論文

査読有り
2017年9月

Oxytocin effects on emotional response to others' faces via serotonin system in autism: A pilot study

PSYCHIATRY RESEARCH-NEUROIMAGING
  • Mina Fukai
  • ,
  • Tetsu Hirosawa
  • ,
  • Mitsuru Kikuchi
  • ,
  • Yasuomi Ouchi
  • ,
  • Tetsuya Takahashi
  • ,
  • Yuko Yoshimura
  • ,
  • Yoshiaki Miyagishi
  • ,
  • Hirotaka Kosaka
  • ,
  • Masamichi Yokokura
  • ,
  • Etsuji Yoshikawa
  • ,
  • Tomoyasu Bunai
  • ,
  • Yoshio Minabe

267
開始ページ
45
終了ページ
50
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.pscychresns.2017.06.015
出版者・発行元
ELSEVIER IRELAND LTD

The oxytocin (OT)-related serotonergic system is thought to play an important role in the etiology and social symptoms of autism spectrum disorder (ASD). However, no evidence exists for the relation between the prosocial effect of chronic OT administration and the brain serotonergic system. Ten male subjects with ASD were administered OT for 8-10 weeks in an open-label, single-arm, non-randomized, uncontrolled manner. Before and during the OT treatment, positron emission tomography was used with the (C-11)-amino4(2-[(demethylamino)methyl]phenylthio)benzonitrile(C-11-DASB) radiotracer. Then binding of serotonin transporter (11C-DASB BPND) was estimated. The main outcome measures were changes in C-11-DASB BPND and changes in the emotional response to others' faces. No significant change was found in the emotional response to others' faces after the 8-10 week OT treatment. However, the increased serotonin transporter (SERT) level in the striatum after treatment was correlated significantly with increased negative emotional response to human faces. This study revealed a relation between changes in the serotonergic system and in prosociality after chronic OT administration. Additional studies must be conducted to verify the chronic OT effects on social behavior via the serotonergic system.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.pscychresns.2017.06.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28738293
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000409152900007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.pscychresns.2017.06.015
  • ISSN : 0925-4927
  • eISSN : 1872-7506
  • PubMed ID : 28738293
  • Web of Science ID : WOS:000409152900007

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