論文

査読有り
2012年12月

Identification of L-3-hydroxykynurenine O-sulfate in the buccal gland secretion of the parasitic lamprey, Lethenteron japonicum

AMINO ACIDS
  • Shoji Odani
  • ,
  • Naoko Ito
  • ,
  • Mai Hasegawa
  • ,
  • Toshio Uchiumi
  • ,
  • Sumihiro Hase

43
6
開始ページ
2505
終了ページ
2512
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00726-012-1331-x
出版者・発行元
SPRINGER WIEN

Parasitic lampreys are known to secrete proteins having anticoagulant and vasodilator activities from the buccal glands during feeding on their host's blood. However, small molecules in the secretion have never been explored in detail. We examined the secretion of Japanese liver lamprey (Lethenteron japonicum) for small molecules and found an intensely fluorescent substance upon gel filtration. After purification by anion-exchange chromatography and reversed-phase HPLC, structure of the compound was determined to be l-3-hydroxykynurenine O-sulfate by NMR- and UV-spectrometry, complemented with enzymatic and chemical degradation. In vertebrates, the sulfate ester of 3-hydroxykynurenine is a compound that has been regarded as a urinary metabolite of tryptophan but not reported from normal tissues to date. Although the function of this molecule in the buccal glands remains to be elucidated, it is remarkable that the same substance was described in 1960s from two species of blood-sucking insects, Rhodnius prolixus and Triatoma infestans, suggesting its potential role in blood-feeding.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1007/s00726-012-1331-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22648634
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000310885500024&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s00726-012-1331-x
  • ISSN : 0939-4451
  • PubMed ID : 22648634
  • Web of Science ID : WOS:000310885500024

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