論文

査読有り
2016年1月

Subchronic and mild social defeat stress alter mouse nest building behavior

BEHAVIOURAL PROCESSES
  • Hikari Otabi
  • ,
  • Tatsuhiko Goto
  • ,
  • Tsuyoshi Okayama
  • ,
  • Daisuke Kohari
  • ,
  • Atsushi Toyoda

122
開始ページ
21
終了ページ
25
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.beproc.2015.10.018
出版者・発行元
ELSEVIER SCIENCE BV

Behavioral and physiological evaluations of animal models of depression are essential to thoroughly understand the mechanisms of depression in humans. Various models have been developed and characterized, and the socially defeated mouse has been widely used for studying depression. Here, we developed and characterized a mouse model of social aversion using a subchronic and mild social defeat stress (sCSDS) paradigm. Compared to control mice, sCSDS mice showed significantly increased body weight gain, water intake, and social aversion to dominant mice on the social interaction test. We observed nest building behavior in sCSDS mice using the pressed cotton as a nest material. Although sCSDS mice eventually successfully built nests, the onset of nest building was severely delayed compared to control mice. The underlying mechanism of this significant delay in nest building by sCSDS mice is unclear. However, our results demonstrate that nest building evaluation is a simple and useful assay for understanding behavior in socially defeated mice and screening drugs such as antidepressants. (c) 2015 Elsevier B.V. All rights reserved.

Web of Science ® 被引用回数 : 23

リンク情報
DOI
https://doi.org/10.1016/j.beproc.2015.10.018
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26524409
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368964300004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.beproc.2015.10.018
  • ISSN : 0376-6357
  • eISSN : 1872-8308
  • PubMed ID : 26524409
  • Web of Science ID : WOS:000368964300004

エクスポート
BibTeX RIS