論文

査読有り
2015年10月

Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients

BMC GASTROENTEROLOGY
  • Kosuke Sakitani
  • Yoshihiro Hirata
  • Nobumi Suzuki
  • Satoki Shichijo
  • Ayako Yanai
  • Takako Serizawa
  • Kei Sakamoto
  • Masao Akanuma
  • Shin Maeda
  • Yutaka Yamaji
  • Yasuhiko Iwamoto
  • Shoji Kawazu
  • Kazuhiko Koike
  • 全て表示

15
開始ページ
143
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s12876-015-0377-0
出版者・発行元
BIOMED CENTRAL LTD

Background: Helicobacter pylori infection is the most important risk factor for gastric cancer, for which eradication therapy is commonly performed. However, gastric cancer is sometimes discovered after successful eradication of H. pylori. Much evidence indicates that diabetes mellitus (DM) is a risk factor for gastric cancer. The incidence and characteristics of gastric cancer diagnosed after H. pylori eradication in DM patients remain to be determined.
Methods: We followed the clinical course of patients who underwent H. pylori eradication therapy at our institution. Endoscopy was performed before and after eradication. We compared the incidence and clinical characteristics of gastric cancer arising in DM and non-DM patients.
Results: In total, 965 patients who underwent successful eradication (518 DM and 447 non-DM patients) were followed-up for an average of 4.5 years. During the follow-up period, 21 gastric cancers were diagnosed (12 in DM patients and 9 in non-DM patients). The incidence of gastric cancer after eradication was not significantly different between DM and non-DM patients (0.485 and 0.482 %/year, respectively). There was no significant difference in the pathology, diameter, depth, location, or treatment of gastric cancer between patients with and without DM.
Conclusion: The incidence and characteristics of gastric cancer occurring after H. pylori eradication were comparable between DM and non-DM patients.

リンク情報
DOI
https://doi.org/10.1186/s12876-015-0377-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26486595
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364364800001&DestApp=WOS_CPL
ID情報
  • DOI : 10.1186/s12876-015-0377-0
  • ISSN : 1471-230X
  • PubMed ID : 26486595
  • Web of Science ID : WOS:000364364800001

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