2013年
多官能性合成素子を用いるインドール化合物の合成
薬学雑誌
- 巻
- 133
- 号
- 1
- 開始ページ
- 99
- 終了ページ
- 106
- 記述言語
- 日本語
- 掲載種別
- DOI
- 10.1248/yakushi.12-00233
- 出版者・発行元
- 日本薬学会
This review describes a synthesis of indole compounds using multifunctional synthons. The multifunctional synthons, trienes and gramines, were respectively synthesized using Pd-catalyzed tandem cyclization/cross-coupling reaction of indolylborate with vinyl bromide, and reaction of indolylcuprate with iminium chloride. As an application of the multifunctional synthons to the indole alkaloids synthesis, we accomplished the total synthesis of ellipticine, 9-methoxyellipticine, 9-hydroxyellipticine, tetrahydroellipticine, μ-alkaloid B, μ-alkaloid D, calothrixin A, calothrixin B, tubifoline, and yuehchukene. We have also developed 6π-electrocyclization of hexatrienes catalyzed by Cu(I) trifluoromethanesulfonate toluene complexe, which is unprecedented.
- リンク情報
- ID情報
-
- DOI : 10.1248/yakushi.12-00233
- ISSN : 1347-5231
- ISSN : 0031-6903
- CiNii Articles ID : 40019555794
- identifiers.cinii_nr_id : 9000024956012
- SCOPUS ID : 84946185177