論文

査読有り
2017年2月

The acute social defeat stress and nest-building test paradigm: A potential new method to screen drugs for depressive-like symptoms

BEHAVIOURAL PROCESSES
  • Hikari Otabi
  • ,
  • Tatsuhiko Goto
  • ,
  • Tsuyoshi Okayama
  • ,
  • Daisuke Kohari
  • ,
  • Atsushi Toyoda

135
開始ページ
71
終了ページ
75
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.beproc.2016.12.003
出版者・発行元
ELSEVIER SCIENCE BV

Psychosocial stress can cause mental conditions such as depression in humans. To develop drug therapies for the treatment of depression, it is necessary to use animal models of depression to screen drug candidates that exhibit anti-depressive effects. Unfortunately, the present methods of drug screening for antidepressants, the forced-swim test and tail-suspension test, are limiting factors in drug discovery because they are not based on the constructive validity of objective phenotypes in depression. Previously, we discovered that the onset of nest building is severely delayed in mice exposed to subchronic mild social defeat stress (sCSDS). Therefore, a novel paradigm combining acute social defeat stress (ASDS) and the nest-building test (SNB) were established for the efficient screening of drugs for depressive-like symptoms. Since ASDS severely delayed the nest-building process as shown in chronically social defeated mice, we sought to rescue the delayed nest-building behavior in ASDS mice. Injecting a specific serotonin 2a receptor antagonist (SR-46349B), the nest-building deficit exhibited by ASDS mice was partially rescued. On the other hand, a selective serotonin reuptake inhibitor (fluoxetine) did not rescue the nest building deficit in ASDS mice. Therefore, we conclude that the SNB paradigm is an another potential behavioral method for screening drugs for depressive-like symptoms including attention deficit, anxiety, low locomotion, and decreased motivation. (C) 2016 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 13

リンク情報
DOI
https://doi.org/10.1016/j.beproc.2016.12.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27939810
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000394403200012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.beproc.2016.12.003
  • ISSN : 0376-6357
  • eISSN : 1872-8308
  • PubMed ID : 27939810
  • Web of Science ID : WOS:000394403200012

エクスポート
BibTeX RIS