2017年11月
An Ullmann N-arylation/2-amidation cascade by self-relay copper catalysis: one-pot synthesis of indolo[1,2-a]quinazolinones
ORGANIC CHEMISTRY FRONTIERS
- ,
- ,
- ,
- 巻
- 4
- 号
- 11
- 開始ページ
- 2124
- 終了ページ
- 2127
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c7qo00549k
- 出版者・発行元
- ROYAL SOC CHEMISTRY
We have developed a self-relay copper(I)-catalyzed Ullmann N-arylation/2-amidation cascade to form functionalized indolo[1,2-a]quinazolinones in one-pot from easily available indoles with 2-bromobenzamides. This novel transformation features a tandem process of Ullmann-type coupling, activation of indolenine, and 2-amidation in the presence of a single copper catalyst. In addition, among the substituents of indoles at the C3 position, methyl carboxylate could act as an activating group in this Ullmann N-arylation/2-amidation cascade.
- リンク情報
- ID情報
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- DOI : 10.1039/c7qo00549k
- ISSN : 2052-4129
- ORCIDのPut Code : 35631860
- Web of Science ID : WOS:000413826400007