2017年9月
Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells
Bioscience, Biotechnology and Biochemistry
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- 巻
- 81
- 号
- 11
- 開始ページ
- 2212
- 終了ページ
- 2215
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1080/09168451.2017.1374830
- 出版者・発行元
- Japan Society for Bioscience Biotechnology and Agrochemistry
The regulating role of phosphatidylinositide 3-ki-nase (PI3K) in benzyl isothiocyanate (BITC)-induced Nrf2 activation, contributing to the inducible expression of cytoprotective genes, was investigated. BITC significantly enhanced the accumulation of Nrf2 as well as autophagic molecules in human colorectal cancer HCT-116 cells. Experiments using a PI3K-specific inhibitor suggested that PI3K plays the key role in the non-canonical Nrf2 activation by BITC.
- リンク情報
- ID情報
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- DOI : 10.1080/09168451.2017.1374830
- ISSN : 1347-6947
- ISSN : 0916-8451
- PubMed ID : 28934922
- SCOPUS ID : 85034415737