MISC

2011年

Calothrixins AとBの全合成

反応と合成の進歩シンポジウム 発表要旨概要
  • 阿部 匠
  • ,
  • 池田 敏明
  • ,
  • 石倉 稔

37
0
開始ページ
18
終了ページ
18
記述言語
日本語
掲載種別
DOI
10.14895/hannou.37.0.18.0
出版者・発行元
日本薬学会化学系薬学部会

We have demonstrated a new approach to synthesizing calothrixins A and B through the palladium-catalyzed tandem cyclization/cross-coupling reaction of indolylborate by taking advantage of the one-pot generation of the hexatrienes as a key intermediate for constructing indolophenanthridine. In addition, the unprecedented use of CuOTf for 6π-electrocyclization of hexatriene was developed. In another key transformation, indolophenanthridine quinone core of calothrixins was prepared from the indolophenanthridine aldehyde via one-pot Dakin oxidation sequence catalyzed by diphenyldiselenide.

リンク情報
DOI
https://doi.org/10.14895/hannou.37.0.18.0
CiNii Articles
http://ci.nii.ac.jp/naid/130006995751
ID情報
  • DOI : 10.14895/hannou.37.0.18.0
  • CiNii Articles ID : 130006995751

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