing, in Chromobacterium violaceum CV026.
- ID情報
-
- DOI : 10.1038/ja.2015.126
- ISSN : 1881-1469
- ISSN : 0021-8820
- PubMed ID : 26648117
- SCOPUS ID : 84971298412