2011年
Calothrixins AとBの全合成
反応と合成の進歩シンポジウム 発表要旨概要
- ,
- ,
- 巻
- 37
- 号
- 0
- 開始ページ
- 18
- 終了ページ
- 18
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.14895/hannou.37.0.18.0
- 出版者・発行元
- 日本薬学会化学系薬学部会
We have demonstrated a new approach to synthesizing calothrixins A and B through the palladium-catalyzed tandem cyclization/cross-coupling reaction of indolylborate by taking advantage of the one-pot generation of the hexatrienes as a key intermediate for constructing indolophenanthridine. In addition, the unprecedented use of CuOTf for 6π-electrocyclization of hexatriene was developed. In another key transformation, indolophenanthridine quinone core of calothrixins was prepared from the indolophenanthridine aldehyde via one-pot Dakin oxidation sequence catalyzed by diphenyldiselenide.
- リンク情報
- ID情報
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- DOI : 10.14895/hannou.37.0.18.0
- CiNii Articles ID : 130006995751